Comparison of Serum Zinc Level Between Neonates With Jaundice and Healthy Neonates

Boskabadi, Hassan; Maamouri, Gholamali; Zadeh, Hossein Mohsen; Shakeri, Mohammad Taghi; Ghayour‐Mobarhan, Majid; Mohammadi, Shabnam; Ferns, Gordon A.

doi:10.17795/semj27392

Cited by 11 publications

(18 citation statements)

References 12 publications

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“…Some studies showed that higher levels of Zn had protective effects against hyperbilirubinemia and this in agreement with our results that Zn supplementation was associated with decreased in serum bilirubin [16].…”

Section: Discussionsupporting

confidence: 93%

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

Elfarargy¹,

Ashmawy

Abu-Risha

et al. 2020

Preprint

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Background: Neonatal jaundice is a common neonatal disease which had adverse effect in the neonates especially preterm neonates when the level of indirect bilirubin is high enough to pass the blood brain barrier causing bilirubin encephalopathy or kernicterus. Aim: The aim of this study is to investigate the value of zinc (Zn) supplementation in preterm neonates with jaundice and if it will be beneficial or not. Patients and methods: A prospective randomized clinical trial (RCT) study, identification number is TCTR20200504007, which was done at Tanta University Hospital (TUH) from July 2016 to March 2018 on 200 preterm neonates suffering from neonatal jaundice. The studied neonates were divided into 2 groups: group 1, which received Zn and phototherapy, and group 2, which received phototherapy only and did not take Zn. In the group 1, 100 preterm neonates with jaundice received Zn as 0.6 ml(cm3) of zinc origin/kg/day orally through oro/nasogastric tube divided into 2 doses (/12 hours) which is equal 1.2 mg elemental zinc/kg/day orally for 10 day. Results: There was no significant difference in serum bilirubin between the 2 groups in the 2nd, 4th and 6th day of admission while the serum bilirubin was significantly decreased in neonates who were treated by Zn and phototherapy in group 1, compared with neonates of group 2 who were treated with phototherapy only in the 8th , 9th and 10th day of admission where the p value was 0.045* ,0.027* and 0.004* respectively. Conclusion: Zn administration in jaundiced preterm neonates is beneficial in decreasing serum bilirubin. Recommendation: Zn supplementation for jaundiced preterm neonates.

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Section: Discussionsupporting

confidence: 93%

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

Elfarargy¹,

Ashmawy

Abu-Risha

et al. 2020

Preprint

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“…[13] With respect to demographic data of studied groups, the percentage of males was 56 percent higher than 44 percent of females, the male to female ratio in cases was 1.2:1. This in agreement with Boskabadi et al [3] who reported that male to female ratio was (1.2:1) and Hasan [4] who reported that male to female ratio was (1.3:1) with male predominance. In fact, male newborns are always more susceptible to neonatal jaundice, although the cause remains unknown.…”

Section: Discussionsupporting

confidence: 92%

“…In fact, male newborns are always more susceptible to neonatal jaundice, although the cause remains unknown. [14] The control mean age was 6.371.75 days that was comparable to the study of Boskabadi et al [3] who showed that the mean age 6.75 ± 4.88 days in the control group. In addition, the mean gestational age in cases was 38.15 ± 1.19 week and in control group was 38.13± 1.11 week that was comparable to the study of Tan et al [15] who reported GA of 38.48±1.…”

Section: Discussionsupporting

confidence: 81%

“…Certain therapies to avoid bilirubin neurotoxicity by reducing the level of unconjugated bilirubin by enterohepatic circulation inhibition are available. [3] Zinc is one of the critical trace elements for normal function and is therefore associated with tragic deficiencies when deficient. [4] Zinc plays a vital role in a wide range of biological activities, including nucleic acid metabolism, immune function by serving as a cofactor in the development of more than 200 enzymes, e.g.…”

Section: Introductionmentioning

confidence: 99%

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serum zinc level in neonates with indirect hyperbilirubinemia

