Comparison of <sup>13</sup>C MRI of hyperpolarized [1‐<sup>13</sup>C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model

Fala, Maria; Somai, Vencel; Dannhorn, Andreas; Hamm, Grégory; Gibson, Katherine; Couturier, Dominique‐Laurent; Hesketh, Robin; Wright, Alan J.; Takáts, Zoltán; Bunch, Josephine; Barry, Simon T.; Goodwin, Richard J. A.; Brindle, Kevin M.

doi:10.1002/mrm.28652

Cited by 10 publications

(3 citation statements)

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“…In contrast, a mass spectrometry imaging study on EL4 tumor sections showed that there was no correlation between the distribution of 13 C-labeled and unlabeled lactate in the tumors. However, there was a strong correlation between labeled pyruvate and lactate in the corresponding 13 C MR images acquired in vivo, suggesting that in the EL4 tumor, pyruvate delivery is more important [ 37 ]. The relative importance of pyruvate delivery and transport and lactate dehydrogenase activity in determining the rate of hyperpolarized 13 C label exchange between pyruvate and lactate appears to vary between different tumor types.…”

Section: In Vitro and In Vivo Experiments With Hp 13 ...mentioning

confidence: 99%

Hyperpolarized Carbon-13 MRI in Breast Cancer

Woitek

Brindle

2023

Diagnostics

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One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C-MRI) has been shown to be a potentially versatile tool for the clinical evaluation of tumor metabolism. Hyperpolarization of the 13C nuclear spin can increase the sensitivity of detection by 4–5 orders of magnitude. Therefore, following intravenous injection, the location of hyperpolarized 13C-labeled pyruvate in the body and its subsequent metabolism can be tracked using 13C-MRI. Hyperpolarized [13C]urea and [1,4-13C2]fumarate are also likely to translate to the clinic in the near future as tools for imaging tissue perfusion and post-treatment tumor cell death, respectively. For clinical breast imaging, HP 13C-MRI can be combined with 1H-MRI to address the need for detailed anatomical imaging combined with improved functional tumor phenotyping and very early identification of patients not responding to standard and novel neoadjuvant treatments. If the technical complexity of the hyperpolarization process and the relatively high associated costs can be reduced, then hyperpolarized 13C-MRI has the potential to become more widely available for large-scale clinical trials.

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Section: In Vitro and In Vivo Experiments With Hp 13 ...mentioning

confidence: 99%

Hyperpolarized Carbon-13 MRI in Breast Cancer

Woitek

Brindle

2023

Diagnostics

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“…The technique used and the cancer‐specific biomarkers identified could serve as the basis for new diagnostic strategies for prostate cancer categorization. Numerous other AIMS techniques have been applied to detect cancer‐related biomarkers in biological samples, including PESI for the detection of colorectal liver metastasis 27 and DESI for prostate cancer and lymphoma detection 28,29 …”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

“…Numerous other AIMS techniques have been applied to detect cancer‐related biomarkers in biological samples, including PESI for the detection of colorectal liver metastasis 27 and DESI for prostate cancer and lymphoma detection. 28 , 29 …”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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Analysis and visualization of hyperpolarized 13C MR data

Bankson¹,

Larson²

2021

Advances in Magnetic Resonance Technology and Applications

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Comparison of ¹³C MRI of hyperpolarized [1‐¹³C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 30 publications

Hyperpolarized Carbon-13 MRI in Breast Cancer

Hyperpolarized Carbon-13 MRI in Breast Cancer

Applications of ambient ionization mass spectrometry in 2021: An annual review

Analysis and visualization of hyperpolarized 13C MR data

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Comparison of 13C MRI of hyperpolarized [1‐13C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 30 publications

Hyperpolarized Carbon-13 MRI in Breast Cancer

Hyperpolarized Carbon-13 MRI in Breast Cancer

Applications of ambient ionization mass spectrometry in 2021: An annual review

Analysis and visualization of hyperpolarized 13C MR data

Contact Info

Product

Resources

About

Comparison of ¹³C MRI of hyperpolarized [1‐¹³C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model