Qualea grandiflora, a Brazilian “Cerrado” medicinal plant presents an important antiulcer activity

Hiruma-Lima, Clélia Akiko; Santos, Lourdes Campaner dos; Kushima, Hélio; Pellizzon, Cláudia Helena; Silveira, Guilherme Garcia da; Vasconcelos, P. C. P.; Vilegas, Wagner; Brito, Alba Regina Monteiro Souza

doi:10.1016/j.jep.2005.09.002

Cited by 68 publications

(49 citation statements)

References 31 publications

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“…O Cerrado Central Brasileiro é uma região biogeográfica dentre as principais do mundo, com mais de 7000 espécies nativas de plantas vasculares e, muitas destas plantas são utilizadas como remédios naturais para o tratamento de diversas doenças, em função dos seus efeitos analgésico, antimicrobiano, anti-úlcera, antiinflamatório e antitumoral (Hiruma-Lima et al, 2006;Napolitano et al, 2005).…”

Section: Introductionunclassified

Avaliação in vitro da atividade fotoprotetora de extratos vegetais do cerrado de Mato Grosso

Violante¹,

Souza²,

Venturini³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:O cerrado brasileiro é um bioma detentor de grande diversidade biológica. No entanto, são escassas as pesquisas de espécies vegetais, especialmente do cerrado mato-grossense, com potencial para serem utilizadas como filtros solares naturais. O objetivo desta pesquisa foi estudar o potencial fotoprotetor de espécies de diferentes famílias (Apocynaceae, Lythraceae, Oxalidaceae) do cerrado da região do Rio Manso, Chapada dos Guimarães -MT. A absorbância dos extratos etanólicos secos foram medidas em diferentes concentrações entre os comprimentos de onda de 260 a 400nm para verificar a absorção nas regiões ultravioleta A e B (UVA e UVB). As plantas que apresentaram absorbância na região estudada foram submetidas a uma análise fitoquímica qualitativa preliminar para determinar a presença de polifenóis e alcalóides, constituintes característicos de plantas que absorvem a radiação UV. Os extratos etanólicos secos que apresentaram absorção em UVB foram submetidos ao teste de determinação in vitro do Fator de Proteção Solar (FPS) desenvolvido por Mansur. M. Velame apresentou absorção na região UVB com absorbância máxima em 318nm, enquanto que a L. pacari e O. hirsutissima apresentaram absorbância na região UVA. Na concentração utilizada e padronizada, nenhuma das espécies apresentou FPS ≥2, sendo assim não podem ser consideradas plantas com potencial fotoprotetor.Unitermos: Apocynaceae, atividade fotoprotetora, Cerrado de Mato Grosso, fator de proteção solar in vitro, Lythraceae, Oxalidaceae.ABSTRACT: "In vitro sunscreen activity evaluation of plants extracts from Mato Grosso cerrado". The Brazilian savanna is a holding biome of large biological diversity. However, the researches of plants species are scarce, especially at the Mato Grosso´s savanna; which have potential to be used as natural sunscreen. The objective of this research was to study the photoprotector potential of several species (Apocynaceae, Lythraceae, Oxalidaceae) from the savanna´s region at the Manso River, Chapada dos Guimarães -MT. The absorbance of dry ethanolic extracts were measured in different concentrations, between waves from 260nm until 400 nm in length. Just to check the absorption in the A and B ultraviolet regions (UVA and UVB). The plants that presented absorbance by the studied area were submitted to a preliminary qualitative phytochemical analysis to determine if there are polyphenols and alkaloids inside, because they are typical constituents of plants that absorber the UV radiation. The dry ethanolic extracts, that presented absorption in UVB, were submitted to a in vitro Sun Protection Factor (SPF) determination test, developed by Mansur. M.velame presented absorption in the UVB region with maximal absorbance at 318 nm, while L. pacari and O. hirsutissima presented absorbance in the UVA region. At the used and standardized concentration, no species presented SPF ≥ 2, so they cannot be considered plants with photoprotector potential.

