Comparison of Serum Brain-Derived Neurotrophic Factor Levels in Diabetic Patients With and Without Retinopathy

Rashid, Romana R; Fazal, Ayesha; Khan, Qudsia Umaira; Qamar, Misbah Ul; Ahmed, Farooq; Laique, Talha

doi:10.7759/cureus.12028

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…In this context, it appears that BDNF may exert a general hypoglycemic effect by coordinating insulin and glucagon release. Coherently with this notion, it is becoming increasingly clear that BDNF signaling may participate in the development of type 2 diabetes mellitus (T2DM) [ 79 , 80 , 81 ]: specifically, BDNF levels were found to be decreased in patients with T2DM, and a negative correlation between insulin sensitivity and BDNF plasma concentration was also observed [ 82 , 83 ]. Interestingly, similar effects were also noted in rodent experimental models, where BDNF was shown to restore the alterations in pancreatic insulin and glucagon content in obese diabetic mice.…”

Section: Neurotrophins: From Cell Signaling To Metabolic Processesmentioning

confidence: 99%

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Colardo

Martella

Pensabene

et al. 2021

IJMS

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Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells. In this context, it has been reported that neurotrophins affect redox balance, autophagy, glucose homeostasis and energy expenditure. Additionally, the trophic support provided by these secreted factors may involve the regulation of cholesterol metabolism. In this review, we examine the neurotrophins’ signaling pathways and their effects on metabolism by critically discussing the most up-to-date information. In particular, we gather experimental evidence demonstrating the impact of these growth factors on cholesterol metabolism.

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Section: Neurotrophins: From Cell Signaling To Metabolic Processesmentioning

confidence: 99%

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Colardo

Martella

Pensabene

et al. 2021

IJMS

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“…Prior research has repeatedly shown a substantial correlation between retinal microangiopathies and cardiovascular illnesses. 13 According to findings of a study by Ciccacci et al, 2013 polymorphism of the transcription factor 7-like 2 gene (TCF7L2), contributes to the development of both cardiac autonomic neuropathy and diabetic retinopathy. 14 According to our study's findings, diabetes patients' serum BDNF levels were lower than those of the control group.…”

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy and its relation to serum brain-derived neurotrophic factor level

El-Hamid

Farrag

El-Deen

2023

EJI

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Diabetes mellitus (DM) is a metabolic disorder of the proteins, lipids, and carbohydrates, results in hyperglycemia. Abnormalities in the function of insulin on target cells, its release from beta cells, or both may contribute to DM. The purpose of this research was to assess the progression of diabetic retinopathy (DR) to the levels of serum brain-derived neurotrophic factor (BDNF), glycated hemoglobin (HbA1c), and biochemical parameters. The study included 44 normal control subjects, 44 diabetic participants, who were separated into four groups based on their diabetes status and the results of fundoscopic examination. A commercial enzyme-linked immunosorbent assay kit was used to measure the levels of BDNF in the serum. The analysis revealed that diabetics had significantly lower serum BDNF levels than non-diabetics (p< 0.001). Also, there was a significant reduction in BDNF levels with the development of proliferative diabetic retinopathy in comparison with diabetics without DR (p < 0.001). In conclusion, serum BDNF levels decreased significantly in diabetics with and without DR compared to apparently healthy individuals, as well as with the progression of DR.

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Section: Discussionmentioning

confidence: 99%

Plasma brain natriuretic peptide, D-Dimer, and serum troponin-I as predictors for in-hospital death in patients with COVID-19

Mahmoud

El-Hafeez

Ali

et al. 2023

EJI

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The severe acute respiratory syndrome coronavirus 2, first appeared in Wuhan, China, in December 2019. Since then, a variety of strains of the virus were spread throughout the world, prompting the World Health Organization to declare a pandemic in March 2020. Additionally, Coronavirus disease 2019 (COVID-19) can cause a variety of symptoms, ranging from fatigue and fever to severe respiratory and cardiovascular complications. This study evaluated the role of brain natriuretic peptide (BNP), troponin-I and D-dimer as biomarkers for death prediction in hospitalized patients with COVID-19. The study included 90 patients with COVID -19 diagnosed with PCR-RNA testing. They were divided into survivors and non-survivors. Also, 20 apparently healthy individuals age and sex matched were included as a control group. Plasma BNP and serum troponin-I were measured by enzyme linked immune-sorbent assay (ELISA) technique. D-dimer was measured by a turbidimetric technique. Patients with COVID-19 had significantly elevated levels of serum Troponin-I and plasma BNP in comparison to controls (p< 0.0001, for both). D-dimer, troponin–I and BNP levels were significantly higher in the non-survivors group when compared to the survivors group. Troponin-1 can predict COVID-19 severity with sensitivity, specificity, and accuracy of 55.1%, 66.7%, and 57.8%, respectively at a cutoff value of 0.075 (ng /ml); and area under the receiver operating characteristic (AUC) curve of 0.670 (95% CI: 0.551 – 0.790, p=0.018). BNP can predict COVID-19 severity with sensitivity, specificity, and accuracy of 98.6%, 71.4%, 92.2%, respectively at a cutoff value of 16.02 (Pg /ml) and AUC of 0.872 (95% CI: 0.778 – 0.965, p<0.001). Univariate and multivariate logistic regression analysis showed that only BNP level can significantly predict death among COVID-19 infected patients. In conclusion, plasma BNP and serum troponin-I could be used as prognostic biomarkers for determination of the severity of COVID-19 and BNP could predict mortality.

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Comparison of Serum Brain-Derived Neurotrophic Factor Levels in Diabetic Patients With and Without Retinopathy

Cited by 6 publications

References 14 publications

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Diabetic retinopathy and its relation to serum brain-derived neurotrophic factor level

Plasma brain natriuretic peptide, D-Dimer, and serum troponin-I as predictors for in-hospital death in patients with COVID-19

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