Comparison of serum prostate-specific antigen levels and PSA density in african-american, white, and hispanic men without prostate cancer

Abdalla, Ibrahim; Ray, Paul S.; Ray, Vera; Vaida, Florin; Vijayakumar, Srinivasan

doi:10.1016/s0090-4295(97)00617-1

Cited by 38 publications

(19 citation statements)

References 32 publications

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“…37 Indeed, results from the Flint Men's Health Study found greater prostate volume significantly associated with blood IGFBP3 levels independent of age and BMI. 38 As in prior studies, PSA levels, [4][5][6][7][39][40][41] but not %fPSA, 6,34,41 were significantly lower among CA than AA men. PSA responds to androgen stimulation, and androgen levels are inversely correlated with body adipose mass.…”

Section: Discussionsupporting

confidence: 64%

“…3 Indeed, PSA levels may be affected by many factors unrelated to prostate disease, including age and race. [4][5][6][7] Several recent studies also report that PSA levels are approximately 0.2-0.4 ng/mL lower among otherwise healthy but obese men. [8][9][10] However, PSA was not associated with body mass index (BMI) in other clinical populations, [11][12][13][14] and the relevance of BMI to the interpretation of PSA levels as a cancer screening test remains unclear.…”

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confidence: 96%

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Effects of obesity and height on prostate‐specific antigen (PSA) and percentage of free PSA levels among African‐American and Caucasian men

Fowke

Signorello

Chang

et al. 2006

Cancer

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BACKGROUND.Prior studies suggest that obese men have lower prostate‐specific antigen (PSA) levels than leaner men. Caucasian (CA) men also may have lower PSA levels than African‐American (AA) men, but the relevance of body size to racial disparities in PSA levels is unclear. The association between body mass index (BMI) and height on PSA and percentage of free PSA (%fPSA) was investigated within AA and CA men without a prior prostate cancer diagnosis.METHODS.AA (n = 150) and CA (n = 149) men of similar socioeconomic status completed an extensive in‐person interview and donated blood. PSA and %fPSA levels were compared across race, BMI, and height categories after adjusting for age and other factors.RESULTS.PSA levels decreased with increasing BMI (PSA = .72, .69, .67, .59 ng/mL for BMI 18.5 to <25, 25 to <30, 30 to <35, and ≥35, respectively; Ptrend = .18), and trends were significant among men less than age 60 years (PSA = .81, .76, .66, .59, respectively; Ptrend = .02). fPSA also significantly decreased with BMI among men <60 years (Ptrend = .04). In contrast, %fPSA was not associated with BMI. However, %fPSA increased 27% across height categories (Ptrend = .02). PSA levels were significantly lower among CA men (PSAAA = 0.87, PSACA = 0.63 ng/mL; P < .01), whereas %fPSA levels did not differ by race. Also, associations between body size and PSA or %fPSA did not significantly differ by race, and adjustment for BMI and height had no effect on the racial disparity in PSA (PSAAA = 0.87, PSACA = 0.63 ng/mL; P < .01).CONCLUSIONS.The data suggest that race, BMI, and height are independently associated with PSA and %fPSA levels. Cancer 2006. © 2006 American Cancer Society.

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Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 96%

Effects of obesity and height on prostate‐specific antigen (PSA) and percentage of free PSA levels among African‐American and Caucasian men

Fowke

Signorello

Chang

et al. 2006

Cancer

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“…Literature has called the attention to several risks for developing prostate cancer, with race being one of them (10,11). Studies conducted in NorthAmerican population showed a high incidence of prostate cancer in Blacks, with a low incidence in Whites (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of prostate adenocarcinoma according to race in an university hospital

et al. 2003

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Objectives: To determine the prevalence of prostate cancer and to assess potential associations between race and prostate adenocarcinoma according to age in patients followed in an outpatient service of general urology in an university hospital.Materials and Methods: Retrospective study of men aged from 40 to 79 years, followed during the period from 1999 to 2001. Patients were classified according to race in White, Mulatto and Black. Those with abnormal digital rectal examination and/or serum level of prostate specific antigen (PSA) > 4.0 ng/ml, underwent a transrectal prostate biopsy.Results: 580 patients with mean age of 60.7 ± 10.0 years were studied, with 116 Whites (20.0%), 276 Mulattos (47.6%) and 188 Blacks (32.4%). There was no significant difference regarding the mean age (p = 0.62), serum level of PSA (p = 0.65) and prevalence of prostate adenocarcinoma between Whites, Mulattos and Blacks (p = 0.36). While studying the association between race classified in 2 groups (Whites versus Mulattos and Blacks) and prostate adenocarcinoma according to age, no association was found when the total group was assessed, neither among those with age above 60 years old. In the group between 40 and 60 years, even though without statistical significance, the estimate of prevalence ratio was 2.2 (CI 95%: 0.52 to 9.0; p = 0.38).Conclusion: Prostate adenocarcinoma was found in 16.6% of the patients aged between 40 and 79 years. We did not find a racial influence in our population.

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“…35 Conversely, in another study they did ®nd that African-American men without prostate cancer had higher PSA and PSA density than whites or Hispanics after adjustment for age and prostate volume. 36 In a follow-up study of the same cohort, race was not an independent predictor of PSA in multivariable analysis and they concluded that PSA differences are due to sociological rather than biological causes. 37 In a multicenter registration study of the Radiation Therapy Oncology Group (RTOG), they also found that African-American men with nonmetastatic prostate cancer had higher PSA than whites and that household income, education and insurance alone or in combination did not completely account for this racial difference.…”

Section: Psa In Black Menmentioning

confidence: 98%

Targeted screening for prostate cancer in African-American men

2000

Prostate Cancer Prostatic Dis

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Comparison of serum prostate-specific antigen levels and PSA density in african-american, white, and hispanic men without prostate cancer

Cited by 38 publications

References 32 publications

Effects of obesity and height on prostate‐specific antigen (PSA) and percentage of free PSA levels among African‐American and Caucasian men

Effects of obesity and height on prostate‐specific antigen (PSA) and percentage of free PSA levels among African‐American and Caucasian men

Prevalence of prostate adenocarcinoma according to race in an university hospital

Targeted screening for prostate cancer in African-American men

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