Comparison of radical and partial nephrectomy in terms of renal function: A retrospective cohort study

Süer, Evren; Burgu, Berk; Gökçe, Mehmet İlker; Türkölmez, Kadír; Bedük, Yaşar; Baltacı, Sümer

doi:10.3109/00365599.2010.521186

Cited by 27 publications

(23 citation statements)

References 15 publications

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“…This is consistent with the results of previous studies [9,15,16]. RN has previously been found to be associated with a greater risk of de novo chronic renal failure than PN is [1,3,8,9,10,11], and our results similarly demonstrated that this risk was significantly greater in the RN group.…”

Section: Discussionsupporting

confidence: 94%

“…eGFR can be determined at a lower cost and more conveniently and is suitable for clinical use. It has therefore been used in several studies assessing renal function after operations for RCC [8,9]. The Modification of Diet in Renal Disease (MDRD) Study equation is most commonly used to estimate GFR [13], but this equation is less accurate for Asians, with greater bias at eGFR of <60 ml/min/1.73 m 2 [14].…”

Section: Discussionmentioning

confidence: 99%

“…We therefore compared the time-dependent changes of renal function after RN or PN with the time-dependent changes of eGFR. Several studies have also identified risk factors for renal insufficiency after RN or PN [3,8,9,10,11], but those studies evaluated only preoperative characteristics. In the present study, we evaluated additional factors such as operation time, bleeding volume, and postoperative urine volume because we thought they could affect renal function after an operation for RCC.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma

et al. 2012

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Objective: To investigate the time-dependent changes of estimated glomerular filtration rate (eGFR) after radical nephrectomy (RN) and partial nephrectomy (PN) for renal cell carcinoma (RCC) and to determine the risk factors for the new onset of a postoperative eGFR <60 ml/min/1.73 m². Patients and Methods: We assessed the renal function of 253 RCC patients by using the eGFR, and investigated the time-dependent changes of the eGFR after the operation. Regression models were used to determine risk factors for the new onset of an eGFR of <60 ml/min/1.73 m² in 211 patients who had at least one month of postoperative follow-up. Results: From the first postoperative day to the 60th postoperative month the eGFR in the RN group was significantly lower than that in the PN group. For patients who had at least 1 month of postoperative follow-up, multivariable analysis revealed that RN (p < 0.001), age (p = 0.028), and maleness (p = 0.013) were risk factors for the postoperative onset of an eGFR <60 ml/min/1.73 m². Conclusions: Renal function after PN was better than that after RN, and RN was a greater risk factor for the postoperative onset of an eGFR <60 ml/min/ 1.73 m².

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma

et al. 2012

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“…The loss of renal function is decreased following PN compared with that following radical nephrectomy (RN), and oncological management is reportedly equivalent between PN and RN (1,4). Although patients following RN are not likely to exhibit severe renal dysfunction requiring hemodialysis (5,6), 65% of patients develop grade 3 chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m 3 , 3 years after nephrectomy (7) and the decrease in eGFR may lead to an increased risk of cardiovascular-related death in the future (8,9). Therefore, the preservation of renal function as well as cancer management should be considered in the treatment of RCC.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of percutaneous radiofrequency ablation for small renal cancer

et al. 2017

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Abstract. Partial nephrectomy is the treatment of choice for small renal cell carcinoma (RCC) from the perspective of cancer management and renal function. However, when patients with RCC are of advanced age, exhibit severe comorbidities, including cardiovascular and pulmonary diseases, or have hereditary RCC, ablative therapies, including radiofrequency ablation (RFA) and cryoablation are useful treatment options. In the present study, the clinical outcomes of percutaneous RFA for treating small RCC were evaluated. Between December 2005 and March 2015, 40 patients (41 renal tumors in total) underwent RFA and a total of 50 sessions of RFA were performed. The average tumor size was 2.5 cm. A total of 18 tumors were exophytic and 23 were parenchymal. Of the 41 tumors, 85.4% were completely ablated by initial RFA and the rate of complete ablation following reablation for residual viable lesions was 95.1%. Local recurrence-free survival following complete ablation was 84.2% at 3 years. A patient with a 4.7 cm RCC tumor rapidly progressed following four RFA treatments until complete ablation was achieved. The metastasis-free survival rate following initial RFA was 95.7% at 3 years. The RCC-specific survival was 100% (mean follow-up, 38 months). Adverse events occurred in five sessions (10%); however, only 1 patient with arteriovenous fistula required intervention (transarterial embolization). The mean hospital stay following RFA was 3.2 days. The mean decrease in estimated glomerular filtration rate following RFA was 2.7%. The results of the present study indicate that percutaneous RFA was an effective treatment for small RCCs with respect to management of cancer, minimal invasiveness and minimal loss of renal function, particularly in patients for whom surgery would be a high risk and those at increased risk of deterioration of renal function.

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“…In this study, hypertension was an independent predictor of CKD upstage. Suer et al (25) studied the longterm impact of hypertension and diabetes mellitus on GFR in the long term in 488 patients submitted to nephrectomy and noted that hypertension was associated with new onset of chronic renal failure only in the radical nephrectomy group (HR 1.39, 95% CI 1.02 -1.89).…”

Section: Discussionmentioning

confidence: 99%

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

et al. 2012

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ARTICLE INFO _________________________________________________________ ___________________Introduction: While some studies show that patients submitted to radical nephrectomy have a higher risk of developing chronic kidney disease (CKD), some studies report that carefully selected living kidney donors do not present a higher risk for CKD. Here, we aim to study predictive factors of CKD after radical nephrectomy. Materials and Methods: Between January 2006 to January 2010, 107 patients submitted to radical nephrectomy for cortical renal tumors at our institution were enrolled in this study. Demographic data were recorded, modified Charlson-Romano Index was calculated, and creatinine clearance was estimated using abbreviated Modification of Diet in Renal Disease (MDRD) study equation. Pathological characteristics, surgical access and surgical complications were also reviewed. The end-point of the current study was new onset estimated glomerular filtration rate (eGFR) less than 60 and less than 45 mL/minute/1.73 m 2 . Results: Age, preoperative eGFR, Charlson-Romano Index and hypertension were predictive factors of renal function loss, when the end-point considered was eGFR lower than 60 mL/minute/1.73 m

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Comparison of radical and partial nephrectomy in terms of renal function: A retrospective cohort study

Cited by 27 publications

References 15 publications

Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma

Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma

Clinical outcomes of percutaneous radiofrequency ablation for small renal cancer

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

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