Comparison of specific in-vitro virulence gene expression and innate host response in locally invasive vs colonizer strains of Streptococcus pneumoniae

Fuji, Naoko; Pichichero, Michael E.; Kaur, Ravinder

doi:10.1007/s00430-021-00701-w

Cited by 1 publication

(1 citation statement)

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“…Interestingly, the problems with serotype distribution based on geographical location can impact a protein-based vaccine too. A study using PCR detection of many of the discussed pneumococcal surface proteins observed non-uniform presence of multiple proteins originally expected to be conserved ( Blumental et al., 2015 ), while another study showed downregulation of PcpA and PhtE and no changes in PLY, PspA, or PhtD when comparing serotypes 15A and 35B, two serotypes with increasing incidence rates and outside of PCV coverage ( Fuji et al., 2021 ). Partly due to these reasons, a growing effort has developed for a multi-component approach as opposed to individual proteins in vaccine design ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Pneumococcal Surface Proteins as Virulence Factors, Immunogens, and Conserved Vaccine Targets

Aceil

Avci

2022

Front. Cell. Infect. Microbiol.

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Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths annually despite the availability of several multivalent pneumococcal conjugate vaccines (PCVs). Due to the limitations surrounding PCVs along with an evolutionary rise in antibiotic-resistant and unencapsulated strains, conserved immunogenic proteins as vaccine targets continue to be an important field of study for pneumococcal disease prevention. In this review, we provide an overview of multiple classes of conserved surface proteins that have been studied for their contribution to pneumococcal virulence. Furthermore, we discuss the immune responses observed in response to these proteins and their promise as vaccine targets.

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Section: Discussionmentioning

confidence: 99%