Comparison of spatula and cytobrush cytological techniques in early detection of oral malignant and premalignant lesions: a prospective and blinded study

Nanayakkara, P. G. Chandra L.; Dissanayaka, Waruna Lakmal; Nanayakkara, B. G.; Amaratunga, E. A. P. D.; Tilakaratne, W. M.

doi:10.1111/jop.12357

Cited by 15 publications

(21 citation statements)

References 21 publications

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“…The CB provided reliable sample quality, which is consistent with prior reports comparing spatulas, swabs, impression cytology, and lavage for various tissue sample collections for cytologic evaluation . Bristles provide a greater surface area for sample collection and the ability to more safely reach deeper portions of the lesion .…”

Section: Discussionsupporting

confidence: 81%

“…This is consistent with a pilot study where 40% of samples collected with the KS were nondiagnostic compared to the 37.5% in this study . The KS also produced the fewest number of multilayered samples, which is contradictory to a study where the KS technique resulted in more cell overlap than the CB . The KS is more expensive than either the CB or the SB and though reusable, must be flame sterilized or autoclaved between uses .…”

Section: Discussionmentioning

confidence: 70%

“…Multiple samples can be obtained with comparatively less risk of causing surface damage to the eye . Just as in this study with regard to identifying infectious organisms, a previous study comparing use of a metal spatula or CB for detection of oral neoplasia in human patients showed the superiority of the CB with fewer false‐negative samples …”

Section: Discussionmentioning

confidence: 70%

“…Brush cytology has been consistently shown to obtain a sufficient number of cells arranged in a monolayer promoting accurate analysis . This is now considered the technique of choice for conjunctival, oral mucosal, and cervical cytology in human and veterinary medicine …”

Section: Introductionmentioning

confidence: 99%

“…There are few reports of the use of corneal cytology in domestic species with most research focused on human reproductive and oral and ocular health . These diagnostic and screening strategies have been utilized in both specialized and nonspecialized veterinary practice for corneal lesions.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of 3 corneal cytology collection methods for evaluating equine ulcerative keratitis: Cytobrush, kimura platinum spatula, and handle edge of scalpel blade

Proietto

Beatty

Plummer

2018

Veterinary Ophthalmology

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of 3 corneal cytology collection methods for evaluating equine ulcerative keratitis: Cytobrush, kimura platinum spatula, and handle edge of scalpel blade

Proietto

Beatty

Plummer

2018

Veterinary Ophthalmology

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Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions

Walsh

Macey

Kerr

et al. 2021

Cochrane Database of Systematic Reviews

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BackgroundOral squamous cell carcinoma is the most common form of malignancy of the lip and oral cavity, often being proceeded by potentially malignant disorders (PMD). Early detection can reduce the malignant transformation of PMD and can improve the survival rate for oral cancer. The current standard of scalpel biopsy with histology is painful for patients and involves a delay whilst histology is completed; other tests are available that are unobtrusive and provide immediate results. ObjectivesPrimary objective: To estimate the diagnostic accuracy of index tests for the detection of oral cancer and PMD of the lip and oral cavity, in people presenting with clinically evident lesions.Secondary objective: To estimate the relative accuracy of the different index tests. Search methodsThe electronic databases were searched on 30 April 2013. We searched MEDLINE (OVID) (1946 to April 2013) and four other electronic databases (the Cochrane Diagnostic Test Accuracy Studies Register, the Cochrane Oral Health Group's Trials Register, EMBASE (OVID) and MEDION (Ovid)). There were no restrictions on language in the searches of the electronic databases. We conducted citation searches and screened reference lists of included studies for additional references. Selection criteriaWe selected studies that reported the diagnostic test accuracy of the following index tests when used as an adjunct to conventional oral examination in detecting PMD or oral squamous cell carcinoma of the lip or oral cavity: vital staining, oral cytology, light-based detection and oral spectroscopy, blood or saliva analysis (which test for the presence of biomarkers in blood or saliva). 1 Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions (Review)

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Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

Khowal

Naqvi

Monga

et al. 2018

J of Cellular Biochemistry

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The intriguing molecular pathways involved in oral carcinogenesis are still ambiguous. The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past 10 years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low 5-year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut, and/or alcohol, major etiologies. The expression modulations in the identified genes were analyzed in 16 patients comprising oral pre-cancer and cancer histo-pathologies. The genes SCCA1 and KRT1 were found to down regulate while DNAJC13, GIPC2, MRPL17, IG-Vreg, SSFA2, and UPF0415 upregulated in the oral pre-cancer and cancer pathologies, implicating the genes as crucial players in oral carcinogenesis.

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Comparison of spatula and cytobrush cytological techniques in early detection of oral malignant and premalignant lesions: a prospective and blinded study

Abstract: The cytobrush, unlike the spatula, is a useful screening instrument for early diagnosis of suspicious oral lesions and could therefore contribute to improved oral cancer prognosis.

Cited by 15 publications

References 21 publications

Comparison of 3 corneal cytology collection methods for evaluating equine ulcerative keratitis: Cytobrush, kimura platinum spatula, and handle edge of scalpel blade

Comparison of 3 corneal cytology collection methods for evaluating equine ulcerative keratitis: Cytobrush, kimura platinum spatula, and handle edge of scalpel blade

Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions

Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

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