Comparison of Skin Reactions to Extracts of House Dust, Mites, and Human Skin Scales

Spieksma, F. Th. M.; Voorhorst, R

doi:10.1111/j.1398-9995.1969.tb03762.x

Cited by 56 publications

(12 citation statements)

References 12 publications

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“…Increasing interest in storage mites has prompted several studies of the possible allergenic cross-reactivity between D. pteronyssinus, D. farinae and various storage mite species. Previous studies by Pepys et al [10] and Spieksma and Voorhorst [18], using skin-prick tests, indicated that there is a correlation between positive tests against D. pteronyssinus and D. farinae. Dasgupta and Cuncliffe [19] showed, by gel diffusion precipitin tests, that the two house dust mites have at least one and probably two antigens in common.…”

Section: Discussionmentioning

confidence: 91%

Lack of allergenic cross‐reactivity between storage mites and Dermatophagoides pteronyssinus

Hage‐Hamsten¹,

Johansson²,

Johansson³

et al. 1987

Clin Experimental Allergy

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Summary The allergenic cross‐reactivity between storage mites (Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiae and Acarus siro) and the house dust mite Dermatophagoides pteronyssinus was studied with the radio‐allergo‐sorbent test (RAST) and the RAST inhibition technique. RAST‐positive sera were obtained from fifty‐three farmers who were positive to at least one of the four storage mites. Sera from twelve of these farmers, eight of whom were also positive to D. pteronyssinus, were investigated with the RAST inhibition technique. No significant correlations were found between IgE‐antibody levels to any single storage mite and D. pteronyssinus. There was no correlation between the RAST results to A. siro and G. domesticus, whereas a significant correlation was found between L. destructor, G. domesticus and T. putrescentiae. The RAST inhibition studies confirmed the greater allergenic similarity between L. destructor, G, domesticus and T. putrescentiae than between A. siro and the other three storage mites. The results of our studies support the hypothesis that each of the storage mites and D. pteronyssinus possess their own unique allergen or allergens. Furthermore, L. destructor, G. domesticus and T. putrescentiae seem to be allergenically more closely related to each other than to A. siro.

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Section: Discussionmentioning

confidence: 91%

Lack of allergenic cross‐reactivity between storage mites and Dermatophagoides pteronyssinus

Hage‐Hamsten¹,

Johansson²,

Johansson³

et al. 1987

Clin Experimental Allergy

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“…It was fitting that these observations were made in the Netherlands since Van Leeuwenhoek had first described mites in 1693. In addition, to demonstrating that mites of the genus Dermatophagoides were the major source of allergens in house dust, Spieksma and Voorhorst also developed the technique for culturing these organisms . This in turn made it possible to manufacture dust mite extracts for commercial use and subsequently facilitated the purification of mite allergen .…”

Section: The Allergen Sourcesmentioning

confidence: 99%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

727

870

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The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

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“…It is well documented that allergy to house dust is one major cause of asthma and rhinitis [26,27], More over, several antigens and allergens in the house dust mite genus Dermatophagoides have been character ized and isolated [14][15][28][29]. Allergy to stored farming material caused by different genera of stor age mites also seems to be of importance [3][4][5][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Demonstration of Allergen Components in the Storage Mite <i>Lepidoglyphus destructor</i> by an Immunoblotting Technique

Johansson

Hage‐Hamsten²,

Johansson³

1988

Int Arch Allergy Immunol

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The allergen composition of crude extracts of the storage mite Lepidoglyphus destructor were investigated by sodium dodecylsulphate polyacrylamide gel electrophoresis and immunoblotting. The allergen components were detected by sera from allergic farmers with a positive radioallergosorbent test to L. destructor. The allergen-antibody complexes were visualized by rabbit anti-IgE and β-galactosidase-labelled sheep antirabbit IgG in a chromogenic substrate. Six out of the forty-three sera also had IgE antibodies to the culture medium, which were neutralized by addition of medium antigens before the demonstration of mite allergen components. A total of 11 allergen components were identified. Two of them were found to be major allergen components, identified by more than 50% of the 43 sera used in the study. These 2 IgE-binding components had molecular weights of approximately 18,000 and 16,000 daltons, respectively.

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Comparison of Skin Reactions to Extracts of House Dust, Mites, and Human Skin Scales

Cited by 56 publications

References 12 publications

Lack of allergenic cross‐reactivity between storage mites and Dermatophagoides pteronyssinus

Lack of allergenic cross‐reactivity between storage mites and Dermatophagoides pteronyssinus

EAACI Molecular Allergology User's Guide

Demonstration of Allergen Components in the Storage Mite <i>Lepidoglyphus destructor</i> by an Immunoblotting Technique

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