Comparison of Tamoxifen with Edible Seaweed (<i>Eucheuma cottonii</i><b> </b>L.) Extract in Suppressing Breast Tumor

Shamsabadi, Fatemeh T.; Khoddami, Ali; Fard, Samaneh Ghasemi; Abdullah, Rasedee; Othman, Hemn Hassan; Mohamed, Suhaila

doi:10.1080/01635581.2013.756528

Cited by 29 publications

(20 citation statements)

References 57 publications

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“…EC and seaweeds such as S. binderi, C. lentillifera, and C. racemosa are known to be potent sources of antioxidants [3], [11], [15]- [17]. Furthermore, EC consumption enhances gluthionine (GSH) production [18] and exhibited better antihyperlipaemic and in vivo antioxidant effects as compared to C. lentillifera and S. polycystum seaweeds [7].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of the Sea Bird Nest (Eucheuma Cottonii) and Its Radical Scavenging Effect on Human Keratinocytes

Lim¹,

Koh²,

Haw³

et al. 2015

JOMB

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The potential of Eucheuma cottonii (EC) to be a novel source of antioxidants and protection against photoageing is increasingly evident but largely unexplored. This study aimed to evaluate the antioxidant activity and radical scavenging capacity of EC extracts on human keratinocytes. Aqueous and methanol extracts from EC were evaluated in a series of in vitro assays on the HaCaT keratinocyte cell line. Antioxidant activity was determined via the DPPH assay, while MTT was used to evaluate the cytotoxicity of EC extracts up to 72h exposure. Quantitative and qualitative DCFH-DA fluorescence assays assessed intracellular reactive oxygen species (ROS) levels in UVirradiated cells. EC extracts at concentrations from 10 μg/ml were found to possess significant antioxidant activity (p<0.05). Interestingly, the aqueous extract compromised cell viability at high concentrations, while the methanol extract was relatively non-toxic. Intracellular ROS levels significantly decreased with increasing concentration of EC extract treatment (p<0.05). In conclusion, EC extracts demonstrated antioxidant activity and protective effects against UV-induced ROS degeneration in keratinocytes, thus underlining its potential in nutraceutical research to promote skin rejuvenation. 

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Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of the Sea Bird Nest (Eucheuma Cottonii) and Its Radical Scavenging Effect on Human Keratinocytes

Lim¹,

Koh²,

Haw³

et al. 2015

JOMB

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“…High Urokinasetype plasminogen activator receptor (uPAR) expression predicts for more aggressive disease in several cancer types [167], dietary seaweed may help lowering breast cancer incidence by diminishing levels of uPAR [168]. The tropical edible red seaweed Eucheuma cottonii L. ( Figure 10) is rich in polyphenols that exhibited strong anticancer effect with enzyme modulating properties [169]. Jazzara et al [170] concluded that λ-carrageenan (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [171].…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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“…High Urokinasetype plasminogen activator receptor (uPAR) expression predicts for more aggressive disease in several cancer types [377], dietary seaweed may help lowering breast cancer incidence by diminishing levels of uPAR [378]. The tropical edible red seaweed Eucheuma cottonii L. ( Figure 7d) is rich in polyphenols that exhibited strong anticancer effect with enzyme modulating properties [379]. Jazzara, et al [380] concluded that λ-carrageenan ( Figure 6f) (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [381].…”

Section: Camptotheca Acuminate (Xǐ Shù or Happy Tree) Leavesmentioning

confidence: 99%

Alternative Treatments for Cancer Prevention and Cure [Part 1]

Mohiuddin¹

2019

APCT

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Many lay people along with some so called "key opinion leaders" have a common slogan "There's no answer for cancer". Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of-pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.

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Comparison of Tamoxifen with Edible Seaweed (Eucheuma cottonii L.) Extract in Suppressing Breast Tumor

Cited by 29 publications

References 57 publications

Antioxidant Activity of the Sea Bird Nest (Eucheuma Cottonii) and Its Radical Scavenging Effect on Human Keratinocytes

Antioxidant Activity of the Sea Bird Nest (Eucheuma Cottonii) and Its Radical Scavenging Effect on Human Keratinocytes

Seaweeds: An Extensive Review of Medicinal Values

Alternative Treatments for Cancer Prevention and Cure [Part 1]

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