Comparison of Single Dose Prophylactic Antibiotics Versus Five Days Antibiotic in Cesarean Section

Shah, Zeel; Kshirsagar, Nitin; Shah, Shikha

doi:10.14260/jemds/2014/2254

Cited by 4 publications

(9 citation statements)

References 17 publications

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“…11 A prospective randomized controlled study done by Zeel et al Showed that the average cost in the single dose group was significantly less then multiple dose group (p-value of 0.0001), which was in consistency with our results. 2 Our study observed a significant difference in bed occupancy and hospital stay in both the groups. On applying unpaired t test (1.9844) for the available data, pvalue obtained was (0.000000049<0.05%).…”

Section: Discussionmentioning

confidence: 44%

“…The duration in the single dose group was 8.4±3.3 days while in the multiple dose group was 8.1±2.9 days. 2 Our outcomes were in similarity with the studies done by Shaheen et al (OR=1), Prathima et al (p=0.45 and 0.83) and Ansari et al (p-value 0.50), we did not find any statistically significant difference in post-operative infection outcome of both the groups (Chi square value=0.1414, p=0.7068), thus we recommend the use of single dose regimen which is as effective as multiple drug regimen. [11][12][13] Limitations Our smaller sample size; wider study population is needed for significant results.…”

Section: Discussionmentioning

confidence: 99%

“…1 There is 5-20-fold greater risk of infection and infectious morbidity in women undergoing caesarean section as compared to vaginal delivery. [1][2][3] It is highly desirable to reduce the rates of surgical site infections (SSI) following caesarean section. As they are associated with significant morbidity and longer duration of hospital stay, which is troublesome in cases of re-admission for a woman trying to cope with both the postoperative period and new-born.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of oral versus parenteral antibiotics in cesarean section: an observational study

Bharadwaj¹,

Momaya²,

Kaushal³

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Women undergoing caesarean section are associated with high rates of post-operative infections, which causes significant rise in infectious morbidity, duration of hospital stay and cost treatment. Implementation of appropriate antibiotic prophylaxis is desirable to prevent these complications. We aimed to observe the outcome of Intravenous single dose antibiotic prophylaxis pre-operatively followed by oral antibiotics post-operatively, in comparison to other group with multiple dose Intravenous antibiotic prophylaxis post-operatively.Methods: An observational study conducted in the department of obstetrics and gynaecology, L.N.M.C and J.K. Hospital, Kolar Road, Bhopal, on patients undergoing Elective or Emergency Lower segment caesarean section (LSCS) for a period of 6 months, on 100 subjects, with 50 participants in each group. Null hypothesis was invalidated by statistically analysing the data using chi square test, Unpaired t-test and odds ratio.Results: Prevalence of c-section was more in 25-31year age group. Abnormal presentation was the most common indication for elective LSCS in both the groups (8%), non-progress of labour and foetal distress was the most common indication for emergency LSCS in group A and B respectively (10%). There was statistically insignificant difference in the occurrence of post-operative complications in both the groups (chi sq. value=0.4285, p value=0.5127) with overall, most common complication was febrile morbidity (8% vs.12%). Significant difference noted in total bed occupancy days (unpaired t-test 1.9844) (p-value.0.000000049<0.05%).Conclusions: We recommend the use of cost-effective single dose antibiotic prophylaxis in prevention of post-operative infectious morbidity in women undergoing caesarean section.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of oral versus parenteral antibiotics in cesarean section: an observational study

Bharadwaj¹,

Momaya²,

Kaushal³

2020

Int J Reprod Contracept Obstet Gynecol

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“…Similarly, in a study conducted by Z Shah et al all patients received antibiotics half hour before surgery and those in multiple doses received additional doses postoperatively. Accordingly, a considerable variation was observed in the timing of antibiotics [8]. In our study majority of subjects belong to the age group 22-25 and very few cases are from the age groups 18-21 and above 25.…”

Section: Discussionmentioning

confidence: 58%

Prophylactic Antibiotics in Caesarean Deliveries in a Teritiary Care Teaching Hospital

