Comparison of Substances Used for Prevention of Intra-Abdominal Adhesions: An Experimental Study in Rats

Günaydın, Mithat; Güvenç, Dilek; Yıldız, Levent; Aksoy, Abdurrahman; Tander, Doç.Burak; Bıçakçı, Ünal; Ayyıldız, Hakan; Sünter, Doç.A.Tevfik; Arıtürk, Ender; Rizalar, Rıza; Bernay, Ferit

doi:10.5336/medsci.2011-22902

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Peritoneal lavage, although previously attempted in the treatment of intra-abdominal infections and adhesions, does not have precise results. Various studies [4,13,14] have reported the use of saline, antibiotic and fibrinolytic agents given during peritoneal lavage. Today, there is no universally accepted peritoneal lavage method and solution.…”

Section: Discussionmentioning

confidence: 99%

An evaluation of the effect of ertapenem in rats with sepsis created by cecal ligation and puncture

Serin¹,

Köse

Yılmaz

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Intra-abdominal adhesions are still a major problem which is expected to be reduced by the provision of bacterial decontamination. Various antibiotics have been used to prevent the formation of adhesion in the septic abdomen. This study aims to investigate the efficacy of ertapenem in sepsis of rats induced by cecal ligation and puncture. METHODS: Twenty-eight Wistar rats were divided into four groups randomly. In all groups, bacterial peritonitis was created by cecal ligation and puncture method. Group 1 was considered as sham group. Groups 2, 3 and 4 were given, respectively, saline, a single dose of ertapenem and a dose of ertapenem intraperitoneally every day. Intra-abdominal adhesions were assessed seven days after surgery by histopathological examination. Microbiological examination was performed through the ascites obtained. TNF-α was measured from blood taken from rats. RESULTS: Adhesion score decreased significantly by the application of ertapenem (p<0.001) and fibrosis scores were found to be significantly lower (p=0.005). Among all groups, the relationship between the decrease in the number of colonies and antibiotics application was not statistically significant (p=0.109). No statistically significant difference was found between the group given a single dose of ertapenem and the group given multiple ertapenem (p=1). CONCLUSION: Peritoneal lavage with ertapenem appears to be effective in preventing the adhesion in the septic abdomen. As no difference was detected at the end of a single dose and multiple-dose administration of antibiotics in the adhesion scores, a single dose after surgery seems to be enough. The findings suggest that the results should be evaluated in a clinical trial.

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Section: Discussionmentioning

confidence: 99%

An evaluation of the effect of ertapenem in rats with sepsis created by cecal ligation and puncture

Serin¹,

Köse

Yılmaz

et al. 2018

Ulus Travma Acil Cerrahi Derg

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“…The histological sections were examined for the presence of periserozal inflammation, fibroblastic activity and foreign body reaction with a light microscope (Nikon Optiphot, Kanagawa, Japan) and photographed. In histopathological evaluation, the previously defined criteria defined by Gunaydın et al were used [14].…”

Section: Histopathological Evaluationmentioning

confidence: 99%

Antienflamatuar and antiadhesive effect of clioquinol

Yıldız

İlçe

Yıldırım

et al. 2015

International Journal of Surgery

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“…Other reports indicate that peritoneal lavage promotes adhesion formation, as opposed to reports that suggested a preventive role for peritoneal lavages in adhesion formation. [26][27][28] Antibiotics can exert their anti-adhesive effects by inhibition of synthesis or expression of adhesins on the bacterial cell surface, or modify bacterial protein expression in such a way as to interfere with the ability of the microorganisms to approach receptors on animal cell surface. [29] Sortini et al [5] compared the efficacy of peritoneal lavage with chloramphenicol, clindamycin, piperacillin, tobramycin, ceftriaxone and imipenem-cilastatin to saline, with adhesion formation increased in study groups.…”

Section: Discussionmentioning

confidence: 99%