Comparison of Sulfur Hexafluoride Microbubble (SonoVue)-Enhanced Myocardial Contrast Echocardiography With Gated Single-Photon Emission Computed Tomography for Detection of Significant Coronary Artery Disease

Abstract

SonoVue-enhanced MCE demonstrated superior sensitivity but lower specificity for detection of CAD compared to SPECT in a population with a high incidence of CV risk factors and intermediate-high prevalence of CAD. (A phase III study to compare SonoVue® enhanced myocardial echocardiography [MCE] to single photon emission computerized tomography [ECG-GATED SPECT], at rest and at peak of low-dose Dipyridamole stress test, in the assessment of significant coronary artery disease [CAD] in patients with suspect or known CAD using Coronary Angiography as Gold Standard-SonoVue MCE vs SPECT; EUCTR2007-003492-39-GR).

Three- or four-dimensional hysterosalpingo contrast sonography for diagnosing tubal patency in infertile females: a systematic review with meta-analysis

“…The included studies used a newer generation of ultrasound contrast agent SonoVue (sulfur hexafluoride microbubbles), which has been widely applied in heart and blood vessel angiography. 39,40 Moreover, 3D/4D HyCoSy also provides an adequate evaluation for the uterine cavity. 5 But, the cost of both the new machine and contrast medium is considerable in clinical practice.…”

2013 Esc Guidelines on the Management of Stable Coronary Artery Disease

“…Физические упражнения обеспечивают более физиологические условия, чем фармакологиче-ские методы, и дают дополнительную информацию о физиологии, например, о времени длительности выполнения пробы и рабочей нагрузке, а также об изменениях ЧСС, АД и ЭКГ. Таким образом, при что позволяет получить дополнительную информа-цию вдобавок к оценке утолщения стенки во время стресс-ЭхоКГ как с введением вазодилататора, так и с инотропной нагрузкой [122,123]. Такой подход, однако, широко не используется клинически.…”

Myocardial Contrast Echocardiography: Ready for the prime time

“…A meta-analysis of eight studies 11 comparing sensitivity and specificity of MCE with those of SPECT/ dobutamine stress echocardiography for the detection of stable CAD showed superior sensitivity of MCE vs SPECT 1 . Recent multicentre studies confirmed these observations 1,12 . The superior sensitivity of MCE is due to its better spatial and temporal resolution compared to SPECT.…”