Comparison of several blood lipid-related indexes in the screening of non-alcoholic fatty liver disease in women: a cross-sectional study in the Pearl River Delta region of southern China

Wang, Jian; Su, Zhenzhen; Feng, Yi-Jin; Xi, Ruihan; Liu, Shiyuan; Wang, Peixi

doi:10.1186/s12876-021-02072-1

Cited by 16 publications

(21 citation statements)

References 59 publications

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“…The ROC analyses also showed that there was a significantly better ability of CMI for identifying MAFLD among female, young and nonobese subjects. Similar to our findings, a cross-sectional study in the Pearl River Delta region of southern China found that CMI was a recommended indicator for screening women for nonalcoholic fatty liver disease (NAFLD) and could be used to detect high-risk NAFLD (44). As the metabolism, body composition, and coexisting diseases changed with aging (45-47), and the higher excessive fat accumulation of young people caused by dietary irregularities and insufficient exercise, it was reasonable that the performance of CMI may be influenced by age (48).…”

Section: Discussionsupporting

confidence: 88%

Cardiometabolic index: A new predictor for metabolic associated fatty liver disease in Chinese adults

Duan

Yang²,

Xia³

et al. 2022

Front. Endocrinol.

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Objective: Cardiometabolic index (CMI) is a well promising indicator for predicting obesity-related diseases, but its predictive value for metabolic associated fatty liver disease (MAFLD) is unclear. This study aimed to investigate the relationship between CMI and MAFLD and to evaluate the predictive value of CMI for MAFLD.Methods: A total of 943 subjects were enrolled in this cross-sectional study. CMI was calculated by multiplying the ratio of triglycerides and high-density lipoprotein cholesterol (TG/HDL-C) by waist-to-height ratio (WHtR). Multivariate logistic regression analysis was used to systematically evaluate the relationship between CMI and MAFLD. Receiver operating characteristic (ROC) curves were used to assess the predictive power of CMI for MAFLD and to determine the optimal cutoff value. The diagnostic performance of high CMI for MAFLD was validated in 131 subjects with magnetic resonance imaging diagnosis.Results: Subjects with higher CMI exhibited a significantly increased risk of MAFLD. The odds ratio for a 1-standard-deviation increase in CMI was 3.180 (2.102-4.809) after adjusting for various confounding factors. Further subgroup analysis showed that there were significant additive interactions between CMI and MAFLD risk in gender, age, and BMI (P for interaction < 0.05), and the area under the ROC curve(AUC) of CMI for predicting MAFLD were significantly higher in female, young, and nonobese subgroups than that in male, middle-aged and elderly, and obese subgroups (all P < 0.05). Moreover, among nonobese subjects, the AUC of CMI was significantly higher than that of waist circumference, BMI, TG/HDL-C, and TG (all P < 0.05). The best cutoff values of CMI to diagnose MAFLD in males and females were 0.6085 and 0.4319, respectively, and the accuracy, sensitivity, and specificity of high CMI for diagnosing MAFLD in the validation set were 85.5%, 87.5%, and 80%, respectively.Conclusions: CMI was strongly and positively associated with the risk of MAFLD and can be a reference predictor for MAFLD. High CMI had excellent diagnostic Frontiers in Endocrinology frontiersin.org 01

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Section: Discussionsupporting

confidence: 88%

Cardiometabolic index: A new predictor for metabolic associated fatty liver disease in Chinese adults

Duan

Yang²,

Xia³

et al. 2022

Front. Endocrinol.

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“…The comprehensive computer literature search from PubMed, MEDLINE, Web of Science, EMBASE and the Cochrane Library revealed 4722 articles, as shown in Figure 1 . Ultimately, 20 studies involving 165,725 participants were included [ 10 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

The Diagnostic and Prognostic Value of the Triglyceride-Glucose Index in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Systematic Review and Meta-Analysis

et al. 2022

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Metabolic dysfunction-associated fatty liver disease (MAFLD) has been related to a series of harmful health consequences. The triglyceride-glucose index (TyG index) appears to be associated with MAFLD. However, no consistent conclusions about the TyG index and incident MAFLD have been reached. PubMed, MEDLINE, Web of Science, EMBASE and the Cochrane Library were searched. Sensitivities, specificities and the area under the receiver operating characteristic (AUC) with a random-effects model were used to assess the diagnostic performance of the TyG index in NAFLD/MAFLD participants. Potential threshold effects and publication bias were evaluated by Spearman’s correlation and Deeks’ asymmetry test, respectively. A total of 20 studies with 165725 MAFLD participants were included. The summary receiver operator characteristic (SROC) curve showed that the sensitivity, specificity and AUC were 0.73 (0.69–0.76), 0.67 (0.65, 0.70) and 0.75 (0.71–0.79), respectively. Threshold effects (r = 0.490, p < 0.05) were confirmed to exist. Subgroup analyses and meta-regression showed that some factors including country, number of samples, age and disease situation were the sources of heterogeneity (p < 0.05). Our meta-analysis suggests that the TyG index can diagnose and predict MAFLD patients with good accuracy. The number of studies remains limited, and prospective studies are needed.

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“… 9 , 14–16 Meanwhile, studies have demonstrated that the TyG index changes with the development of MAFLD. 11 , 17 , 18 However, most of these studies are cross-sectional. Therefore, we designed this cohort study to investigate the longitudinal association of baseline TyG index with the risk of incident MAFLD in the Chinese.…”

Section: Introductionmentioning

confidence: 99%

Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Cohort Study

Zhang¹,

Guan²,

Zhang³

et al. 2022

DMSO

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Objective Insulin resistance (IR) is a major factor involved in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). Triglyceride-glucose (TyG) index, an easily detected surrogate marker of IR, has not been explored sufficiently on its relationship with incident MAFLD risk. This study sought to investigate the association of baseline TyG index with the risk of MAFLD in a Chinese cohort. Methods This health check-up cohort was constructed with eligible 2056 Chinese from a community. The TyG index was calculated as ln (fasting triglyceride [mg/dL]×fasting glucose [mg/dL]/2). Cox proportion hazard models were used to evaluate the longitudinal association between baseline TyG index and the risk of MAFLD. Results During an average follow-up of 2.5 ± 0.5 years, about 12.8% of the subjects developed MAFLD, and the incidence of MAFLD trended to increase with the quartile TyG index ( P trend < 0.05). After adjusting for all confounders, TyG index was independently correlated with the risk of incident MAFLD (HR = 1.784, 95% CI = 1.383–2.302, P < 0.001), and the risk of MAFLD in the highest quartile of TyG index was two times higher than that in the lowest quartile (95% CI = 1.377–2.992, P = 0.001). The restricted cubic spline analysis showed that the relationship between TyG index and the risk of MAFLD was linear in males ( P for total < 0.001; P for non-linearity = 0.746), but nonlinear in females ( P for non-linearity = 0.040). Conclusion A high baseline TyG index was independently associated with a high risk of incident MAFLD, and we might develop the strategy of MAFLD prevention based on the TyG index.

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Comparison of several blood lipid-related indexes in the screening of non-alcoholic fatty liver disease in women: a cross-sectional study in the Pearl River Delta region of southern China

Cited by 16 publications

References 59 publications

Cardiometabolic index: A new predictor for metabolic associated fatty liver disease in Chinese adults

Cardiometabolic index: A new predictor for metabolic associated fatty liver disease in Chinese adults

The Diagnostic and Prognostic Value of the Triglyceride-Glucose Index in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Systematic Review and Meta-Analysis

Association Between Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: A Cohort Study

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