Comparison of Recovery From Anaesthesia Induced in Children With Either Propofol or Thiopentone

Abstract

We studied 102 children undergoing day-case surgery, allocated randomly to receive either thiopentone 5 mg kg-1 or propofol 3 mg kg-1 i.v. at induction of anaesthesia. They then inhaled nitrous oxide and halothane in oxygen until a laryngeal mask airway could be inserted. Thereafter, halothane was substituted by isoflurane and analgesia provided by regional nerve block. Recovery from anaesthesia was assessed by the time taken to reach clinically-defined criteria and by calculation of sedation, pain and vomiting scores. In children aged less than 5 yr, only the time to spontaneous eye opening was shorter after propofol induction (P < 0.05). In children aged 5-11 yr, times of spontaneous eye opening, giving name and discharge were shorter after propofol induction (P < 0.05). These results indicate that propofol hastened early recovery in children undergoing day-case surgery, but earlier discharge occurred only in older children.

Effects of intramuscular and peritonsillar injection of tramadol before tonsillectomy: A double blind, randomized, placebo-controlled clinical trial

“…The duration and intensity of the pain may change according to several factors including the individual patient perception of the pain, surgical technique, antibiotics, corticosteroids, posttonsillectomy analgesia, and preemptive analgesia [1,2,30]. Propofol provides satisfactory and stable anesthesia for children with rapid and complete recovery [31,32]. Propofol possessed only hypnotic properties in which additional analgesia was necessary; therefore, changes in heart rate and blood pressure may occur in response to pain during propofol anesthesia with controlled ventilation [4].…”

Dosage scheme for propofol in children under 3 years of age

“…In the adapted scheme, the dosage in the youngest age group is relatively the highest and is lower for older age groups. This was based on the model of partition of propofol, which is a 3‐compartment model (3– 6,11– 16).…”

“…After stopping the infusion, the children were smoothly awake within 15 min, the majority within 10 min (93%), independent of the duration of the infusion of propofol. The patients often did not require an extra bolus of propofol during the surgery (2,8,12,15– 18,22– 25).…”

Assessment of Intubating Conditions with Different Doses of Propofol without Muscle Relaxant in Children

“…The induction with propofol is quick and smooth, with rapid awakening during recovery [15].With the adjuvant of shortacting opioids, their use in combination with propofol for tracheal intubation without neuromuscular blocking agents has been well documented [1,[4][5][6]. Numerous studies have stressed the advantages of propofol, such as a low cumulative effect which offers fast recovery of consciousness after surgery, an antiemetic effect, a diminished pressor response to laryngoscopy and tracheal intubation, and a lower incidence of airway complications, in adults and pediatric patients [16,17]. However, a larger apparent volume of distribution for propofol is consistent with a higher induction dose requirement in children than in adults [18].…”