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Section: Introductionunclassified

Avaliação in vitro da atividade fotoprotetora de extratos vegetais do cerrado de Mato Grosso

Violante¹,

Souza²,

Venturini³

et al. 2009

Rev. bras. farmacogn.

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“…Moreover, mucus is capable of acting as an antioxidant thus can reduce mucosal damage mediated by oxygen free radicals. The protective properties of the mucus barrier depend not only on gel structures but also on the thickness of the layer covering the mucosal layer [25] . A decrease in gastric mucus renders the mucosa susceptible to injuries induced mainly by acids, NSAIDs and alcohol.…”

Section: Discussionmentioning

confidence: 99%

Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Londonkar

Poddar²

2009

WJGO

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AIM:To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid, ethanol and pylorus ligated ulcer models in rats and mice. METHODS:Various crude extracts of petroleum ether, chloroform, or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals. In the pyloric ligation model oral administration of different extracts such as petroleum ether, chloroform and aqueous at 375 mg/kg po , standard drug ranitidine 60 mg/kg po and control group 1% Tween 80, 5 mL/kg po to separate groups of Wister rats of either sex (n = 6) was performed. Total acidity, ulcer number, scoring, incidence, area, and ulcer index were assessed. RESULTS:There was a decrease in gastric secretion and ulcer index among the treated groups i.e. petroleum ether (53.4%), chloroform (59.2%), aqueous (67.0%) and in standard drug (68.7%) when compared to the negative control. In the 0.6 mol/L HCl induced ulcer model in rats (n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether (50.5%), chloroform (57.4%), aqueous (67.5%) and standard. drug (71.2%) when compared to the negative control. In the case of the 90% ethanol-induced ulceration model (n = 6) in mice, there was a decrease in ulcer score in test groups of petroleum ether (53.11%), chloroform (62.9%), aqueous (65.4%) and standard drug ranitidine (69.7%) when compared to the negative control. It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation, 0.6 mol/L HCl and 90% ethanol produced significant action against acid secretion (49.3 ± 0.49 vs 12.0 ± 0.57, P < 0.001). Pre-treatment with various extracts of Mentha arvensisLinn showed highly -significant activity against gastric ulcers (37.1 ± 0.87 vs 12.0 ± 0.57, P < 0.001). CONCLUSION:

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“…The anti-ulcerogenic potentials of fermented aqueous extract of P. macrophylla seed on acetic acid-induced ulcer model in wistar rats was investigated using modified method [18]. A total of fifteen wistar rats (150-200g body weight) was starved for 24 hours and grouped into five groups (Group 1 to V) of three rats each based on their body weights.…”

Section: Acetic Acid-induced Ulcer Studymentioning

confidence: 99%

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

Ugbogu¹,

Arunsi²,

O³

et al. 2017

AJBR

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Pentaclethra macrophylla popularly known as African oil bean is a member of the Leguminosae family.A decoction of fermented extract of the plant has been known to be effective in the management of malnutrition, gastrointestinal disorders and dental caries. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented P. macrophylla seeds using acetic acid, aspirin, ethanol, indomethacin and pyloric ligation of ethanol induced ulcer models at the doses of 400 and 800mg/kg body weight. Omeprazole at 5mg/kg was used as a standard reference drug. The result of the acute toxicity test showed that up to 5,000mg/kg body weight of the extract did not cause any mortality of the animals. The different doses of the extract and the reference drug decreased significantly (p<0.05) the ulcer parameters in a dose-dependent manner in all the ulcer models. The degree of ulcer index for the negative control groups is in the order: Indomethacin (11.10±0.10) < Pyloric-ligation (11.57±0.06) < Aspirin (11.60±0.10)

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Qualea grandiflora, a Brazilian “Cerrado” medicinal plant presents an important antiulcer activity

Cited by 68 publications

References 31 publications

Avaliação in vitro da atividade fotoprotetora de extratos vegetais do cerrado de Mato Grosso

Avaliação in vitro da atividade fotoprotetora de extratos vegetais do cerrado de Mato Grosso

Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Antiulcerogenic Potentials of Fermented Aqueous Extract of <i>Pentaclethra macrophylla</i> (Benth) Seeds

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