Gadde

Gogineni

Sri

et al. 2021

Int J Curr Pharm Sci

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Objective: Prophylactic antibiotics are used to prevent post-operative infections after Caesarean Section. Studies have suggested a significant role in the timing of prophylaxis. The aim of the study was to evaluate the pattern of antibiotics used and to identify the frequency of post-operative infections in patients undergoing Caesarean Section. Methods: A prospective observational study was carried out for 6 mo. A total of 120 patients who met the inclusion criteria were recruited into the study. Data collection form was prepared using NICE guidelines. A total of 120 medical records were analysed. Results: The results revealed that out of 120 study subjects, prophylactic antibiotics Cefotaxime, Metronidazole and Cefixime were used in 119 (99.17%). Conclusion: This study concludes that giving prophylactic antibiotics before skin incision reduces risk of post-operative infections in women undergoing Caesarean Section. As the patients did not produce any infections post-surgery 3rd generation Cephalosporins along with Nitro-imidazoles can be considered as an effective prophylactic therapy for use during caesarean sections.

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“…13 Another similar study conducted by Shah et al, concluded that there was no statistically significance in the rate of infections in both the groups. 14 Lyimo et al, conducted a similar study which showed the incidence of surgical site infection (12/250) 4.8% in single dose when compared to 16 /250 (6.4%) in multiple doses group. 15 In a study by Westen et al, in the single dose group (n-89) six women (6.7%) developed a wound infection compared with nine (10.3%) in multi-dose (n-87), which was non-significant.…”

Section: Discussionmentioning

confidence: 95%

Comparison of single dose versus multiple doses of antibiotic prophylaxis in elective caesarean section

Mishra

2022

Int J Reprod Contracept Obstet Gynecol

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Background: Infectious complications after caesarean delivery (CD) are a substantial cause of maternal morbidity, increase in hospital stay and treatment cost. The spectrum of these complications’ spreads from fever, wound infection, endometritis, urinary tract infection, and some serious complications like pelvic abscess, septic shock and septic pelvic vein thrombophlebitis. To prevent these prophylactic antibiotics have been used however the use of antibiotics should be judicious. Aim was to compare the efficacy of single dose versus multiple doses of antibiotics in elective caesarean section.Methods: This study was conducted in a tertiary care hospital from December 2017 to May 2020. It was a prospective case control study. Sample size was 600, patients were randomly allocated in two groups A and B by card method. Pregnancy category B drug “cefuroxime” was given.Results: Incidence of SSI was 2.7% (n=8) in single dose group and 3% (n=9) in multi-dose group, this difference was not statistically significant. Incidence of fever for more than 48 hours was 1.3% (n=4) in the single dose group and 0.6% (n=2) in multi-dose group, this difference was not statistically significant. Urine R/M for all patients on 3rd post-operative day, in single dose group 2.3% (n=7) patients and in multi-dose group 2.0 % (n=6) patients had more than 5 pus cells. Patients, who had more than 5 pus cells in urine R/M, were subjected to urine culture and sensitivity. Four (1.40%) patients in single dose group had positive cultures (E. coli was detected in three patients and Klebsiella pneumoniae in one) and three (1.0%) patients, in multi dose group, (all the three patients had E. coli in growth). These results were statistically not significant.Conclusions: Single dose antibiotic prophylaxis was found to be comparable to multi-dose antibiotics in our study. Hence it is advocated that single dose antibiotic can be given in elective caesarean section as it is cost effective and as efficient as multi-dose regimen, ensures complete compliance and minimizes side effects and cut-down nursing work-load.

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Comparison of Single Dose Prophylactic Antibiotics Versus Five Days Antibiotic in Cesarean Section

Cited by 4 publications

References 17 publications

Effectiveness of oral versus parenteral antibiotics in cesarean section: an observational study

Effectiveness of oral versus parenteral antibiotics in cesarean section: an observational study

Prophylactic Antibiotics in Caesarean Deliveries in a Teritiary Care Teaching Hospital

Comparison of single dose versus multiple doses of antibiotic prophylaxis in elective caesarean section

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