Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

Mátyás, Csaba; Kovács, Attila; Németh, Balázs Tamás; Oláh, Attila; Braun, Szilveszter; Tokodi, Márton; Barta, Bálint András; Benke, Kálmán; Ruppert, Mihály; Lakatos, Bálint Károly; Merkely, Béla; Radovits, Tamás

doi:10.1186/s12933-017-0645-0

Cited by 41 publications

(32 citation statements)

References 42 publications

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“…Our findings indicated that hemodynamic parameters such as systolic, diastolic, and mean blood pressures were altered in DC and DC + ISO rats due to the consecutive loss of cell membrane potential in injured myocardium. The results are in line with the previous reports (Ishikawa et al, ; Kalkan et al, ; Mátyás et al, ). Moreover, KF treatment improved systolic, diastolic, and mean blood pressures in DC + ISO rats.…”

Section: Discussionsupporting

confidence: 94%

The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

Zhang

Guo

Wang

et al. 2019

Drug Development Research

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This study was designed to delineate the effect of kaempferol (KF) on heart failure (HF) in diabetic rats. Streptozotocin‐induced male diabetic rats received KF orally at 10 and 20 mg/kg for 42 consecutive days. In last 2 days of the experimental period, isoproterenol was subcutaneously injected at 85 mg/kg to induce HF. The hearts were processed for hemodynamic, biochemical, molecular, and histological investigations. Systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were elevated in KF‐treated HF‐induced diabetic rats. Moreover, KF treatment resulted in decreased fasting blood glucose and glycosylated hemoglobin levels with increased serum insulin levels. Besides, serum cardiac injury markers like troponin‐I, creatine kinase‐muscle/brain, lactate dehydrogenase, and brain natriuretic peptide levels were significantly reduced in KF treatment. KF treatment has shown decrease in cardiac heme oxygenase‐1, nuclear factor erythroid 2–related factor 2 (Nrf‐2), and γ‐glutamylcysteine synthetase with increased Keap1 mRNA levels. The cardioprotection of KF was improved by inhibition of apoptosis via blocking phosphorylation of Akt/glycogen synthase kinase (GSK)‐3β and p38 mitogen‐activated protein‐kinase/extracellular signal‐regulated kinases signaling pathways in HF‐induced diabetic rats. Moreover, reduced cardiac apoptosis in KF treatment was confirmed by decreased terminal deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) positive cells, histopathological changes in HF‐induced diabetic rats. Therefore, the cardioprotective effect of KF is attributed to the regulation of Nrf2, nuclear factor kappa‐light‐chain‐enhancer of activated B cells, and Akt/GSK‐3β signaling pathways in HF‐induced diabetic rats.

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Section: Discussionsupporting

confidence: 94%

The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

Zhang

Guo

Wang

et al. 2019

Drug Development Research

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“…Speckle-tracking echocardiography emerged as a valuable tool for a more quantitative, semi-automated approach. Global longitudinal strain is showing an established diagnostic and prognostic value regarding LV pathologies [ 8 ], and promising data also have been gathered for the RV [ 9 ]. Although the RV longitudinal strain has an established added prognostic value compared to TAPSE, longitudinal strain still incorporates only one motion direction.…”

Section: Advanced Echocardiographic Techniques To Characterize Rv Mecmentioning

confidence: 99%

Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening

et al. 2019

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Right ventricular (RV) function has proven to be a prognostic factor in heart failure with reduced and preserved ejection fraction and in pulmonary hypertension. RV function is also a cornerstone in the management of novel clinical issues, such as mechanical circulatory support devices or grown-up congenital heart disease patients. Despite the notable amount of circumferentially oriented myofibers in the subepicardial layer of the RV myocardium, the non-longitudinal motion directions are often neglected in the everyday assessment of RV function by echocardiography. However, the complex RV contraction pattern incorporates different motion components along three anatomically relevant axes: longitudinal shortening with traction of the tricuspid annulus towards the apex, radial motion of free wall often referred as the “bellows effect”, and anteroposterior shortening of the chamber by stretching the free wall over the septum. Advanced echocardiographic techniques, such as speckle-tracking and 3D echocardiography allow an in-depth characterization of RV mechanical pattern, providing better understanding of RV systolic and diastolic function. In our current review, we summarize the existing knowledge regarding RV mechanical adaptation to pressure- and/or volume-overloaded states and also other physiologic or pathologic conditions.

