Comparison of Rabies Cases Received by the Shomal Pasteur Institute in Northern Iran: A 2-Year Study

Kavoosian, Saeid; Behzadi, Ramezan; Asouri, Mohsen; Ahmadi, Ali Asghar; Nasirikenari, Mehrab; Salehi, Alireza

doi:10.1155/2023/3492601

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…Adult female albino Wistar rats (approximately 8–10 weeks old, 200–250 g) [ 22 , 23 ] were purchased from the Pasteur Institute of Iran, North Research Center (Amol, Iran) [ 24 ]. Rats were kept in an insulated room with a 12-h light/dark cycle at an ambient temperature of 22 ± 3°C and relative humidity of 52 ± 5% and were fed adequately and appropriately [ 25 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Hejazian

Hosseini

Taravati

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer’s model of Wister rats. Rats were divided randomly into seven groups (n = 10). Control group received no treatment, sham group received distilled water orally, aluminum group (AL) was administered AlCl3 (100 mg/kg) orally, extract 1 and 2 groups were treated with only aqueous R. damascena extract (DRE) (500 and 1000 mg/kg), and treatment 1 and 2 groups received aqueous R. damascena extract (500 and 1000 mg/kg) and AlCl3 (100 mg/kg) orally. The brain tissues were sampled for histopathological examination, and biochemical analysis was conducted for estimating the enzyme activities of acetylcholinesterase and catalase (CAT), the levels of GSH and MDA, and ferric reducing antioxidant power. According to the results of behavioral tests, AL administration showed a reduction in spatial memory and remarkably increased the time needed for reaching the invisible platform. The administration of Al-induced oxidative stress and an increase of the enzyme activity of AChE. Al administration increased AChE level from 1.176 ± 0.173 to 3.62 ± 0.348, which was a significant rise. However, treating with the extract at the dose of 1000 mg/kg downregulated it to 1.56 ± 0.303. Administration of the R. damascene extract caused an increased level of catalase and glutathione levels in treatment groups, attenuated MDA level, and regulated AChE activity. Our results illustrate that administration of R. damascene extract has a protective effect against the oxidative damage induced by AlCl3 intoxication in Alzheimer’s model.

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Section: Methodsmentioning

confidence: 99%

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Hejazian

Hosseini

Taravati

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Te natural antioxidants of geraniol, quercetin, and citronellol were purchased from Sigma-Aldrich. Te Hela cells were purchased from the North Research Center of the Pasteur Institute of Iran [24].…”

Section: Natural Antioxidants and Helamentioning

confidence: 99%

Potential of Natural Antioxidants for Upregulating Apoptosis in Cervical Cancer Cells: A Cellular and Molecular Study

Salehi,

Faraji,

Shafaei

et al. 2023

Journal of Chemistry

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Natural antioxidants (NAs) are promising substances, which are established as potent therapeutic agents. However, the anticancer potential of many of them is not completely known. In this research, the anticancer effect of three natural antioxidants including geraniol (Ge), citronellol (Cit), and quercetin (Qu), and their combination by estimating their cytotoxicity on the Hela cells at doses from 15.625 to 1000 µg/mL was investigated. Moreover, cisplatin (Cis) was employed as a strong competitive comparison. After estimating the IC50 value of each treatment in the MTT assay, western blot was performed with the obtained doses for further evaluation. In this regard, the expressions of caspase3, Bax, Bcl2, and p53 proteins were examined. Our results showed that the combination of these natural substances had significant cytotoxic potential by upregulating all mentioned proteins, which demonstrated the apoptosis pathway. Our findings had also the same results in both Cis-receiving and non-Cis-receiving cells regarding some indices. Consequently, it was suggested to further investigate these natural antioxidants as both main or adjuvant therapies for their anticancer potential and side-effect reduction in vivo. Overall, it can be concluded that these natural antioxidants are effective against cancer cells by upregulating the apoptosis pathway.

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“…The infection can only be prevented, not treated, in cases of rabies, which are frequently fatal ( Amoako et al , 2021 ). The primary source of transmission for this disease, which primarily affects underdeveloped nations, is the bite of an animal with rabies, but in industrialized nations, the infection is brought on by the bite of a variety of wild animal species ( Kavoosian et al , 2023 ). Dogs, monkeys, cats, wolves, goats, rabbits, horses, and cows are among the species that are categorized as being at risk of contracting rabies ( Rahman et al , 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Rabies can be found in 150 countries and all continents except Antarctica ( Kavoosian et al , 2023 ). In numerous regions of Asia and Africa, stray dogs are a major cause of human infection ( Knobel et al , 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Tracking lethal threat: In-depth review of rabies

Khairullah,

Kurniawan,

Hasib

et al. 2023

Open Vet J

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An infectious disease known as rabies (family Rhabdoviridae, genus Lyssavirus) causes severe damage to mammals’ central nervous systems (CNS). This illness has been around for a very long time. The majority of human cases of rabies take place in underdeveloped regions of Africa and Asia. Following viral transmission, the Rhabdovirus enters the peripheral nervous system and proceeds to the CNS, where it targets the encephalon and produces encephalomyelitis. Postbite prophylaxis requires laboratory confirmation of rabies in both people and animals. All warm-blooded animals can transmit the Lyssavirus infection, while the virus can also develop in the cells of cold-blooded animals. In the 21st century, more than 3 billion people are in danger of contracting the rabies virus in more than 100 different nations, resulting in an annual death toll of 50,000–59,000. There are three important elements in handling rabies disease in post exposure prophylaxis (PEP), namely wound care, administration of anti-rabies serum, and anti-rabies vaccine. Social costs include death, lost productivity as a result of early death, illness as a result of vaccination side effects, and the psychological toll that exposure to these deadly diseases has on people. Humans are most frequently exposed to canine rabies, especially youngsters and the poor, and there are few resources available to treat or prevent exposure, making prevention of human rabies challenging.

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Comparison of Rabies Cases Received by the Shomal Pasteur Institute in Northern Iran: A 2-Year Study

Cited by 4 publications

References 41 publications

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Effect of Rosa damascena Extract on Rat Model Alzheimer’s Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study

Potential of Natural Antioxidants for Upregulating Apoptosis in Cervical Cancer Cells: A Cellular and Molecular Study

Tracking lethal threat: In-depth review of rabies

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