Comparison of stress response following microwave ablation and surgical resection of benign thyroid nodules

Liu, Shuyan; Guo, Weihong; Yang, Bo; Li, Yongfeng; Huang, Xiaofeng; Wang, Xiaoqing; Chen, Jie; Dong, Xue; Zhou, Xue-hong

doi:10.1007/s12020-019-01900-5

Cited by 17 publications

(15 citation statements)

References 19 publications

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“…By 12 months, about 1/ 4 of nodules have completely disappeared. Comparison of thyroid function before treatment and 1 month after MWA shows that the difference is not statistically significant, which indicates that the treatment with MWA does not affect the thyroid function of patients consistent with the study of Liu [33].…”

Section: Discussionsupporting

confidence: 79%

A study on the efficacy of microwave ablation for benign thyroid nodules and related influencing factors

Kang

et al. 2021

International Journal of Hyperthermia

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Objectives: To explore the efficacy of microwave ablation (MWA) in the treatment of benign thyroid nodules, and analyze related influencing factors. Methods: The clinical and ultrasound data of 115 patients with 115 benign thyroid nodules treated with MWA were retrospectively analyzed. The volume of nodules at 1, 3, 6, and 12 months after the procedure was obtained, and the volume reduction rate (VRR) at each time point was calculated. With VRR > 90% as the criterion for nodule cure, binary logistic regression was employed to screen the factors that affect the efficacy. Results: ‹ At 1, 3, 6, and 12 months after the procedure, the volume of nodules continued to decrease, the VRR gradually increased, and the differences at each time point were statistically significant (p < 0.05). A total of 29 (25.21%) nodules disappeared completely at 12 months after the procedure; › Multivariate stepwise logistic regression showed that there was a statistically significant difference for the internal component of nodules, enhancement mode, and immediate volume after the procedure in determining the ablation efficacy (p < 0.05); fi The ROC curve was plotted for predicting the efficacy of MWA, with the results showing that the AUC, sensitivity, specificity, and accuracy were 0.82, 67.50, 88.00, 79.10%, respectively; fl 11 cases (9.56%) had side effects, 10 cases (8.70%) had minor complications, and three cases (2.61%) had major complications. Conclusion: MWA is safe and effective in the treatment of benign thyroid nodules. The internal component of nodules, enhancement mode, and immediate volume after the procedure are independent factors that affect the efficacy of ablation.

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Section: Discussionsupporting

confidence: 79%

A study on the efficacy of microwave ablation for benign thyroid nodules and related influencing factors

Kang

et al. 2021

International Journal of Hyperthermia

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“…Treatment options for MWA and HIFU are still being evaluated. Liu, Sy et al [ 35 ] pointed out that stress response of ultrasound-guided MWA to treat with nodules was significantly lesser than that of surgery. Postoperative IL-6, IL-8 and TNF in MWA group were lower than those in surgery group (P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Conspicuousness and recurrence related factors of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules

Xia

Wang

et al. 2021

BMC Surg

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Objective Microwave ablation (MWA) is a minimally invasive technique for the treatment of benign thyroid nodules. The purpose of this study was to evaluate efficacy and safety of ultrasound-guided MWA in the treatment of benign thyroid nodules, and to find out the recurrence related factors, so as to provide reference for future clinical work. Methods This study retrospectively analyzed the patients who received ultrasound-guided MWA for benign thyroid nodules in our hospital from October 2018 to March 2020. A total of 214 patients were included in the study. We assessed thyroid volume changes (represented by volume reduction ratio VRR), the energy per 1 mL reduction in nodular volume (represented by energy volume ratio ΔE), the serum levels of free triiodide thyroid hormone (FT3), free thyroxine (FT4), thyrotropin (TSH) and complications after MWA treatment. Results There were a total of 306 nodules in 214 patients, including 183 (85.51%) females and 31 (14.49%) males. The median diameter and volume of the nodule were 33 mm and 8.01 mL. The VRR at 1 month, 3 months, 6 months and 12 months were 40.79%, 60.37%, 74.59% and 85.60%, respectively. In addition, MWA had a better ablation effect for small nodules (initial volume ≤ 10 mL). In recurrent studies, we found that ΔE was an independent risk factor for benign thyroid nodules (P < 0.05). Conclusions Ultrasound-guided MWA is effective and safe in the treatment of benign thyroid nodules. In addition, it has little damage to surrounding tissues and no effect on thyroid function. Especially, the nodules with smaller initial volume, the treatment is better. On the other hand, the energy per 1 mL reduction ΔE in nodular volume may be associated with nodular recurrence, which requires further follow-up for longer periods. At this stage, we consider that ultrasound-guided MWA can be used as one of the main clinical treatment methods for benign thyroid nodules.

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“…Another question remain unveiled was if our result was "cancer-specific". We checked literature about cytokine modulation after thermal ablation in benign diseases and only got limit evidences based on benign thyroid nodules [30] and adenomyosis [31]. According to these literature, IL-6 levels did not show any significant difference after treatment compared with pretreatment values, indicating that elevation of IL-6 may be caused by tumour antigen released by ablation treatment.…”

Section: ± 806mentioning

confidence: 99%

Effect of microwave ablation treatment of hepatic malignancies on serum cytokine levels

Zhao

Muktiali

et al. 2020

BMC Cancer

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Background: Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ site but also an immunoreaction of the whole body. This study aimed to investigate the effects of MWA on cytokines in patients who underwent MWA for a hepatic malignancy. Methods: Patients admitted to the Oncology Department in the First Affiliated Hospital of Soochow University between June 2015 and February 2019 were selected. Peripheral blood was collected from patients with a hepatic malignancy treated with MWA. The levels of cytokines (IL-2, IFN-γ, TNF-α, IL-12 p40, IL-12 p70, IL-4, IL-6, IL-8, IL-10, and vascular endothelial growth factor (VEGF)) were detected with a Milliplex® MAP Kit. The comparison times were as follows: before ablation, 24 h after ablation, 15 days after ablation, and 30 days after ablation. Data were analyzed using a paired sample t-tests and Spearman's correlation analysis. Results: A total of 43 patients with hepatic malignancies were assessed. There were significant differences in IL-2, IL-12 p40, IL-12 p70, IL-1β, IL-8, and TNF-α at 24 h after MWA. Significant increases (> 2-fold vs. before ablation) were observed in IL-2, IL-1β, IL-6, IL-8, IL-10, and TNF-α after MWA. Elevated IL-2 and IL-6 levels after ablation were positively correlated with energy output during the MWA procedure. Conclusions: WA treatment for hepatic malignancies can alter the serum levels of several cytokines such as IL-2 and IL-6.

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Comparison of stress response following microwave ablation and surgical resection of benign thyroid nodules

Cited by 17 publications

References 19 publications

A study on the efficacy of microwave ablation for benign thyroid nodules and related influencing factors

A study on the efficacy of microwave ablation for benign thyroid nodules and related influencing factors

Conspicuousness and recurrence related factors of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules

Effect of microwave ablation treatment of hepatic malignancies on serum cytokine levels

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