Comparison of Radiofrequency Ablation, Cryoablation, and Nephrectomy in Treating Implanted VX-2 Carcinoma in Rabbit Kidneys

Nakada, Stephen Y.; Jerde, Travis J.; Warner, Thomas F.; Lee, Fred T.

doi:10.1089/0892779041271661

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…There was no significant difference between the results of RFA, cryoablation and nephrectomy in small rabbit kidney tumors of less than 1 cm. All these treatment modalities were efficient 27 . Moreover, there was no impact of RFA on renal function and blood pressure after ablation of small tumors 28 .…”

Section: Discussionmentioning

confidence: 99%

Percutaneous ultrasound‐guided radiofrequency ablation for kidney tumors in patients with surgical risk

Salagierski¹,

Salagierska-Barwińska²,

Sosnowski³

2006

Int J of Urology

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Section: Discussionmentioning

confidence: 99%

Percutaneous ultrasound‐guided radiofrequency ablation for kidney tumors in patients with surgical risk

Salagierski¹,

Salagierska-Barwińska²,

Sosnowski³

2006

Int J of Urology

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“…Another advantage of focused transducers is the short duration of treatment (less than 10 s, which may be further reduced by optimization), making this thermal modality competitive with cryoablation and radiofrequency ablation [42][43][44]. Furthermore, this non-invasive and short-term treatment with dual-mode technology can be clinically applied to skin rejuvenation and tightening via heating of tissue to 65-70 • C, which causes collagen contraction, denaturation, and initiation of collagen synthesis [45,46].…”

Section: Discussionmentioning

confidence: 99%

Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results

Lim

Kim

et al. 2021

Sensors

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We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical systems have been developed for lesion monitoring to ensure that ultrasonic treatment is correctly administered at the right locations. In this study, we developed a dual-element transducer composed of two elements that share the same housing but work independently with a BTB structure, enabling a mode change between therapy and imaging via 180-degree mechanical rotation. The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. Images were obtained in vivo mice before and after treatment and compared to identify the treated region. We successfully acquired B-mode and C-scan images that display the hyperechoic region indicating coagulation necrosis in the HIFU-treated volume up to a depth of 10 mm. The compact BTB dual-mode ultrasonic transducer may be used for subcutaneous thermal ablation and monitoring, minimally invasive surgery, and other clinical applications, all with ultrasound only.

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“…In a study using an animal model [13] , it was suggested that RFA gave a higher cure rate and a lower rate of metastatic disease in the kidney cancer management. This outcome could be the result of the combination of tumour destruction and coagulation of perirenal fat during RFA [13] .…”

Section: Discussionmentioning

confidence: 99%

“…This outcome could be the result of the combination of tumour destruction and coagulation of perirenal fat during RFA [13] . This might suggest that our method of ablation may give a better chance of reduced tumour recurrence than the standard PN.…”

Section: Discussionmentioning

confidence: 99%

Haemostatic Radiofrequency Ablation Assisted Partial Nephrectomy: Is Radiofrequency Energy a Viable Solution?

Salagierski

2008

Urol Int

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Aim: We present our experience with partial nephrectomy using radiofrequency energy in patients with kidney cancer. Methods: From July 2002 to February 2007, 15 radiofrequency ablation assisted partial nephrectomies were performed. Five patients had one kidney only. The average tumour size was 34 (range 22–55) mm, and the mean age was 56 (range 45–69) years. The renal pedicle was not clamped. A monopolar cool-tip radiofrequency device under intra-operative ultrasound guidance was used. Our procedure involved inserting a radiofrequency probe around the tumour. The average ablation time was 6–12 min. Afterwards the tumour was removed and analyzed histopathologically. Results: The average follow-up period was 15 (range 1–42) months. Eleven procedures were performed without any complications. In 4 cases, delayed urine leakage was observed. Histopathological examination revealed 13 clear cell renal cell carcinomas and 2 oncocytomas. In all cases the coagulated surgical margins were negative. Currently, the surviving patients have a well-preserved renal function, and there was no tumour recurrence. Conclusions: Radiofrequency ablation assisted partial nephrectomy seems to be an effective method of nephron-sparing surgery. The major advantages of this procedure include easy tumour extraction and no signs of bleeding.

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Comparison of Radiofrequency Ablation, Cryoablation, and Nephrectomy in Treating Implanted VX-2 Carcinoma in Rabbit Kidneys

Abstract: Radiofrequency ablation, cryoablation, and radical nephrectomy were all efficacious in the treatment of implanted VX-2 renal tumors compared with untreated controls (P = 0.002). No statistically significant difference was found between any of the three treatments.

Cited by 9 publications

References 16 publications

Percutaneous ultrasound‐guided radiofrequency ablation for kidney tumors in patients with surgical risk

Percutaneous ultrasound‐guided radiofrequency ablation for kidney tumors in patients with surgical risk

Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results

Haemostatic Radiofrequency Ablation Assisted Partial Nephrectomy: Is Radiofrequency Energy a Viable Solution?

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