Exposure assessment for a cohort of workers at a former uranium processing facility

Anderson, Jeri L.; Daniels, Robert D.; Fleming, Donald A.; Tseng, Chih‐Yu

doi:10.1038/jes.2012.20

Cited by 17 publications

(13 citation statements)

References 22 publications

(20 reference statements)

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“…Overall the doses were low but not unexpected compared to exposure at other facilities. For example, median organ absorbed doses estimated were 0.053, 0.0015, and 0.0044 mGy for lung, red bone marrow, and kidney, respectively for the Fernald cohort [Anderson et al, ]. The median lung, red bone marrow, and kidney organ absorbed doses, respectively in our cohort were 0.0204, 0.0878, and 0.2995 mGy.…”

Section: Resultsmentioning

confidence: 48%

Mortality in a combined cohort of uranium enrichment workers

Yiin

Anderson

Daniels

et al. 2016

American J Industrial Med

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Objective To examine the patterns of cause-specific mortality and relationship between internal exposure to uranium and specific causes in a pooled cohort of 29,303 workers employed at three former uranium enrichment facilities in the United States with follow-up through 2011. Methods Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Internal comparison of the dose-response relation between selected outcomes and estimated organ doses was evaluated using regression models. Results External comparison with the U.S. population showed significantly lower SMRs in most diseases in the pooled cohort. Internal comparison showed positive associations of absorbed organ doses with multiple myeloma, and to a lesser degree with kidney cancer. Conclusion In general, these gaseous diffusion plant workers had significantly lower SMRs than the U.S. population. The internal comparison however, showed associations between internal organ doses and diseases associated with uranium exposure in previous studies.

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Section: Resultsmentioning

confidence: 48%

Mortality in a combined cohort of uranium enrichment workers

Yiin

Anderson

Daniels

et al. 2016

American J Industrial Med

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“…Through 2004, a total of 2771 workers (43%) had died, with 860 of these deaths due to malignancies. Organ dose, external dose and RDP exposure distributions for the full cohort are summarised in table 1 and described in-depth in Anderson et al 11 A total of 348 workers had dose records at other facilities; the collective dose added from this offsite component was 1.29 person-Gy.…”

Section: Resultsmentioning

confidence: 99%

“…The exposure assessment is described in detail in Anderson et al 11 and briefly here. The exposure assessors were blinded to case status.…”

Section: Methodsmentioning

confidence: 99%

Mortality and ionising radiation exposures among workers employed at the Fernald Feed Materials Production Center (1951–1985)

et al. 2013

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Objectives-To examine mortality patterns and dose-response relations between ionising radiation and mortality outcomes of a priori interest in 6409 uranium workers employed for at least 30 days , and followed through 2004.Methods-Cohort mortality was evaluated through standardised mortality ratios (SMR). Linear excess relative risk (ERR) regression models examined associations between cause-specific mortality and exposures to internal ionising radiation from uranium deposition, external gamma and x-ray radiation, and radon decay products, while adjusting for non-radiologic covariates.Results-Person-years at risk totalled 236 568 (mean follow-up 37 years), and 43% of the cohort had died. All-cause mortality was below expectation only in salaried workers. Cancer mortality was significantly elevated in hourly males, primarily from excess lung cancer (SMR=1.25, 95% CI 1.09 to 1.42). Cancer mortality in salaried males was near expectation, but lymphohaematopoietic malignancies were significantly elevated (SMR=1.52, 95% CI 1.06 to 2.12). A positive dose-response relation was observed for intestinal cancer, with a significant elevation in the highest internal organ dose category and a significant dose-response with organ dose from internal uranium deposition (ERR=1.5 per 100 µGy, 95% CI 0.12 to 4.1).

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“…In another cohort mortality study of uranium workers at the Fernald Feed Materials Production Center (FMPC), intakes and organ doses from exposure to uranium were estimated using methods similar to this study (15) . FMPC median (interquartile range) estimated intakes were 0.045 (0.0018–0.81) Bq d −1 , and organ absorbed doses were 0.053 (0.0023–0.59), 0.0015 (0.000061–0.018), 0.0044 (0.00019–0.051) and 0.0015 (0.000054–0.018) mGy for lung, red bone marrow, kidney and liver, respectively.…”

Section: Resultsmentioning

confidence: 99%

Internal exposure to uranium in a pooled cohort of gaseous diffusion plant workers

Anderson

Apostoaei

Yiin

et al. 2015

Radiat Prot Dosimetry

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Intakes and absorbed organ doses were estimated for 29 303 workers employed at three former US gaseous diffusion plants as part of a study of cause-specific mortality and cancer incidence in uranium enrichment workers. Uranium urinalysis data (>600 000 urine samples) were available for 58 % of the pooled cohort. Facility records provided uranium gravimetric and radioactivity concentration data and allowed estimation of enrichment levels of uranium to which workers may have been exposed. Urine data were generally recorded with facility department numbers, which were also available in study subjects’ work histories. Bioassay data were imputed for study subjects with no recorded sample results (33 % of pooled cohort) by assigning department average urine uranium concentration. Gravimetric data were converted to 24-h uranium activity excretion using department average specific activities. Intakes and organ doses were calculated assuming chronic exposure by inhalation to a 5-µm activity median aerodynamic diameter aerosol of soluble uranium. Median intakes varied between 0.31 and 0.74 Bq d−1 for the three facilities. Median organ doses for the three facilities varied between 0.019 and 0.051, 0.68 and 1.8, 0.078 and 0.22, 0.28 and 0.74, and 0.094 and 0.25 mGy for lung, bone surface, red bone marrow, kidneys, and liver, respectively. Estimated intakes and organ doses for study subjects with imputed bioassay data were similar in magnitude.

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Exposure assessment for a cohort of workers at a former uranium processing facility

Cited by 17 publications

References 22 publications

Mortality in a combined cohort of uranium enrichment workers

Mortality in a combined cohort of uranium enrichment workers

Mortality and ionising radiation exposures among workers employed at the Fernald Feed Materials Production Center (1951–1985)

Internal exposure to uranium in a pooled cohort of gaseous diffusion plant workers

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