Ali¹,

Abdel-Aal

Elsamanoudy

et al. 2019

International Journal of Medical Arts

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Background: The most common cause of hospital admission in the first month of life is the neonatal jaundice. Some factors [e.g., prenatal, neonatal factors, maternal factors, and environmental factors (such as zinc) influence the frequency of neonatal jaundice. In terms of neonates, it is proposed that there is a correlation between serum zinc quality and hyperbilirubinemia. Aim of the work: To evaluate the level of serum zinc in term neonates with indirect hyperbilirubinemia. Patients and methods: A case control study carried out at the neonatal intensive care unit (NICU) and pediatric outpatient clinic of New Damietta, Al-Azhar University Hospital, from June 2018 to February 2019. It included 75 neonates with neonatal jaundice as cases group and 75 healthy neonates of matched age and sex as a control group. All were assessed clinically and serum zinc levels were determined and documented. Results: Level of serum zinc in neonates with non-hemolytic hyperbilirubinemia (103.3±36.56 ug/dl) was significantly lower than healthy neonates without jaundice (128.62 ± 40.83 ug/dl) and zinc deficiency in jaundiced neonates (25.3%) was statistically significant more than healthy neonates)6.7%). There was no significant relation between the level of serum zinc and other factors like the maternal age, parity, pattern of feeding, gender and weight, but there was significant correlation with maternal zinc intake during pregnancy. Conclusion: We concluded that serum zinc level in term neonates with neonatal jaundice was statistically significant decreased than healthy term neonates.

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“…16 The present study confirmed the findings of other recent studies that have reported the reduction of serum Zn level in icteric infants, when the serum bilirubin increased more likely due to competitive effect. 17,18 In this study the mean serum Zn level in newborns at admission (before EXT) was 48.53±4.94 μg/dl that was at a level lower than normal range in healthy newborns (50-100 μg/dl).…”

Section: Discussionmentioning

confidence: 50%

Study of changes in the blood levels of copper and zinc following the blood exchange transfusion in neonates with hyperbilirubinemia

et al. 2016

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Background: Blood exchange transfusion (EXT) is an essential treatment method in some icteric newborns and causes some changes in trace elements in them. The effects of blood exchange transfusion on zinc (Zn) and copper (Cu) in newborn infants is unknown. This study was conducted to determine the possible effects of EXT on Zn and Cu by comparing the levels of Zn and Cu in jaundiced neonates.Methods: In this study, 30 jaundiced term neonates undergoing EXT for the first time, because of idiopathic unconjugated hyperbilirubinemia, were selected. The Zn and Cu levels of 30 blood bank donors’ samples used for EXT were measured and 30 pairs of umbilical cord blood samples were examined for Zn and Cu before and one hour and five days after exchange transfusion. The serum bilirubin concentration was measured before and after EXT. The collected data in laboratory were analysed by statistical methods using SPSS.19. Results: In this study 43% were girls and 56.7% were boys and the average age of the infants was 4.56 days at the time of admission. Before EXT, the average of serum bilirubin was 27.74±2.03 mg/dl, and the average of serum Zn was 48.53±4.94 μg/dl that was lower than serum Zn concentration one hour after EXT (55.98±7.60 μg/dl) and five days after EXT (56.63±10.92 μg/dl). This difference was statistically significant (P=0.001). Furthermore, the average of serum Cu concentration was 59.56±10.92 μg/dl before EXT, 60.48±10.05 μg/dl after EXT and 58.64±8.06 μg/dl five days after EXT that didn't vary significantly from each other.Conclusions: The results showed that after EXT, the serum Zn concentration was higher than before EXT but the changes in serum Cu concentration was little and negligible.

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Comparison of Serum Zinc Level Between Neonates With Jaundice and Healthy Neonates

Cited by 11 publications

References 12 publications

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

WITHDRAWN: Zinc Supplementation in Preterm Neonates with Jaundice: Is It Beneficial?

serum zinc level in neonates with indirect hyperbilirubinemia

Study of changes in the blood levels of copper and zinc following the blood exchange transfusion in neonates with hyperbilirubinemia

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