Postoperative Liver and Kidney Function Following Total Intravenous Anesthesia: A Randomized Controlled Trial

Abstract

Introduction: Compared with volatile anesthetics, less information is available about the hepatic and renal impact of intravenous anesthetics. The aim of the present study was to evaluate and compare the effect of midazolam and propofol on postoperative liver and renal functions.Materials and Methods: 58 patients of American Society of Anesthesiologists physical status I and II were randomly divided into two groups of 29 to receive eitherpropofol or midazolam for maintenance of anesthesia. To evaluate hepatic and renal function, preoperative serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, total bilirubin, g-glutamyltransferase, creatinine and blood urea nitrogen were compared with those on postoperative days 1 and 3 among two groups. Results and Discussion: There were significant differences between the two anesthetic groups in the level of aspartate aminotransferase and total bilirubin on postoperative day 1, and alanine aminotransferase on postoperative day 3. However, the all values were in the normal range. Conclusion:total intravenous anesthesia with propofol and midazolam had a comparable minor effect on liver and kidney function after surgery.