Comparison of Propofol with Enflurane Anesthesia in Laparoscopic Cholecystectomy for the Change of Liver Function

Oh, Soo Won; Koo, Gill Hoi; Kim, Sok Ju; Woo, Young Cheol

doi:10.4097/kjae.1999.36.2.279

Cited by 5 publications

(3 citation statements)

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“…Their findings agree with the results of the present study. Similarly, studies performed by Yoon et al [6] and Oh et al [9] on laparoscopic cholecystectomy patients also agreed with our results, in that they found no differences in liver function after surgery with either inhalational anesthesia or anesthesia with propofol. However, their findings differ from those of the present study because postoperative AST and ALT increased beyond the normal range, perhaps because laparoscopic cholecystectomies are associated with relatively greater risk of liver damage due to traction and the surgery itself, more than lumbar discectomies and thyroidectomies.…”

Section: Discussionsupporting

confidence: 93%

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and remifentanil and total intravenous anesthesia with propofol and remifentanil for thyroidectomy

Kim

et al. 2013

Korean J Anesthesiol

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BackgroundInhalation anesthetics are an important factor for postoperative hepatic and renal dysfunction. In this regard, TIVA can reduce the risk of hepatic and renal dysfunction inherited to inhalation anesthetics. The present study was conducted to determine whether hepatic and renal functions differ after anesthesia with sevoflurane and propofol.MethodsTwo hundred patients, ASA physical status class I, II, scheduled for an elective thyroidectomy were randomly divided into two groups. Anesthesia was maintained with sevoflurane 1-2% and remifentanil in the sevoflurane group (Group S) and propofol 2-5 ug/ml and remifentanil 2-5 ng/ml at the effect site, using a target controlled infusion (TCI) pump in the TIVA group (Group T) to maintain BIS of 40-60. To evaluate the hepatic and renal function, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine were tested at preoperation (baseline), postoperative 1 day and 3 days.ResultsAST was increased at postoperative 1 day and 3 days, compared with that of the preoperation in Group S, and postoperative 1 day in Group T, but the values were within its normal limit. ALT was not changed after anesthesia in both groups. BUN was increased at postoperative 1 day, compared with that of the preoperation in Group S, but the value was within its normal limit. Creatinine was not changed after anesthesia in both groups.ConclusionsThe changes of hepatic and renal function after inhalation anesthesia with sevoflurane and TIVA with propofol and remifentanil for thyroidectomy were clinically insignificant, and there was no difference between the two methods.

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Section: Discussionsupporting

confidence: 93%

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and remifentanil and total intravenous anesthesia with propofol and remifentanil for thyroidectomy

Kim

et al. 2013

Korean J Anesthesiol

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“…Furthermore, in the study of Mazze et al, propofol administration was not associated with serum creatinine and BUN abnormalities after surgery [18]. Contrary to our findings, significant increase in AST and ALT occurred after propofol anesthesia following laparoscopic cholecystectomy [19]. Also, severe liver dysfunction has been reported following a short-term propofol anesthesia [20].…”

Section: Discussioncontrasting

confidence: 94%

Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Parsa¹

2018

Austin J Anesthesia and Analgesia

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Introduction: Compared with volatile anesthetics, less information is available about the hepatic and renal impact of intravenous anesthetics. The aim of the present study was to evaluate and compare the effect of midazolam and propofol on postoperative liver and renal functions.Materials and Methods: 58 patients of American Society of Anesthesiologists physical status I and II were randomly divided into two groups of 29 to receive eitherpropofol or midazolam for maintenance of anesthesia. To evaluate hepatic and renal function, preoperative serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, g-glutamyltransferase, creatinine and blood urea nitrogen were compared with those on postoperative days 1 and 3 among two groups. Results and Discussion: There were significant differences between the two anesthetic groups in the level of aspartate aminotransferase and total bilirubin on postoperative day 1, and alanine aminotransferase on postoperative day 3. However, the all values were in the normal range. Conclusion:total intravenous anesthesia with propofol and midazolam had a comparable minor effect on liver and kidney function after surgery.

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“…Contrary to our findings, significant increase in AST and ALT occurred after propofol anesthesia following laparoscopic cholecystectomy [19]. Also, severe liver dysfunction has been reported following a short-term propofol anesthesia [20].…”

Section: Discussioncontrasting

confidence: 56%

Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Parsa¹

2018

Austin J Anesthesia and Analgesia

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Comparison of Propofol with Enflurane Anesthesia in Laparoscopic Cholecystectomy for the Change of Liver Function

Cited by 5 publications

References 0 publications

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and remifentanil and total intravenous anesthesia with propofol and remifentanil for thyroidectomy

Comparison of hepatic and renal function between inhalation anesthesia with sevoflurane and remifentanil and total intravenous anesthesia with propofol and remifentanil for thyroidectomy

Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

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