Comparison of sinusitis with and without allergic rhinitis: Characteristics of paranasal sinus effusion and mucosa

Suzuki, Masashi; Watanabe, Tetuo; Suko, Takeshi; Mogi, Goro

doi:10.1016/s0196-0709(99)90061-3

Cited by 38 publications

(25 citation statements)

References 17 publications

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“…Its putative biological role in the non-inflammatory condition of nasal mucosa remains unclear, whereas IL-8 is extremely upregulated in acute sinusitis. We found no difference in IL-8 protein concentration between polypous and non-polypous chronic rhinosinusitis [28].…”

Section: Discussioncontrasting

confidence: 71%

Chronic rhinosinusitis ? need for further classification?

Rudack

Sachse

Alberty

2004

Inflammation Research

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Section: Discussioncontrasting

confidence: 71%

Chronic rhinosinusitis ? need for further classification?

Rudack

Sachse

Alberty

2004

Inflammation Research

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“…Young adult patients have significantly higher levels than do older ones and in the case of IL-1ß, large nasal polyps contain higher levels [18]. Suzuki et al [4] made a comparison between allergic and nonallergic sinusitis. The analysis of the cytokines IL-1ß, -4, -5, -6 and -8 in sinus effusion showed a higher concentration of IL-5 in the group of patients with allergic chronic rhinosinusitis.…”

Section: Cytokine-related Chronic Rhinosinusitismentioning

confidence: 99%

“…The analysis of the cytokines IL-1ß, -4, -5, -6 and -8 in sinus effusion showed a higher concentration of IL-5 in the group of patients with allergic chronic rhinosinusitis. The presence of increased eosinophils and activated eosinophils in the paranasal sinus effusion and mucosae suggests that local IgE (type I reaction) plays a pivotal role in this type of chronic rhinosinusitis [4,28]. In vitro studies suggest an important role of IL-4 and IL-13 in allergic inflammation through the induction of immunoglobulin isotype switching to IgE in B lymphocytes.…”

Section: Cytokine-related Chronic Rhinosinusitismentioning

confidence: 99%

“…Clinical chronic rhinosinusitis (allergic vs. nonallergic) was defined in 1993/95 [2] and 1997 [3]. The etiology can be structured in allergic (induced by an IgE-mediated type I reaction) and nonallergic (endocrinopathy, anatomical disease, immunosuppression/deficiency and noxious inhaled substances) rhinosinusitis [4]. Macroscopically, visible polyps often accompany chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Chronic ‘Immunological’ Rhinosinusitis: General Aspects, Cytokines, Chemokines and Possible Therapeutic Consequences

Caversaccio

Uguccioni

Hartnell

et al. 2002

Otorhinolaryngol Nova

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Chronic rhinosinusitis is an inflammatory condition of the nose and the paranasal sinuses characterized by an infiltration of neutrophils, eosinophils in addition to lymphocytes (T), mast cells and macrophages. An international clinical definition of chronic rhinosinusitis exists, but not on an immunological basis. Chronic rhinosinusitis has different etiologies with consequently different immunological inflammatory mediator results. These inflammation mediators are responsible for propagating the inflammation. The complex interactions among these cells are mediated by a group of secreted low-molecular-weight proteins that are collectively designated as cytokines to denote their role in cell-to-cell communication. Cytokines assist in regulating the development of immune effector cells, act locally and some cytokines possess direct effector functions of their own. Higher levels of IL-1β, -3, -4, -5, -6, GM-CSF, IFN-γ, TNF-α and TGF-β have been reported in chronic rhinosinusitis compared to control tissues, but in the literature no concordant results have been found, possibly due to inhomogeneous groups. The attraction of leukocytes to tissues is essentially guided by chemokines (chemotactic cytokines). IL-8, MCP-3 and MCP-4, eotaxins 1 and 2 are increased, but as for the other cytokines no concordant results are diposable today.

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“…There is no question that there is a definite association of allergic rhinitis and CRS. 8,9 Suzuki et al 10 also showed an increase in activated eosinophils and neutrophils as well as Interleukin (IL)-5 in sinus effusions of allergic patients compared with non-allergic patients.…”

mentioning

confidence: 95%

A Descriptive Study of Diagnostic and Management Protocols in Chronic Rhinosinusitis

Varma¹,

Kumar²

2017

jemds

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BACKGROUNDRhinosinusitis is an inflammatory process involving the mucous membrane of the nose and one or more sinuses. The last decade has seen the development of a number of guidelines as well as publications on the epidemiology, diagnosis and treatment of rhinosinusitis and nasal polyposis in U.S.A. and Europe. In our country, proper population surveys are required to know the exact prevalence of chronic rhinosinusitis. However, even from the limited data available, it is very apparent that chronic rhinosinusitis is a significant health problem resulting in considerable medical costs and severe impact on the health related quality of life.This descriptive study was conducted to-1. To study the efficacy of clinical examination, diagnostic nasal endoscopy and CT scan in diagnosing chronic rhinosinusitis with and without polyps; 2. To study the surgical techniques and surgical findings of all the patients of chronic rhinosinusitis undergoing endoscopic sinus surgery; 3. Patient's satisfaction will be assessed by comparing preoperative and post-operative Rhinosinusitis Disability Index. MATERIALS AND METHODSOur study was a descriptive study conducted at our hospital for a time period of 1 year. The study consisted of 52 cases having clinically diagnosed as chronic rhinosinusitis according to symptoms defined by rhinosinusitis task force. RESULTSThere is a definitive male preponderance in our study with most of the patients coming from age groups between 20 -60 years. This is comparable to most of the studies. Chronic rhinosinusitis with polyps (42.4%), chronic rhinosinusitis without polyps (57.6%), ENT examination could identify 34.6% of patients with polyps, which includes three categories. Sinonasal polyposis (27.7%), Antrochoanal polyps (55.5%), Allergic fungal polyposis (15.6%). Postoperatively, patient's satisfaction is better in chronic rhinosinusitis without polyps. CONCLUSIONPatient's satisfaction was assessed by comparing pre-and post-operative Rhinosinusitis Disability Index. Highly significant difference was noted when pre-and post-operative Rhinosinusitis Disability Index (p= 0.003) were compared. For patients with polyps, P value= 0.00 and patients without polyps, P value= 0.00. KEYWORDSChronic Rhinosinusitis, Endoscopic Sinus Surgery, FESS, Allergic Rhinosinusitis. HOW TO CITE THIS ARTICLE: Varma BRV, Kumar GV. A descriptive study of diagnostic and management protocols in chronic rhinosinusitis. J. Evolution Med. Dent. Sci. 2017;6(61):4463-4469, DOI: 10.14260/Jemds/2017/965 BACKGROUND Chronic rhinosinusitis is quite a common disease of the nose and sinuses seen globally and in India. The incidence of rhinosinusitis is increasing in our country due to increasing air pollution, industrial fumes and allergic factors especially in the urban areas. In the rural areas also, rhinosinusitis is quite prevalent due to lack of proper hygiene and malnutrition resulting in low immunity.The last decade has seen the development of a number of guidelines, consensus documents as well as publications on the e...

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Comparison of sinusitis with and without allergic rhinitis: Characteristics of paranasal sinus effusion and mucosa

Cited by 38 publications

References 17 publications

Chronic rhinosinusitis ? need for further classification?

Chronic rhinosinusitis ? need for further classification?

Chronic ‘Immunological’ Rhinosinusitis: General Aspects, Cytokines, Chemokines and Possible Therapeutic Consequences

A Descriptive Study of Diagnostic and Management Protocols in Chronic Rhinosinusitis

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