Comparison of supercritical fluid chromatography and reverse phase liquid chromatography for the impurity profiling of the antiretroviral drugs lamivudine/BMS-986001/efavirenz in a combination tablet

Alexander, A. J.; Zhang, L.; Hooker, T.F.; Tomasella, Frank P.

doi:10.1016/j.jpba.2013.02.019

Cited by 39 publications

(27 citation statements)

References 21 publications

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“…Only recently, with the advances in SFC instrumentation, this technique could be applied for quantitative purposes [23,87] and for impurity profiling providing sufficient sensitivity for the impurities, which should be monitored at 0.05-0.1% of API area [96][97][98]. The first full validation of an UHPSFC method considering total error approach was published by Dispas et al [23] for antibiotic drugs.…”

Section: Application Of Sfc To the Achiral Analysis Of Drug Substancementioning

confidence: 99%

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Supercritical fluid chromatography in pharmaceutical analysis

Desfontaine

Guillarme

Francotte

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

204

102

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Section: Application Of Sfc To the Achiral Analysis Of Drug Substancementioning

confidence: 99%

“…This enabled the applicability of SFC for impurity profiling at 0.1% of API with drug loading concentrations of 2 mg/mL. Later on, Alexander et al [96] compared SFC and RPLC for impurity profiling of antiretroviral drugs in a dual and triple combination tablet formulations (Fig. 6).…”

Section: Application Of Sfc To the Achiral Analysis Of Drug Substancementioning

confidence: 99%

Supercritical fluid chromatography in pharmaceutical analysis

Desfontaine

Guillarme

Francotte

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

204

102

View full text Add to dashboard Cite

“…Indeed, apart from its preponderant involvement in chiral and preparative separations already discussed, SFC penetrates gradually into the R&D and QC laboratories. The development of qualitative and quantitative methods orthogonal to LC for QC purposes has been recently described [287]. The range of compounds that can be analyzed with SFC is also expanded with the development of methodology for the analysis of highly polar or ionic compounds.…”

Section: Current Trends In Sfcmentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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Abstract:The current trend in high performance liquid chromatography (HPLC) tends toward the achievement of higher separation efficiency and shorter analysis time. Indeed, better performance in LC has become increasingly important in recent years mainly driven by the challenges of either analyzing more complex samples or increasing the numbers of samples per time unit. In the recent development of particle technology, the use of fully porous sub-2 m particles and sub-3 m shell particles have received considerable attention. Beside packed columns, the new generation of silica-based monolithic columns also offers very high separation power. However, to take full advantage of these innovative phases, the chromatographic system has also to be drastically optimized in terms of upper pressure limit and system volume.This revolution in column technology now spreads and covers several modes of liquid chromatography such as reversedphase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC), or even supercritical fluid chromatography (SFC). The HILIC and SFC, which can be considered as alternative modes of chromatography, could also be useful to extend the applicability of chromatography towards the analysis of very hydrophilic and lipophilic compounds, respectively.The present review gives an insight about the theory behind the success of current column technology and presents a summary of latest applications, using various modes of one-dimensional chromatography (RPLC, HILIC, SFC). This paper also shows that theoretically expected column efficiency could sometimes be compromised in practical work especially in the case of narrow bore columns.

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“…Compared to both liquid chromatography (LC) and gas chromatography (GC), SFC, which utilized supercritical fluids as the mobile phase, exhibited special retention behaviours and selectivity of analytes [3][4][5] . The potential benefits of analytical SFC gradually attracted widespread attentions by analysts.…”

Section: Introductionmentioning

confidence: 99%

The use of ionic liquid as a mobile phase modifier in analytical supercritical fluid chromatography for the separation of flavonoids

et al. 2016

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Due to the low viscosity of the carbon dioxide, supercritical-fluid chromatography (SFC) allows higher flow rates with lower back pressure, usually analytical SFC can provide much faster and more efficient separation compared to conventional chromatographic methods. The non-polar character of supercritical carbon dioxide (scCO2) limited SFC in separate hydrophobic compounds, but various modifiers can be used to improve the selectivity of SFC. Ionic liquids (ILs) exhibits various features including wide range of solubility, miscibility, high thermal stability, and low vapor pressure, were widely used as additive to modify the character of mobile phase, but the performance of ILs in improving SFC separation has not been evaluated. In this work, analytical SFC was applied for the separation of six flavonoid aglycones, 1-butyl-3-methyl imidazolium-based ILs were tested and compared as the mobile phase additives. ILs could significantly improve the resolution of flavonoid aglycones and the selectivity changed probably based on the hydrogen-bonding interaction.

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Comparison of supercritical fluid chromatography and reverse phase liquid chromatography for the impurity profiling of the antiretroviral drugs lamivudine/BMS-986001/efavirenz in a combination tablet

Cited by 39 publications

References 21 publications

Supercritical fluid chromatography in pharmaceutical analysis

Supercritical fluid chromatography in pharmaceutical analysis

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

The use of ionic liquid as a mobile phase modifier in analytical supercritical fluid chromatography for the separation of flavonoids

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