Comparison of Subdermal and Peritumoral Injection Techniques of Lymphoscintigraphy to Determine the Sentinel Lymph Node in Breast Cancer

Abstract

The success rate was found to be higher with the SD injection technique than with PT injections to visualize the axillary SLN. To increase the visualization of both axillary and IM SLNs, it may be useful to perform lymphoscintigraphy with SD and PT injections together.

Factors predicting the sentinel and non-sentinel lymph node metastases in breast cancer

“…After 2002, however, the remaining 172 patients underwent CAD only, if the SLN was positive. Lymphatic mapping was performed using isosulphan blue dye alone (n=210) or in addition to a technetium Tc 99 m sulfur colloid technique (n=190) as described previously [23]. In the latter technique, patients received a peri-areolar injection of rhenium sulphate labelled with 99 m Tc (Nanacis, CIS Bio International) at least 2 h before surgery, and lymphoscintigraphy was also performed in the Department of Nuclear Medicine 2 h after the injection on the day of the surgery.…”

Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer model

“…route, supporting the potential of the approach in the treatment of localregional nodes clinically involved with metastatic disease or, indeed, clinically uninvolved lymph nodes suspected of harboring micrometastatic disease. During recent studies on sentinel lymph node identification, there was clear evidence for the hypothesis that substances injected interstitially may imitate the patterns of lymphatic spread of breast cancer (Jansen et al 2000, Eroglu et al 2004.…”

Détection du ganglion sentinelle chez les patientes atteintes d’un cancer du sein à un stade précoce : quel site d’injection en 2011 ?

“…L'injection pé ritumorale profonde, du fait du drainage lymphatique profond vers les chaînes mammaires internes et externes, permettrait quant à lui de visualiser plus fré quemment les GS de la chaîne mammaire interne [15]. Dans une sé rie de 36 patientes ayant reçu à huit jours d'intervalle une injection de traceur radioactif en pé ritumoral, puis en superficiel, Eroglu et al ont montré un taux d'identification en lymphoscintigraphie des GS extra-axillaires au niveau de la chaîne mammaire interne plus fré quents avec l'injection profonde (23 % versus 10 %).…”