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“…However, the link between myocardial deformation and underlying changes in structural proteins in the context of diabetic cardiomyopathy is still little explored. Only a few studies 5,24,35 have determined global LV function via strain parameters in the context of experimental diabetic cardiomyopathy so far. Therefore, the aim of our study was to evaluate myocardial deformation in combination with the underlying changes in the expression of structural components during the pathogenesis of STZ-induced type 1 diabetes mellitus-associated diabetic cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Speckle-tracking echocardiography combined with imaging mass spectrometry assesses region-dependent alterations

Pappritz

Grune

Klein

et al. 2020

Sci Rep

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Left ventricular (LV) contraction is characterized by shortening and thickening of longitudinal and circumferential fibres. To date, it is poorly understood how LV deformation is altered in the pathogenesis of streptozotocin (STZ)-induced type 1 diabetes mellitus-associated diabetic cardiomyopathy and how this is associated with changes in cardiac structural composition. To gain further insights in these LV alterations, eight-week-old C57BL6/j mice were intraperitoneally injected with 50 mg/kg body weight STZ during 5 consecutive days. Six, 9, and 12 weeks (w) post injections, echocardiographic analysis was performed using a Vevo 3100 device coupled to a 30-MHz linearfrequency transducer. Speckle-tracking echocardiography (STE) demonstrated impaired global longitudinal peak strain (GLS) in STZ versus control mice at all time points. 9w STZ animals displayed an impaired global circumferential peak strain (GCS) versus 6w and 12w STZ mice. They further exhibited decreased myocardial deformation behaviour of the anterior and posterior base versus controls, which was paralleled with an elevated collagen I/III protein ratio. Additionally, hypothesis-free proteome analysis by imaging mass spectrometry (IMS) identified regional-and time-dependent changes of proteins affecting sarcomere mechanics between STZ and control mice. In conclusion, STZ-induced diabetic cardiomyopathy changes global cardiac deformation associated with alterations in cardiac sarcomere proteins. Diabetic cardiomyopathy is an own clinical entity, which occurs in the absence of hypertension and coronary artery disease 1,2. Experimental STZ-induced type 1 diabetes mellitus-associated diabetic cardiomyopathy is associated with enhanced cardiac cytokine levels and collagen I deposition, resulting in cardiac dysfunction 3. Cumulative evidence shows that early diabetic cardiomyopathy manifests in LV diastolic dysfunction accompanied by low-grade inflammation lacking pronounced fibrosis 4. Imaging techniques, like echocardiography 5 facilitate detection of alterations in diastolic performance. In general, LV architecture is composed of longitudinal and circumferential fibres, building the endo-, meso-, and epicardial layers of the heart 6. The orientation of the fibres within those layers is comprised of a right-handed helix in the subendocardium, circumferential oriented fibres in the cardiac midwall, and a left-handed helix in the subepicardium 7. During cardiac contraction, fibres undergo shortening and thickening, whereby contraction of the subendocardial longitudinal fibres mainly determine LV function in longitudinal direction 8. In contrast,

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Comparison of speckle-tracking echocardiography with invasive hemodynamics for the detection of characteristic cardiac dysfunction in type-1 and type-2 diabetic rat models

Cited by 41 publications

References 42 publications

The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

The protective effect of kaempferol on heart via the regulation of Nrf2, NF‐κβ, and PI3K/Akt/GSK‐3β signaling pathways in isoproterenol‐induced heart failure in diabetic rats

Right ventricular mechanical pattern in health and disease: beyond longitudinal shortening

Speckle-tracking echocardiography combined with imaging mass spectrometry assesses region-dependent alterations

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