Comparison of response indices to toxic microcystin-LR in blood of mice

Huang, Xuanping; Zhang, Yonglu; Xiao, Wenqing; Ye, Xiaoyan; Zhong, Qing; Gu, Kangding

doi:10.1016/j.chemosphere.2013.04.006

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…Several authors, Cazenave et al (2006), Prieto et al (2006), Sun et al (2008), Chen et al (2009), He et al (2010), Zhao et al (2011) and Huang et al (2013) and references cited have reported the toxicity of MCs to fish, animals and humans.…”

Section: Introductionmentioning

confidence: 99%

“…During growth and decay, cyanobacteria deplete dissolved oxygen (hypoxia) and release microcystins (MCs), which create environmental stress Huang et al, 2013). Microcystins (MCs) are produced by cyanobacteria such as Anabaena flos-aquae and Microcystis aeruginosa, and have the general structure of: cyclo-(D-alanine1-X2-D-MeAsp3-Z4-Adda5-D-glutamate6-Mdha7) (Campos and Vasconcelos, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level

et al. 2014

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“…To date, a large number of studies have shown that MCs can induce cardiovascular toxicity in vivo and vitro directly [36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53]. Table 1 and Table 2 represent summaries of cardiovascular toxicity in in vivo and vitro studies, respectively.…”

Section: Cardiovascular Toxicity Of Mcsmentioning

confidence: 99%

“…injection of MC-LR at a dose of 100 μg/kg bw. Huang et al [47] investigated the response indices to toxic MC-LR in the blood of mice with I.P. injection at different MC-LR concentrations and indicated that the phagocytic index, ROS, hematology of the majority of blood cells and volume of erythrocytes were influenced by the toxin.…”

Section: Cardiovascular Toxicity Of Mcsmentioning

confidence: 99%

“…injection at different MC-LR concentrations and indicated that the phagocytic index, ROS, hematology of the majority of blood cells and volume of erythrocytes were influenced by the toxin. In addition, the alterations of some cytokines and ROS of leukocytes were observed [47]. Another in vivo study also showed a significant difference in red blood cell parameters (red blood cell counts, haematocrit values, mean corpuscular hemoglobin, mean corpusular volume and mean corpusular hemoglobin concerntration) when rats were fed with fish meat with and without MCs for 28 days [48].…”

Section: Cardiovascular Toxicity Of Mcsmentioning

confidence: 99%

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A Review of Cardiovascular Toxicity of Microcystins

Cao

Massey

Feng

et al. 2019

Toxins

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The mortality rate of cardiovascular diseases (CVD) in China is on the rise. The increasing burden of CVD in China has become a major public health problem. Cyanobacterial blooms have been recently considered a global environmental concern. Microcystins (MCs) are the secondary products of cyanobacteria metabolism and the most harmful cyanotoxin found in water bodies. Recent studies provide strong evidence of positive associations between MC exposure and cardiotoxicity, representing a threat to human cardiovascular health. This review focuses on the effects of MCs on the cardiovascular system and provides some evidence that CVD could be induced by MCs. We summarized the current knowledge of the cardiovascular toxicity of MCs, with regard to direct cardiovascular toxicity and indirect cardiovascular toxicity. Toxicity of MCs is mainly governed by the increasing level of reactive oxygen species (ROS), oxidative stress in mitochondria and endoplasmic reticulum, the inhibition activities of serine/threonine protein phosphatase 1 (PP1) and 2A (PP2A) and the destruction of cytoskeletons, which finally induce the occurrence of CVD. To protect human health from the threat of MCs, this paper also puts forward some directions for further research.

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Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation

et al. 2017

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Cyanobacteria were present on the earth 3.5 billion years ago; since then they have colonized almost all terrestrial and aquatic ecosystems. They produce a high number of bioactive molecules, among which some are cyanotoxins. Cyanobacterial growth at high densities, forming blooms, is increasing in extension and frequency, following anthropogenic activities and climate changes, giving rise to some concern for human health and animal life exposed to cyanotoxins. Numerous cases of lethal poisonings have been associated with cyanotoxins ingestion in wild animal and livestock. In humans few episodes of lethal or severe human poisonings have been recorded after acute or short-term exposure, but the repeated/chronic exposure to low cyanotoxin levels remains a critical issue. The properties of the most frequently detected cyanotoxins (namely, microcystins, nodularins, cylindrospermopsin and neurotoxins) are here critically reviewed, describing for each toxin the available information on producing organisms, biosynthesis/genetic and occurrence, with a focus on the toxicological profile (including kinetics, acute systemic toxicity, mechanism and mode of action, local effects, repeated toxicity, genotoxicity, carcinogenicity, reproductive toxicity; human health effects and epidemiological studies; animal poisoning) with the derivation of health-based values and considerations on the risks for human health.

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Comparison of response indices to toxic microcystin-LR in blood of mice

Cited by 14 publications

References 24 publications

Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level

Organ-dependent response in antioxidants, myoglobin and neuroglobin in goldfish (Carassius auratus) exposed to MC-RR under varying oxygen level

A Review of Cardiovascular Toxicity of Microcystins

Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation

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