Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer

Sun, Mingzhong; Song, Jiangxiang; Zhou, Zhongwei; Zhu, Rong; Jin, Hao; Ji, Yuqiao; Lü, Qiang; Ju, Huixiang

doi:10.1155/2016/3823121

Cited by 23 publications

(21 citation statements)

References 32 publications

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“…CEA is an antigen in cancer tissues. As the most widely used tumor marker, CEA is highly expressed in a variety of cancer tissues (colon, stomach, liver and lung cancer) ( 19 ). NSE, a neuron and neuroendocrine cell-specific enzyme, is highly specific for liver cancer tissue.…”

Section: Discussionmentioning

confidence: 99%

Effects of different methods of anesthesia and analgesia on immune function and serum tumor marker levels in critically ill patients

Song

Dong

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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This study investigated the effects of different anesthesia and analgesia methods on immune function and serum tumor marker levels of critically ill patients undergoing tumor resection surgery. Seventy-six critically ill patients with indications for tumor resection surgery were selected in The Second Affiliated Hospital of Zhengzhou University from September 2015 to August 2016. The patients were randomly divided into a control and an observation group (38 patients each). The patients in the control group were treated with general anesthesia and postoperative intravenous analgesia, while the patients in the observation group were treated with general anesthesia and epidural anesthesia and postoperative epidural analgesia. Venous blood samples were collected at 30 min before anesthesia (T1), 2 h after the beginning of the surgery (T2), immediately after surgery (T3), 24 h after surgery (T4) and 72 h after surgery (T5). The viable cell percentage of T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and natural killer (NK) cells were measured by flow cytometry. The levels of carcinoembryonic antigen, sugar chain antigen 199, sugar chain antigen 125, neuron specific enolase and cytokeratin 19 were detected by electrochemiluminescence at 24 h before and after operation. Our results showed the levels of CD3+, CD4+ and CD4+/CD8+ in the control group at T3-T5 were significantly lower than those at T1 (p<0.05). The CD3+ level in observation group at T3 was also significantly lower than the level at T1 (p<0.05), but it increased at T4 and T5 and showed no significant difference compared with the initial level (p>0.05). The levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group at T2-T5 (p<0.05). And, the levels of CD3+ and CD4+ were significantly higher than those in the control group at T4 (p<0.05). The level of CD4+/CD8+ was significantly higher than that in the control group at T5 (p<0.05). No significant differences were found in the levels of CD8+ and NK cells between the 2 groups at any of the time-points (p>0.05). No significant differences were found either in any of the tested tumor markers in either group after 24 h. Even without differences on the tumor marker levels, these results suggest that general anesthesia combined with epidural anesthesia and analgesia produces milder deleterious effects on the immune function of perioperative critically ill patients than general anesthesia combined with intravenous analgesia.

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Section: Discussionmentioning

confidence: 99%

Effects of different methods of anesthesia and analgesia on immune function and serum tumor marker levels in critically ill patients

Song

Dong

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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“…The limited sensitivity and specificity of the usual biomarkers for early staging of NSCLC as carcinoembryonic antigen (CEA) is the main reason to search for another alternative diagnostic and predictive markers for NSCLC, so that a number of deregulated lncRNA was proposed as a hallmark feature in human cancer .…”

Section: Introductionmentioning

confidence: 99%

Circulating long non‐coding RNA GAS5 and SOX2OT as potential biomarkers for diagnosis and prognosis of non‐small cell lung cancer

Kamel

Atef

Mackawy

et al. 2019

Biotech and App Biochem

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Early diagnosis of non-small cell lung cancer (NSCLC) is essential for patient treatment and prognosis. Long noncoding RNA (lncRNA) have potential roles in tumor initiation and differentiation. The objective of this study was to investigate whether the circulating lncRNA, growth arrest-specific transcript 5 (GAS5) and SOX2 overlapping transcript (SOX2OT), could be used as noninvasive biomarkers for NSCLC diagnosis. Moreover, we aimed at evaluating the association between lncRNA and the clinicopathological features of NSCLC in order to predict the cancer prognosis. The results showed significant downregulation of GAS5 expression and upregulation of SOX2OT in NSCLC patients compared with controls (P < 0.001). Furthermore, the expression level of GAS5 was declined in stage IV of NSCLC, but SOX2OT expression was increased sharply in stages III and IV. The expression levels of lncRNAs were used to distinguish NSCLC patients from control with an area under curve of 0.81 (sensitivity 82.5% and specificity 80%) for GAS5 and 0.73 (sensitivity 76.3% and specificity 78.6%) for SOX2OT. The combination of GAS5 and SOX2OT showed differentiation NSCLC patients from controls with increased sensitivity (83.8) and specificity (81.4). In conclusion, the newly developed diagnostic panel involving of circulating GAS5 and SOX2OT could be perfect biomarker for diagnosis and prognosis of

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“…The traditional lung cancer biomarkers remain the most studied biomarkers for lung cancer, especially in developing countries [ 7 ], which show an increased rate of positivity as the cancer stage advances, but could hardly be serve as standalone indicators of disease at its earliest stages. For example, the most sensitive Cyfra21-1 alone had a reported sensitivity threshold of 44% [ 8 , 9 ], and the most sensitive early diagnosis of lung cancer methodology with a biomarker panel remains to be determined, though preliminary analysis suggest a relevant sensitivity threshold of > 60% [ 10 , 11 ]. Therefore, new serologic biomarkers with sufficient sensitivity to reliably diagnose asymptomatic patients with lung cancer should be investigated.…”

Section: Introductionmentioning

confidence: 99%

A novel serum based biomarker panel has complementary ability to preclude presence of early lung cancer for low dose CT (LDCT)

Wang¹,

Zhi

Yang

et al. 2017

Oncotarget

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Low Dosage Computerized Tomography (LDCT) has been shown to improve early detection of lung cancer and mortality rates in high-risk individuals, which was, however, limited by specifically coverage for heavy smokers and high rates of false positivity. Here, we aim to investigate a novel biomarker for early detection of lung cancer, and further extend to concentrate high-risk subjects for increasing specificity and coverage of LDCT. We performed retrospective blinded evaluation of lung cancer and healthy controls in training and validation cohorts. Macrophage inhibitory cytokine 1 (MIC-1) alone and panel were assessed. Our data showed the sensitivity of MIC-1 was 72.2% and 67.1% for lung cancer diagnosis and early diagnosis respectively, at 96.6% specificity, which were significantly higher than Cyfra21-1, NSE CA125, CEA and SCC. At 90% specificity, the panel of MIC-1, Cyfra21-1, CA125 and CEA provided 89.5% sensitivity for early diagnosis of lung cancer, which could be used to concentrate the high-risk subjects for further LDCT screening. We conclude that MIC-1 have great capacity in early lung cancer diagnosis. The algorithmic panel of MIC-1, Cyfra21-1, CA125 and CEA could be used to refine the preselection criteria of high-risk subjects, and thus might facilitate the widespread implementation of LDCT screening.

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Comparison of Serum MicroRNA21 and Tumor Markers in Diagnosis of Early Non-Small Cell Lung Cancer

Cited by 23 publications

References 32 publications

Effects of different methods of anesthesia and analgesia on immune function and serum tumor marker levels in critically ill patients

Effects of different methods of anesthesia and analgesia on immune function and serum tumor marker levels in critically ill patients

Circulating long non‐coding RNA GAS5 and SOX2OT as potential biomarkers for diagnosis and prognosis of non‐small cell lung cancer

A novel serum based biomarker panel has complementary ability to preclude presence of early lung cancer for low dose CT (LDCT)

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