Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma

Abstract

Objective: To investigate the time-dependent changes of estimated glomerular filtration rate (eGFR) after radical nephrectomy (RN) and partial nephrectomy (PN) for renal cell carcinoma (RCC) and to determine the risk factors for the new onset of a postoperative eGFR <60 ml/min/1.73 m². Patients and Methods: We assessed the renal function of 253 RCC patients by using the eGFR, and investigated the time-dependent changes of the eGFR after the operation. Regression models were used to determine risk factors for the new onset of an eGFR of <60 ml/min/1.73 m² in 211 patients who had at least one month of postoperative follow-up. Results: From the first postoperative day to the 60th postoperative month the eGFR in the RN group was significantly lower than that in the PN group. For patients who had at least 1 month of postoperative follow-up, multivariable analysis revealed that RN (p < 0.001), age (p = 0.028), and maleness (p = 0.013) were risk factors for the postoperative onset of an eGFR <60 ml/min/1.73 m². Conclusions: Renal function after PN was better than that after RN, and RN was a greater risk factor for the postoperative onset of an eGFR <60 ml/min/ 1.73 m².

Evaluation of the RENAL Nephrometry Scoring System in Adopting Nephron-Sparing Surgery for cT1 Renal Cancer

“…In our study, renal function after NSS was better than that after RN, which was in accordance with the previous report [16]. Among the patients treated by NSS, post-surgical renal function was not significantly associated with the RENAL nephrometry score, although this may be due to insufficient patient numbers.…”

Prediction of partial nephrectomy outcomes by using the diameter‐axis‐polar nephrometry score

“…The number of patients with small and asymptomatic renal tumors has increased in recent years as a result of improvements in radiodiagnosis and the diversity of imaging modalities. Partial nephrectomy has become the standard treatment for small renal tumors with equivalent oncological outcomes, 1,2 better preservation of renal function 3,4 and improved overall survival compared with those of radical nephrectomy. 1,5,6 The feasibility of partial nephrectomy depends on the anatomical characteristics of the tumor.…”

De novo Renal Cell Carcinoma in a Kidney Allograft with Focus on Contrast-Enhanced Ultrasound

“…In every case with suspicion of de novo carcinoma in the transplanted kidney, the tumor must be treated accordingly, mostly by surgery (transplantectomy or partial nephrectomy with or without hilar clamping) [5], preferring NSS whenever possible (based on better postoperative renal function) [18,19]. Comparing the oncological and functional outcome of hilar clamping versus nonhilar clamping partial nephrectomy for RCC in solitary functional kidneys, no differences in intraoperative complications and local recurrence rates between the two groups could be confirmed.…”