Comparison of Relaxations Evoked by Photoactivation of NO-Containing Compounds and Nitrergic Nerve Stimulation in 5-Hydroxytryptamine- and Potassium-Contracted Rat Gastric Fundus

Chang, Ki-Churl; Koo, Eui-Bon; Goun-Woo, Lee; Kang, Young-Jin; Lee, Hoi-Young

doi:10.1016/s0306-3623(97)00326-1

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Although the physiological relevance of such a store remains obscure, it has been implicated in vascular tone regulation in spontaneously hypertensive rats (Kubaszewski et al 1994). A similar intrinsic photo-relaxant response has also been reported in the gastric fundus of the dog (Ozaki et al 1992) and the mouse ( O g ulener et al 1996), but not in the rat (Chang et al 1998), although its physiological implications have not been studied further. Except for these few reports, non-vascular smooth muscle from gastrointestinal (Ehrreich & Furchgott, 1968;Trivedi et al 1978), respiratory (Chang et al 1993) and genital tracts (Ehrreich & Furchgott, 1968) and urinary bladder (Ehrreich & Furchgott, 1968;Chung et al 1996) in different animal species has been shown to be insensitive to light irradiation, although it can develop a significant relaxation in the presence of compounds with a nitromoiety, through their photo-cleavage and NO generation.…”

mentioning

confidence: 86%

Spontaneous photo‐relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission

Triguero

Costa

Labadía

et al. 2000

The Journal of Physiology

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In the present work we have characterized the relaxant response induced by light stimulation (LS) in the lower urinary tract from sheep, pig and rat, establishing its relationship with nitrergic neurotransmission. Urethral, but not detrusor, preparations showed pronounced photo‐relaxation (PR) which declined progressively following repetitive LS. Sheep urethral PR was again restored either spontaneously or (to a greater extent) by exogenous nitric oxide (NO) addition and by electrical field stimulation (EFS) of intrinsic nitrergic nerves. Greater NO generation was detected from sheep urethral than from detrusor homogenates following illumination. Sheep urethral PR was inhibited by oxyhaemoglobin, but not by methaemoglobin, carboxy‐PTIO, extracellular superoxide anion generators or superoxide dismutase. Guanylyl cyclase but not adenylyl cyclase activation mediates urethral relaxation to LS. Urethral PR was more resistant to inhibition by L‐thiocitrulline than EFS‐induced responses, although this agent prevented PR restoration by high‐frequency EFS. Urethral PR was TTX insensitive and partially modified in high‐K+ solutions. Cold storage for 24 h greatly impaired urethral PR, although it was restored by high‐frequency EFS. Repetitive exposure to LS, EFS or exogenous NO induced changes in the shape of the EFS‐induced nitrergic relaxation, possibly by pre‐synaptic mechanisms. In conclusion, we suggest the presence of an endogenous, photo‐labile, nitro‐compound store in the urethra, which seems to be replenished by neural nitric oxide synthase activity, indicating a close functional relationship with the nitrergic neurotransmitter.

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confidence: 86%

Spontaneous photo‐relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission

Triguero

Costa

Labadía

et al. 2000

The Journal of Physiology

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“…A cyclic GMP-dependent mechanism appears to be involved in the nitrergic relaxation of the rat and mouse gastric fundus (Williams and Parsons, 1995;Chang et al, 1998;Bayguinov et al, 1999;Selemidis and Cocks, 2000). Cyclic GMP-dependent protein kinase I apparently plays a key role in the NO/cyclic GMP signaling pathway in the mouse gastric fundus (Ny et al, 2000).…”

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confidence: 99%

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Toda

Herman

2005

Pharmacol Rev

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“…The slopes in (a) for all the tumors were classified into two groups: without pretreatment and with pretreatment. A t-test between these two groups of slopes gives rise to P 5 0.95. upregulation of nitric oxide, and thus, produce vasodilation (41)(42)(43). The increase of tumor blood contents due to laser irradiation observed in our study may be attributed to the vessel dilation induced by the direct effect of heating as well as photoactivation.…”

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confidence: 99%

Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure

Xia¹,

Liu²

2007

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Comparison of Relaxations Evoked by Photoactivation of NO-Containing Compounds and Nitrergic Nerve Stimulation in 5-Hydroxytryptamine- and Potassium-Contracted Rat Gastric Fundus

Cited by 10 publications

References 24 publications

Spontaneous photo‐relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission

Spontaneous photo‐relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission

Gastrointestinal Function Regulation by Nitrergic Efferent Nerves

Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure

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