Comparison of QCT-derived and DXA-derived areal bone mineral density and T scores

Abstract

This study shows that results from QCT aBMD appropriately adjusted can be evaluated against NHANES reference data to diagnose osteoporosis.

Proximally Versus Fully Porous-coated Femoral Stems: A Multicenter Randomized Trial

“…Unfortunately, therefore, DEXA scans cannot be used as a practical routine postoperative evaluative tool. Third, while the majority of DEXA scans were performed at one center with one type of DEXA scanner (Hologic TM QDR4500), the second site employed a different type of scanner (GE Lunar Prodigy), which can introduce a potential evaluation error [21,23]. However, we evaluated changes in bone density from baseline and each patient served as his/her own control in this study design.…”

Application of quantitative computed tomography for assessment of trabecular bone mineral density, microarchitecture and mechanical property

“…Nonetheless, the standard of osteoporosis based on T score by DXA was used in most QCT studies [19][20][21][22]. The American College of Radiology (ACR) has published guidelines for the performance of QCT in lumbar spine in 2008 and amended in 2014.…”

“…The QCT X-Ray Absorptiometry (CTXA) analysis at the hip using pelvis CT images with a calibration phantom and software system was developed by Cann et al (Mindways Software, Inc, Austin, TX) [13,20]. This technique uses a two-dimensional projection (anterior-posterior) of CT three-dimensional formation with software to calculate the area bone density (mg/cm 2 ) in hip and femoral neck integral bone, just like the DXA method.…”

“…This technique uses a two-dimensional projection (anterior-posterior) of CT three-dimensional formation with software to calculate the area bone density (mg/cm 2 ) in hip and femoral neck integral bone, just like the DXA method. When using the CTXA method, T scores should be calculated by conversion equations using the Hologic DXA-acquired NHANES III young normal data [20,74]. The hip CTXA are difficult to use routinely for the assessment of fracture risk due to it's high radiation dose and limitation of two-dimensional assessment.…”

“…The hip CTXA are difficult to use routinely for the assessment of fracture risk due to it's high radiation dose and limitation of two-dimensional assessment. It can be used in cases with a restricted DXA availability or as an additional measure in cases already obtaining a pelvic CT study [13,20,75].…”