Comparison of radon lung dosimetry models for the estimation of dose uncertainties

Winkler-Heil, Renate; Hofmann, Werner; Marsh, J. Wallis; Birchall, А.

doi:10.1093/rpd/ncm339

Cited by 39 publications

(36 citation statements)

References 7 publications

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“…As a consequence, uncertainty in dose estimates arises from individual variability and from epistemic uncertainty in the structure and parameter values of the model. While there are important differences in the assumptions made, the calculated lung doses did not differ significantly between the models under mining exposure conditions (18,37). Notably, it is acknowledged [ref.…”

Section: Strengths and Limitationsmentioning

confidence: 92%

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Leuraud¹,

Schnelzer

Tomášek

et al. 2011

Radiation Research

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A combined analysis of three case-control studies nested in three European uranium miner cohorts was performed to study the joint effects of radon exposure and smoking on lung cancer death risk. Occupational history and exposure data were available from the cohorts. Smoking information was reconstructed using self-administered questionnaires and occupational medical archives. Linear excess relative risk models adjusted for smoking were used to estimate the lung cancer risk associated with radon exposure. The study includes 1046 lung cancer cases and 2492 controls with detailed radon exposure data and smoking status. The ERR/WLM adjusted for smoking is equal to 0.008 (95% CI: 0.004-0.014). Time since exposure is shown to be a major modifier of the relationship between radon exposure and lung cancer risk. Fitting geometric mixture models yielded arguments in favor of a sub-multiplicative interaction between radon and smoking. This combined study is the largest case-control study to investigate the joint effects of radon and smoking on lung cancer risk among miners. The results confirm that the lung carcinogenic effect of radon persists even when smoking is adjusted for, with arguments in favor of a sub-multiplicative interaction between radon and smoking.

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Section: Strengths and Limitationsmentioning

confidence: 92%

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Leuraud¹,

Schnelzer

Tomášek

et al. 2011

Radiation Research

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show abstract

“…Assuming a WLM-tolung dose conversion factor of 4 mGy per WLM, 25 the mean cumulative lung dose from radon is B100 mGy, which is significantly larger than lung dose from either external exposure or internally deposited uranium, on average. The International Agency for Research on Cancer classifies radon as a human carcinogen 26 because of evidence of an association between radon and lung cancer summarized in the BEIR VI report.…”

Section: Discussionmentioning

confidence: 99%

Exposure assessment for a cohort of workers at a former uranium processing facility

Anderson

Daniels

Fleming

et al. 2012

J Expo Sci Environ Epidemiol

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“…Les principales évaluations de dose absorbée par les cellules épithéliales du poumon recensées par l'UNSCEAR (2000) s'étalent sur un ordre de grandeur entre 5,7 (Harley et Pasternack, 1972) et 71 (Haque et Collinson, 1967) nGy par Bq h m -3 EEC. Des études détaillées de la contribution des différentes sources d'incertitude dosimétrique ont été effectuées par Birchall et James (1994), Porstendörfer (2001), Marsh et al (2002), James et al (2004) et Winkler-Heil et al (2007.…”

Section: Discussionunclassified

Dosimétrie du radon : les points de vue de l’UNSCEAR et de la CIPR sont-ils contradictoires ?

et al. 2009

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RÉSUMÉThe conversion of radon exposure into dose is being debated. The UNSCEAR defined a coefficient for conversion of radon concentration into effective dose from dosimetric models and epidemiological studies. The ICRP recommends evaluating the risk associated with radon exposure from epidemiological studies. To account for possible combined exposure to other sources of ionizing radiation, the ICRP adopted, on the basis of the epidemiological follow-up of uranium miners, effective dose conversion conventions which are 10 to 30% lower than the UNSCEAR coefficient. As a consequence, different reference levels for radon concentration can be derived from a single level of effective dose by applying either conversion factor. Still, it should be stressed that these differences are negligible when compared with the uncertainty associated with both dosimetric and epidemiological studies, and that the reference levels are mainly tools to help in reducing radon exposure and the associated risk as low as reasonably achievable. Article published by EDP Sciences and available at http://www.radioprotection.org or http://dx

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Comparison of radon lung dosimetry models for the estimation of dose uncertainties

Cited by 39 publications

References 7 publications

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Exposure assessment for a cohort of workers at a former uranium processing facility

Dosimétrie du radon : les points de vue de l’UNSCEAR et de la CIPR sont-ils contradictoires ?

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