Comparison of the action of cholinomimetics and pentagastrin on gastric secretion in dogs

Abstract

Stimulation of acid secretion by muscarinic cholinomimetic agents depended on the periodic interdigestive activity of the stomach. This explains the peak and following fade. Pentagastrin stimulated gastric secretion after a fixed interval and did not depend on the interdigestive activity. Neither gastrin nor methacholine directly contracted the gallbladder in the doses used. A sustained secretion of gastric acid and pepsin, such as follows a meal, required both hormonal stimulation and gastric distension. The magnitude of the acid response from Heidenhain pouches following meals suggested that pentagastrin doses commonly used experimentally greatly exceed the physiological.

Qualea grandiflora, a Brazilian “Cerrado” medicinal plant presents an important antiulcer activity

“…The suppression of prostaglandins synthesis by nonsteroidal anti-inflammatory drugs (NSAIDS), such as indomethacin, results in increased susceptibility to mucosal injury and gastroduodenal ulceration (Atay et al, 2000). Cholinomimetic agents (bethanechol) administered in association with NSAIDS have a synergistic effect on the gastric injury induced by increased secretion of acid and pepsin in the stomach (Rainsford, 1978;Magee et al, 1985). Significant and dosedependent inhibition of the gastric ulcer was observed from the pre-treatment with HE from Qualea grandiflora.…”

The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice

“…The model of NSAID-induced gastric lesions employed in this study has been developed in mice [6,17] in whom the gastric mucosa is sensitized towards the ulcerogenic effects of the NSAIDs by co-treatment with the cholinomimetic, bethanechol chloride (acetyl-fl-methyl choline chloride), so as to stimulate acid and pepsin production in the stomach [7]. A marked enhancement of NSAID-induced lesions is produced with bethanechol when given at an optimal dose of 5 mg/kg i.p.…”

Gastric Antiulcer Activity of <i>Syngonanthus arthrotrichus</i> S<small>ILVEIRA</small>

“…40) Cholinomimetic agent (bethanechol) administered in association with NSAIDS have a synergistic effect on the gastric injury induced by increased secretion of acid and pepsin in the stomach. 19,41) In the indomethacin/bethanechol-induced ulcer model, cimetidine (100 mg/kg), EEOH (50, 100, 250 mg/kg), FRF and FDF (100 mg/kg) significantly protected the gastric mucous against ulcer formation (Table 4), probably by a mechanism involving increased mucous production.…”