Comparison of sensitivity and alcohol consumption in four outbred strains of rats

Khanna, J. M.; Kalant, H.; Shah, G.; Sharma, Harish

doi:10.1016/0741-8329(90)90027-a

Cited by 43 publications

(32 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both male rat lines increased their alcohol intake during post-deprivation days, but there were still no differences seen between male cLH and cNLH rats. However, it should be noted that the levels of alcohol intake in this study were low, which is not surprising since the cLH and cNLH lines derive from a Sprague-Dawley colony well known as outbred rats with a low intake of alcohol (Khanna et al 1990;Pare et al 1999;Henniger et al 2002). Nevertheless, it is known that significant changes in a rat's behavior can be induced by ingestion of as little as 0.2-0.3 g/kg of ethanol (Wolffgramm and Heyne 1995).…”

Section: Discussionmentioning

confidence: 83%

Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior

et al. 2004

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior

et al. 2004

View full text Add to dashboard Cite

show abstract

“…water) generally consumed significantly more alcohol compared with Fischer 344, Sprague-Dawley, and Wistar rats (Khanna et al, 1990). In the present study, we found that Long Evans rats, particularly driven by females, consumed more alcohol (voluntary intermittent two-bottle choice) and had a higher preference for alcohol (both continuous and intermittent voluntary two-bottle choice) compared with Wistar rats.…”

Section: Discussionmentioning

confidence: 97%

Sex, strain, and estrous cycle influences on alcohol drinking in rats

Priddy

Carmack

Thomas

et al. 2017

Pharmacology Biochemistry and Behavior

177

125

View full text Add to dashboard Cite

Although women appear to be more vulnerable to alcohol-induced pathophysiology than men, the neurobiological basis for sex differences is largely unknown, partially because most studies on alcohol drinking are conducted in male subjects only. The present study examined sex differences in alcohol consumption in two rat strains, Long Evans and Wistar, using multiple behavioral paradigms. The effects of the estrous cycle on alcohol consumption were monitored throughout the study. The results indicated that females drank more alcohol than males when given either continuous or intermittent access to alcohol (vs. water) in their home cages (voluntary drinking). Under operant conditions, no sex or strain differences were found in drinking prior to development of alcohol dependence. However, upon dependence induction by chronic, intermittent alcohol vapor exposure, Wistar rats of both sexes substantially escalated their alcohol intake compared with their nondependent drinking levels, whereas Long Evans rats only exhibited a moderate escalation of drinking. Under these conditions, the estrous cycle had no effect on alcohol drinking in any strain and drinking model. Thus, strain, sex, and drinking conditions interact to modulate nondependent and dependent alcohol drinking. The present results emphasize the importance of including sex and strain as biological variables in exploring individual differences in alcohol drinking and dependence.

show abstract

“…Schuckit and colleagues (2001) estimate that approximately 40% of children of alcoholics are relatively insensitive to ethanol while only 10% of children of non-alcoholics have this characteristic. Animal research has investigated whether these initial intrasessional factors are associated with subsequent chronic tolerance development or drug consumption by using rodents from outbred and inbred strains, as well as knock-out mice and selectively bred lines for drug consumption, drug sensitivity, and acute tolerance [e.g., outbred strains (Tabakoff and Culp 1984;San-Marina et al 1989;Khanna et al 1990b;Khanna et al 1991); inbred strains (Crabbe et al 1982;Tabakoff and Culp 1984;Khanna et al 1990a;Crabbe et al 1994;Gehle and Erwin 2000); knock-out mice (Naassila et al 2002); lines selectively bred for consumption (Tampier and Mardones 1999;Tampier et al 2000;Bell et al 2001); lines selectively bred for sensitivity (Khanna et al 1985;Crabbe et al 1989;Limm andCrabbe 1992: Crabbe 1994;Browman et al 2000;Deitrich et al 2000;Draski et al 2001;Palmer et al 2002); lines selectively bred for acute tolerance (Deitrich et al 2000;Rustay et al 2001;Wu et al 2001)]. While the scientific literature is in general agreement that initial sensitivity and acute tolerance are relevant to the subsequent development of chronic tolerance and drug consumption, a coherent description of this relationship has not emerged.…”

Section: Discussionmentioning

confidence: 99%

Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats

2005

View full text Add to dashboard Cite

Rationale: A preventive strategy for drug addiction would benefit from being able to identify vulnerable individuals. Understanding how an individual responds during an initial drug exposure may be useful for predicting how that individual will respond to repeated drug administrations.Objectives: This study investigated whether individual differences in initial drug sensitivity and acute tolerance can predict how chronic tolerance develops.Methods: During an initial 3-h administration of 60% nitrous oxide (N 2 O), male Long-Evans rats were screened for N 2 O's hypothermic effect into subsets based on being initially insensitive (II), sensitive with acute tolerance (AT), or sensitive with no intrasessional recovery (NR). Animals in each individual difference category were randomly assigned to receive six 90-min exposures of either 60% N 2 O or placebo gas. Core temperature was measured telemetrically.Results: Rats that exhibited a comparable degree of hypothermia during an initial N 2 O exposure, but differed in acute tolerance development, developed different patterns of chronic tolerance. Specifically, the NR group did not become fully tolerant over repeated N 2 O exposures while the AT group developed an initial hyperthermia followed by a return of core temperature to control levels indicative of full tolerance development. By the second N 2 O exposure, the II group breathing N 2 O became hyperthermic relative to the placebo control group and this hyperthermia persisted throughout the multiple N 2 O exposures.Conclusions: Individual differences in initial drug sensitivity and acute tolerance development predict different patterns of chronic tolerance. The hypothesis is suggested that individual differences in opponent adaptive responses may mediate this relationship.

show abstract

Comparison of sensitivity and alcohol consumption in four outbred strains of rats

Cited by 43 publications

References 13 publications

Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior

Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior

Sex, strain, and estrous cycle influences on alcohol drinking in rats

Individual differences in initial sensitivity and acute tolerance predict patterns of chronic drug tolerance to nitrous-oxide-induced hypothermia in rats

Contact Info

Product

Resources

About