“…Quality assessment showed one study with a low risk of bias for all four items 18 , two studies with a high risk of bias for two of the items (description of index test and reference standard) 14,15 , while four studies had an unclear risk of bias for the description of flow and timing [14][15][16][17] . Three studies had low risk for the three items of applicability [16][17][18] .…”
Section: Quality Assessmentmentioning
confidence: 99%
“…For detection of endometrial polyps, sensitivity and specificity of 2D-SCSH ranged from 88% to 98% and from 61% to 100% among the five studies, respectively ( Figure 2). Pooled analysis gave sensitivity and specificity of 93% (95% CI, 89-96%) and 81% (95% CI, 76-86%), respectively [14][15][16][17][18] . Pooled LR+ was 5.41 (95% CI, 2.60-11.28) and LR-was 0.10 (95% CI, 0.06-0.17).…”
Section: Data Synthesismentioning
confidence: 99%
“…Pooled analysis gave sensitivity and specificity of 94% (95% CI, 89-97%) and 81% (95% CI, 76-86%), respectively 14,15,17,18 . Pooled LR+ was 4.25 (95% CI, 2.20-8.21) and LR-was 0.11 (95% CI, 0.05-0.22).…”
Section: Data Synthesismentioning
confidence: 99%
“…Pooled LR+ was 5.41 (95% CI, 2.60-11.28) and LR-was 0.10 (95% CI, 0.06-0.17). 17 The Netherlands 62 0 44 (36-54) Proliferative 2D-SCSH Hysteroscopy Soguktas (2012) 18 Turkey 89 NA 43.1 ± 2.9 NA 2D-SCSH Hysteroscopy…”
Section: Data Synthesismentioning
confidence: 99%
“…The five studies included in the review were effectively cross-sectional without sample size calculation, each conducted at a single institution, including a total of 543 women [14][15][16][17][18] . Average patient age was 40 years, with the mean age among studies ranging from 30.6 to 44 years.…”
“…Quality assessment showed one study with a low risk of bias for all four items 18 , two studies with a high risk of bias for two of the items (description of index test and reference standard) 14,15 , while four studies had an unclear risk of bias for the description of flow and timing [14][15][16][17] . Three studies had low risk for the three items of applicability [16][17][18] .…”
Section: Quality Assessmentmentioning
confidence: 99%
“…For detection of endometrial polyps, sensitivity and specificity of 2D-SCSH ranged from 88% to 98% and from 61% to 100% among the five studies, respectively ( Figure 2). Pooled analysis gave sensitivity and specificity of 93% (95% CI, 89-96%) and 81% (95% CI, 76-86%), respectively [14][15][16][17][18] . Pooled LR+ was 5.41 (95% CI, 2.60-11.28) and LR-was 0.10 (95% CI, 0.06-0.17).…”
Section: Data Synthesismentioning
confidence: 99%
“…Pooled analysis gave sensitivity and specificity of 94% (95% CI, 89-97%) and 81% (95% CI, 76-86%), respectively 14,15,17,18 . Pooled LR+ was 4.25 (95% CI, 2.20-8.21) and LR-was 0.11 (95% CI, 0.05-0.22).…”
Section: Data Synthesismentioning
confidence: 99%
“…Pooled LR+ was 5.41 (95% CI, 2.60-11.28) and LR-was 0.10 (95% CI, 0.06-0.17). 17 The Netherlands 62 0 44 (36-54) Proliferative 2D-SCSH Hysteroscopy Soguktas (2012) 18 Turkey 89 NA 43.1 ± 2.9 NA 2D-SCSH Hysteroscopy…”
Section: Data Synthesismentioning
confidence: 99%
“…The five studies included in the review were effectively cross-sectional without sample size calculation, each conducted at a single institution, including a total of 543 women [14][15][16][17][18] . Average patient age was 40 years, with the mean age among studies ranging from 30.6 to 44 years.…”
This is the first meta-analysis comparing transvaginal sonography (TVS) and saline contrast sonohysterography (SCSH) for detecting endometrial polyps in studies reporting a specific definition for this pathology and in which all women underwent both tests. SCSH seems to have superior diagnostic accuracy in both pre-and postmenopausal women. What are the clinical implications of this work? Given that SCSH has better diagnostic positive and negative likelihood ratios than does TVS, patients with clinical suspicion of endometrial polyps should undergo SCSH if TVS findings are inconclusive.
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