Comparison of Tensile Strength and Thrombus Formation between Mechanical Microvascular Anastomoses Using a Biodegradable Ring Device and Sutured Anastomoses

Ichikawa, Makoto; Muneshige, Hiroshi; Ikuta, Yoshikazu

doi:10.1055/s-2002-19895

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…The ratio of vascular thrombosis reported in free flap surgery varies between 5.1% and 9.9% (11-13), and for the prevention of this complication, in addition to the suggestions of agents such as botulinum toxins, low molecular weight heparins, aspirin, prostaglandins, dextran inhibitors, and other various agents (14)(15)(16)(17)(18)(19)(20)(21)(22), studies on anastomosis have also been carried out (23)(24)(25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

An Attempt to Keep Flaps Alive with Artificial Perfusion in Rabbits

Özyazgan¹,

Idaci²,

Kontaş³

2016

Erciyes Med J

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Objective: In free flap surgery, the condition of recipient vessels may not be appropriate for anastomosis because of anatomical factors or acquired features such as tumoral invasion, surgical treatment, or radiotherapy. Furthermore, free flap surgery is time-consuming, expensive, demanding, and more prone to complications. The aim of this study was to test the hypothesis that maintaining free flap perfusion with a temporary artificial system without microanastomosis until revascularization is adequate for flap vitality. Materials and Methods:We studied a total of 14 rabbits, which were placed into two groups: control and experimental. A 5×5 cm free skin island flap was elevated on the caudolateral scapular region. In the experimental group, the artery and vein of the flaps were cannulated and a 5 cc/h plasma infusion was artificially started prior to flap fixation. In the control group, the flaps were designed and sutured to the recipient area without perfusion.Results: The animals did not live long enough for us to analyze the maintenance of the clinical flap vitality. However, it was found that flap tissues in the experimental group were vital during the first 6 days after surgery, while composite graft tissues in the control group resulted in necrosis on day 3 in histopathological examination.Conclusion: Our experimental model proves that the artificial flap perfusion model with plasma perfusion extends the duration of tissue viability compared with that with non-perfusion (control group). This result could be improved with further investigations and may lead to the development of many future innovations.

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Section: Discussionmentioning

confidence: 99%

An Attempt to Keep Flaps Alive with Artificial Perfusion in Rabbits

Özyazgan¹,

Idaci²,

Kontaş³

2016

Erciyes Med J

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“…Die Erfahrungen bei der Verwendung mechanischer Anastomosen zeigen, dass diese die Anastomosierung vereinfachen und das Vorgehen deutlich verkürzen [4]. Darüber hinaus tritt eine Thrombenbildung bei den nahtlosen Anastomosen praktisch nicht mehr auf [3].…”

Section: üBer Die Methoden Der Vereinigung Von Blutgefäßenunclassified

Technik der Gefäßanastomose: Ein Blick in die Geschichte der Entwicklung

Rukosujew¹,

Fugmann²,

Hh³

2006

Thorac cardiovasc Surg

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Die Politik des eisernen Vorhangs führte dazu, dass jahrzehntelang in der Medizin kein wissenschaftlicher Informationsaustausch stattfand. Die von dem russischen Biologen W. P. Demichow an Tieren erfolgreich durchgeführten Experimente waren praktisch bis zum Jahr 1962 im Westen nicht bekannt. Die Veröffentlichung seiner Monographie im Jahre 1962 in englischer Sprache "Experimental Transplantation of Vital Organs" belegt die Anerkennung der Erfolge der medizinischen Wissenschaft in Russland [1].

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Experimental animal studies of clip‐induced microvascular trauma

Kühnel

Müller

2004

Microsurgery

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This study was designed to evaluate microvascular clip potential for causing changes in vessel-wall tissue and the extent to which this potential is influenced by features of the clip. Light and scanning electron microscopy were used to examine vessel-wall changes after temporary clip occlusion. Vessel patency is shown to be influenced by anastomosis and clip site, changes in occlusion force due to material fatigue are described, and novel clip features to reduce vessel trauma are proposed. Evaluation of mechanical clip properties showed that material fatigue does not lead to relevant loss of precision in alpha-type clips. While the modified clip designed to reduce trauma cannot abolish trauma altogether, it significantly reduces the associated changes and hence the risk of thrombosis. Arteries were more sensitive than veins to clip-induced trauma, with increased occlusion force producing more severe damage than increased clipping time. Maximal changes were seen in the tunica media. These results indicate the paramount importance of applying modest clip pressure commensurate with the requirements of microvascular Surgery.

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Comparison of Tensile Strength and Thrombus Formation between Mechanical Microvascular Anastomoses Using a Biodegradable Ring Device and Sutured Anastomoses

Cited by 3 publications

References 14 publications

An Attempt to Keep Flaps Alive with Artificial Perfusion in Rabbits

An Attempt to Keep Flaps Alive with Artificial Perfusion in Rabbits

Technik der Gefäßanastomose: Ein Blick in die Geschichte der Entwicklung

Experimental animal studies of clip‐induced microvascular trauma

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