Comparison of surgery and surgery plus corticosteroid therapy in idiopathic granulomatous mastitis, prospective randomized study

Patmano, Mehmet; Akçan, Alper; Öz, Abdullah Bahadır; Arıkan, Tamer; Doğan, Serap; Gün, İskender; Sözüer, Erdoğan

doi:10.5455/annalsmedres.2019.09.533

Cited by 2 publications

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“…Studies have been conducted in this regard; for example, in the study of Azizi et al (16) in 2019, the recurrence rate was 24.8, and breast skin lesions were more likely to recur, which was much higher than in our study. In another study by Patmano et al (5), in 2019, patients were treated surgically with/without corticosteroids, which had a lower recurrence in the surgical group (6.7%) than in the steroid group (20%) during follow-up. However, no significant difference was observed between the groups.…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Granulomatous Mastitis (IGM): Clinical Features and Non-Surgical Management

et al. 2023

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Background: Idiopathic Granulomatous Mastitis (IGM) is a benign disease; it can clinically and radiologically mimic the symptoms of breast cancer. Objectives: Due to the rare and limited number of studies in Iran, this study was designed and conducted to evaluate patients' clinical characteristics and treatment management with IGM. Methods: In this cross-sectional and retrospective descriptive-analytic study, we studied the medical records of 293 patients with IGM, such as demographic information, characteristics of breast lesions, type of treatment, complications, and their outcome, which were recorded in the Cancer Research Centers of Shahid Beheshti University of Medical Sciences (SBMU) from 2010 to 2019. The patients were contacted by telephone to visit clinically or collect additional information. Data were analyzed by SPSS software version 24. Results: The mean age of patients was 39.21 (ST = 8.29) years. Breast involvement in 236 cases (80.5%) was unilateral, and in 50 cases (17.1%), the involvement was Pere pri-Areola. The most common type of treatment was conservative therapy (analgesia + drainage) (178 cases, 60.8%), which was the primary treatment in our study; 66 patients (22.5%) received antibiotic therapy + analgesia + drainage, and 41(14%) cases received corticosteroid in addition to this treatment. Totally, 132 cases (79.5%) were completely cured with the performed treatments, 17 cases (5.8%) had a recurrence of symptoms, and 14.7% of the patients were still receiving treatment. Recurrence after 1 year in patients who had a longer duration of disease (more than 12 months) was higher than in those who had a shorter period (less than 12 months) (15.3% vs. 5.1%, P = 0.004). Also, the highest recurrence rate was in the group receiving corticosteroids compared to the group receiving the usual treatment and usual treatment plus antibiotics. This relationship was statistically significant (22.0% vs. 9 % and 6.1%, respectively, P = 0.032). Complications (scar or breast skin color change) were significantly higher in patients without a pregnancy history than in patients who had pregnancy (50.0% vs. 22.8%, P = 0.030). Also, these complications were significantly higher in patients who had a longer duration of disease (more than 12 months) than in shorter periods of disease (less than 12 months) (31.4% vs. 17.3%, P = 0.005). Conclusions: The results of our study and its comparison with the results of other studies still emphasize the uncertainty of the etiology of IGM disease and its treatment, but to some extent, our study has shown that conservative treatment (drainage with analgesic drugs) is one of the best treatment options. Also, corticosteroid therapy is associated with a higher recurrence rate, but in some cases is necessary and recommended in many studies.

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Section: Discussionmentioning

confidence: 99%

“…However, it has been reported in Nulliparous women and men (4). Various studies have reported that IGM accounts for 24% of all inflammatory breast disorders, with an annual incidence of 2.4: 100,000 in women (5).…”

Section: Introductionmentioning

confidence: 99%