Comparison of Skin Antiseptic Agents and the Role of 0.01% Hypochlorous Acid

Abstract

Background Hypochlorous acid has both anti-microbial and wound healing properties with a growing role for use in pre-procedural care on the face. Objectives To compare the antiseptic property of 0.01% hypochlorous solution (HA), 5% povidone iodine (PI), 4% chlorhexidine (CHG) and 70% isopropyl alcohol (IPA) antiseptic on facial skin. Methods A prospective single-center clinical trial. Results A total of 21 participants were recruited. Bacterial growth was seen in CHG (10%), IPA (71%), PI (81%) and HA (95%) of specimens (p < 0.001). CHG had less growth when compared to HA (p = <0.001), IPA (p = <0.001) and PI (p = <0.001). No difference in bacterial growth was seen between HA and IPA (p = 0.063) or HA and PI (p = 0.25). Significant differences in mono-microbial and poly-microbial growth was seen between HA and IPA (p = 0.046) and HA and CHG (p= < 0.001). Staphylococcus epidermidis grew less frequently in CHG (10%), followed by IPA (29%), PI (71%) and HA (71%). Staphylococcus capitis grew less frequently in CHG (0%), followed by PI (14%), HA (24%) and IPA (29%). Conclusions CHG reduced the bacterial growth compared to HA, PI, and IPA. However, HA, PI and IPA had insignificant differences in bactericidal effects. Our study provides a supporting role of HA to be considered as an antiseptic.

The role of hypochlorous acid in the management of eye infections: a case series

“…HOCl 0.01% had an immediate microbicidal effect on all organisms evaluated compared with commonly used highly concentrated skin antiseptics (isopropyl alcohol 70%, povidone iodine 5%, chlorhexidine gluconate 4%). 5 , 14 This feature allows its use even in particularly sensitive and inflamed areas. In addition, the HOCl ophthalmic spray formulation was easy and comfortable to handle, thus promoting continuity of treatment as suggested by the presented clinical cases and previous literature evidence.…”

“…The HOCl ophthalmic spray is a medical device based on a 0.01% HOCl solution, the lowest pure HOCl concentration approved for the ocular surface. 14 Use of the HOCl ophthalmic spray is indicated as an adjuvant in treating blepharitis and for cleansing the periocular area in the days before or after ocular surgery. 15 , 16 Blepharitis is a common chronic ocular surface disease that involves 37–47% of patients referring to ophthalmologists and optometrists, causing significant discomfort and symptoms that include redness, itching, burning, foreign body sensations and blurred vision.…”

Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer

“…Remarkably, in addition to endogenous and environmental sources, skin HOCl exposure also occurs through application of topical disinfectants employed worldwide as clinical and consumer products (167)(168)(169)(170)(171). In human skin (as a function of concentration, pH, and exposure time), irritation and disruption of barrier function, alteration of the commensal microbiome, allergy, and contact hypersensitivity are expected outcomes of inappropriate topical HOCl product use not compliant with standard of care (Figure 5D) (142,143).…”

Kırmızı ve Kızılötesi Işığın Hipokloröz Asit Kombine Uygulamalarının ile Keratinosit (HaCaT) ve Fibroblast Hücre Hattı (Human Dermal Fibroblast HDFa) Üzerinde Etkilerinin Belirlenmesi

“…Hipokloröz asit, bakteri ve virüs gibi yabancı varlıkların istilasına yanıt olarak, bağışıklık sisteminin ayrılmaz bir parçası olan nötrofiller tarafından doğal olarak üretilmektedirler. Son 15 yılda Hipokloröz asit (HOCI) solüsyonları sitotoksisite olmaksızın hem antimikrobiyal hem de yara iyileştirici özellikler göstermiştir [12]. Yapılan araştırmalar, güçlü antimikrobiyal özellikleri, anti-enflamatuar etkileri ve biyofilmleri parçalama yeteneği nedeniyle HOCI solüsyonlarının yara ve skar yönetiminde potansiyel bir araç sunduğunu göstermektedir [13].…”