Comparison of the Amino Acid Tracers¹⁸F-FET and¹⁸F-DOPA in High-Grade Glioma Patients

Brain PET imaging optimization with time of flight and point spread function modelling

“…Although Nagaki et al [10] have previously studied the influence of the advanced reconstruction techniques for brain PET, this is the first study to perform a systematic optimization of reconstruction parameters for each algorithm. In fact, a standard reconstruction for brain PET in last generation PET tomographs has not been established yet and recent brain studies performed with modern scanners reconstruct images with classical OSEM algorithm and do not take advantage of the available advanced reconstruction protocols [11][12][13].…”

“…Nevertheless, few investigations have focused in the field of brain PET [10] and a standard reconstruction protocol has not been established yet. In fact, recent brain studies performed with last generation PET scanners are using classical OSEM algorithm and do not take advantage of the advanced reconstruction techniques maybe due to the lack of an optimization study [11][12][13]. Within this framework, the aim of this study is to investigate the influence of reconstruction parameters on PET image quality using brain phantoms as well as to select the best reconstruction algorithm and the optimal reconstruction parameters for clinical PET brain studies with different tracers.…”

Improved synthesis of [18F]FS-PTAD as a new tyrosine-specific prosthetic group for radiofluorination of biomolecules

“…3, the coupling step was carried out using N-acetyl-L-tyrosine methyl amide and phenol as model compounds and rapidly conjugated with [ 18 F]FS-PTAD ([ 18 F]4) under mild aqueous condition (phosphate buffer, pH 7) in acetonitrile at room temperature for 5 min, resulting to the radiofluorinated compounds [ 18 F]6a and [ 18 F]b in 587 4.2% and 45 75.6% radiochemical yield, respectively. The (Lapa et al, 2014;Wester et al, 1999;Kinoshita et al, 2012). Since our focus is based on the coupling of the radiofluorinated prosthetic group with peptides and antibodies.…”

PET for Therapy Response Assessment in Glioblastoma

“…Several studies have also indicated that time-activity curves of 18 F-FET uptake contain biological information beyond that of static images, and these data may be helpful for glioma grading (31). In HGGs, uptake patterns of 18 F-FDOPA are not significantly different from 18 F-FET, but both SUV mean and LNRs were 10-15% higher for 18 F-FET than 18 F-FDOPA (69).…”