Brain PET imaging optimization with time of flight and point spread function modelling

Prieto, Elena; Martí-Climent, Josep M.; Morán, Verónica; Sancho, Lidia; Barbés, Benigno; Arbizu, Javier; Richter, José A.

doi:10.1016/j.ejmp.2015.07.001

Cited by 16 publications

(18 citation statements)

References 24 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other radiotracers have been synthetized for glioma assessment (other amino-acid radiotracers like 11 Firstly, regarding static parameters, our results showed that tumor SUVmax and SUVmean obtained with PSF reconstruction were significantly higher than without PSF reconstruction. These results are consistent with data from previous studies assessing the impact of PSF on these parameters (11)(12)(13)(14). Regarding the SUVmean, the results of the current study showed smaller deviations compared to the SUVmax.…”

Section: Discussionsupporting

confidence: 93%

“…In our study, the mean percentage change after PSF implementation is considerably lower than in most reports assessing the impact of PSF (12,14,(26)(27)(28). This could be linked to the fact that the current study compared images reconstructed with and without PSF but with TOF algorithm, which already provides higher SUV than SUV obtained with reconstruction using non-TOF algorithm (9,13). The PET images showed essentially low tumors FDOPA uptake in our study.…”

Section: Discussioncontrasting

confidence: 68%

“…Conventional iterative reconstruction methods lead to distortion at the edges of the field-of-view and PET images are subject to partial volume effect and spillover of signal between adjacent functional regions (9). The point-spread function (PSF) reconstruction technique recently available for PET imaging improved the image contrast to noise ratios and the spatial resolution, correcting for the photon mispositioning and increasing radial offset from the isocenter in PET systems (10)(11)(12)(13). Studies using several PET tracers suggested that the implementation of PSF reconstruction increases static parameters values compared with non-PSF data (14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of point-spread function reconstruction on dynamic and static 18F-DOPA PET/CT quantitative parameters in glioma

Girard¹,

François²,

Chaboub³

et al. 2022

Quant Imaging Med Surg

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of point-spread function reconstruction on dynamic and static 18F-DOPA PET/CT quantitative parameters in glioma

Girard¹,

François²,

Chaboub³

et al. 2022

Quant Imaging Med Surg

View full text Add to dashboard Cite

“…5. Dynamic or list-mode acquisition [115,116] To date, the benefit of time-of-flight correction has been modest, but it can be applied [117,118]. 4.…”

Section: Head Stabilitymentioning

confidence: 99%

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Morbelli

Esposito

Arbizu

et al. 2020

Eur J Nucl Med Mol Imaging

Self Cite

156

174

View full text Add to dashboard Cite

Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The goal of this guideline is to assist nuclear medicine practitioners in recommending, performing, interpreting, and reporting the results of dopaminergic imaging in parkinsonian syndromes. Methods Currently nuclear medicine investigations can assess both presynaptic and postsynaptic function of dopaminergic synapses. To date both EANM and SNMMI have published procedural guidelines for dopamine transporter imaging with single photon emission computed tomography (SPECT) (in 2009 and 2011, respectively). An EANM guideline for D2 SPECT imaging is also available (2009). Since the publication of these previous guidelines, new lines of evidence have been made available on semiquantification, harmonization, comparison with normal datasets, and longitudinal analyses of dopamine transporter imaging with SPECT. Similarly, details on acquisition protocols and simplified quantification methods are now available for dopamine transporter imaging with PET, including recently developed fluorinated tracers. Finally, [ 18 F]fluorodopa PET is now used in some centers for the differential diagnosis of parkinsonism, although procedural guidelines aiming to define standard procedures for [ 18 F]fluorodopa imaging in this setting are still lacking. Conclusion All these emerging issues are addressed in the present procedural guidelines for dopaminergic imaging in parkinsonian syndromes.

show abstract

“…All patients were scanned in a Siemens Biograph mCT TrueV. Acquisition and reconstruction were performed with the standard protocol for brain studies, as previously described [20]. Informed consent was obtained from all individual participants included in the study.…”

Section: Database Analysismentioning

confidence: 99%

18F-FDG-PET Imaging Patterns in Autoimmune Encephalitis: Impact of Image Analysis on the Results

et al. 2020

Self Cite

View full text Add to dashboard Cite

Brain positron emission tomography imaging with 18Fluorine-fluorodeoxyglucose (FDG-PET) has demonstrated utility in suspected autoimmune encephalitis. Visual and/or assisted image reading is not well established to evaluate hypometabolism/hypermetabolism. We retrospectively evaluated patients with autoimmune encephalitis between 2003 and 2018. Patients underwent EEG, brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) sampling and autoantibodies testing. Individual FDG-PET images were evaluated by standard visual reading and assisted by voxel-based analyses, compared to a normal database. For the latter, three different methods were performed: two based on statistical surface projections (Siemens syngo.via Database Comparison, and 3D-SSP Neurostat) and one based on statistical parametric mapping (SPM12). Hypometabolic and hypermetabolic findings were grouped to identify specific patterns. We found six cases with definite diagnosis of autoimmune encephalitis. Two cases had anti-LGI1, one had anti-NMDA-R and two anti-CASPR2 antibodies, and one was seronegative. 18F-FDG-PET metabolic abnormalities were present in all cases, regardless of the method of analysis. Medial–temporal and extra-limbic hypermetabolism were more clearly depicted by voxel-based analyses. We found autoantibody-specific patterns in line with the literature. Statistical surface projection (SSP) methods (Neurostat and syngo.via Database Comparison) were more sensitive and localized larger hypermetabolic areas. As it may lead to comparable and accurate results, visual analysis of FDG-PET studies for the diagnosis of autoimmune encephalitis benefits from voxel-based analysis, beyond the approach based on MRI, CSF sample and EEG.

show abstract

Brain PET imaging optimization with time of flight and point spread function modelling

Cited by 16 publications

References 24 publications

Impact of point-spread function reconstruction on dynamic and static 18F-DOPA PET/CT quantitative parameters in glioma

Impact of point-spread function reconstruction on dynamic and static 18F-DOPA PET/CT quantitative parameters in glioma

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

18F-FDG-PET Imaging Patterns in Autoimmune Encephalitis: Impact of Image Analysis on the Results

Contact Info

Product

Resources

About