Comparison of scaffold-enhanced albumin and n-butyl-cyanoacrylate adhesives for joining of tissue in a porcine model

McNally-Heintzelman, Karen M.; Riley, Jill N.; Heintzelman, Douglas L.

doi:10.1117/12.500109

Cited by 5 publications

(9 citation statements)

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“…1 Also, their polymerization reaction is noticeably exothermic and may result in thermal damage to tissues [6]. 2 Most alkyl cyanoacrylates are, therefore, restricted to topical skin use only.…”

Section: Introductionmentioning

confidence: 99%

“…Tissue adhesives represent a preferred alternative to suturing or stapling [1][2][3], provided they bind tissue planes rapidly and assure a tight and strong closure until healing is completed. In addition, a tissue adhesive must be biocompatible [4,5] and, since it has not to interfere with the healing process, it has to gradually degrade as required [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Tailoring lactide/caprolactone co-oligomers as tissue adhesives

Cohn

Lando

2004

Biomaterials

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tailoring lactide/caprolactone co-oligomers as tissue adhesives

Cohn

Lando

2004

Biomaterials

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“…Figure 11 demonstrates the influence of solder composition and the scaffold's thermo-mechanical properties on acute and post-hydration welding strength. As with sLAVR, a higher solder protein concentration produced stronger repairs than lower protein concentrations [91,93,94,98,102,103,104]. The reduction in solder leakage was achieved by semi-solidification of the solder.…”

Section: Laser-scaffold Interactionsmentioning

confidence: 99%

“…Moreover, the possibility of producing tube scaffolds allows the future application for end-to-end or end-to-side anastomoses of medium-sized vessels [58,97,102]. In addition to vascular anastomosis, ssLAVW can also be used as an immediate extra-vascular sealant [99,104].…”

Section: Drawbacks Of Slavwmentioning

confidence: 99%

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Laser-assisted vessel welding: state of the art and future outlook

Pabittei

Boon

Heger

et al. 2015

JCTRes

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Laser-assisted vascular welding (LAVW) is an experimental technique being developed as an alternative to suture anastomosis. In comparison to mechanical anastomosis, LAVW is less traumatic, non-immunogenic, provides immediate water tight sealant, and possibly a faster and easier procedure for minimally invasive surgery. This review focuses on technical advances to improve welding strength and to reduce thermal damage in LAVW. In terms of welding strength, LAVW has evolved from the photothermally-induced microvascular anastomosis, requiring stay sutures to support welding strength, to sutureless anastomoses of medium-sized vessels, withstanding physiological and supraphysiological pressure. Further improvements in anastomotic strength could be achieved by the use of chromophore-containing albumin solder and the employment of (biocompatible) polymeric scaffolds. The anastomotic strength and the stability of welds achieved with such a modality, referred to as scaffold-and solder-enhanced LAVW (ssLAVW), are dependent on the intermolecular bonding of solder molecules (cohesive bonding) and the bonding between solder and tissue collagen (adhesive bonding). Presently, the challenges of ssLAVW include (1) obtaining an optimal balance between cohesive and adhesive bonding and (2) minimizing thermal damage. The modulation of thermodynamics during welding, the application of semi-solid solder, and the use of a scaffold that supports both cohesive and adhesive strength are essential to improve welding strength and to limit thermal damage.

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