Comparison of propofol‐fentanyl with propofol‐fentanyl‐ketamine combination in pediatric patients undergoing interventional radiology procedures

Erden, İsmail; Pamuk, Almıla Gülsün; Akıncı, Seda Banu; Köseoğlu, Ayhan; Aypar, Ülkü

doi:10.1111/j.1460-9592.2009.02971.x

Cited by 50 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of apnoea was significantly high in patients who received fentanyl as premedicant. Our results were comparable to other studies,[6–9] where fentanyl was used for propofol anesthesia. The awakening time, that is, the time taken when patient opened eyes on verbal commands, was longer in group I.…”

Section: Discussionsupporting

confidence: 91%

Comparison of ketamine with fentanyl as co-induction in propofol anesthesia for short surgical procedures

Goyal

Singh

Sharma

2012

Int J Crit Illn Inj Sci

View full text Add to dashboard Cite

Background and Objective:A prospective randomized control study was conducted to compare and evaluate quality of anesthesia with ketamine or fentanyl as co-induction with propofol.Materials and Methods:Sixty ASA I or II, 18–50 year old patients who were scheduled for minor surgeries of short duration (<30 min anticipated duration) were selected. The patients were randomly allocated to group I and group II comprising 30 patients each. The patients of group I were given ketamine injection 0.5 mg/kg and group II patients fentanyl injection (1.5 μg/kg) as co-induction agent. Two minutes later, induction of anesthesia was given with inj propofol (2.5 mg/kg) and appropriate-sized laryngeal mask airway was inserted. The anesthesia was maintained with 60% N2O in O2 and intermittent bolus of inj propofol (0.5 mg/kg) after observing significant changes in the heart rate, blood pressure, lacrimation, sweating, and abnormal movements.Results:There was significant decrease (P<0.05) in the pulse rate, systolic and diastolic blood pressure at 1, 3, and 5 min in group II (fentanyl group) whereas the change was insignificant (P>0.05) at 10 min.Conclusion:It was observed that ketamine as premedicant was better than fentanyl with respect to hemodynamic stability and caused less adverse effects intraoperatively and postoperatively.

show abstract

Section: Discussionsupporting

confidence: 91%

Comparison of ketamine with fentanyl as co-induction in propofol anesthesia for short surgical procedures

Goyal

Singh

Sharma

2012

Int J Crit Illn Inj Sci

View full text Add to dashboard Cite

show abstract

“…Likewise, in a study by Erden et al 30 propofol-fentanil and propofol-fentanil-ketamine combinations provided similar hemodynamic stability in children. However, in our study hemodynamic stability was not maintained because we used a higher dose of propofol than was used in the previous study.…”

Section: Discussionmentioning

confidence: 82%

Comparison of Propofol and Ketamine-Propofol Mixture (Ketofol) on Laryngeal Tube-Suction II Conditions and Hemodynamics: A Randomized, Prospective, Double-Blind Trial

Özgül

Begeç

Karahan

et al. 2013

Current Therapeutic Research

View full text Add to dashboard Cite

ObjectiveThe aim of our study is to compare the effect of ketamine–propofol mixture (ketofol) and propofol on the laryngeal tube-Suction II (LTS II) insertion conditions and hemodynamics.MethodsEighty American Society of Anesthesiologists class 1 and 2 patients were divided into 2 random groups to receive either 1 µg/kg remifentanil and propofol 2 mg/kg in Group P (n = 40), or 1 µg/kg remifentanil and ketofol (using a 1:1 single syringe mixture of 5 mg/mL ketamine and 5 mg/mL propofol) in Group K (n = 40) before induction of anesthesia. After induction, LTS II was inserted. Heart rate and noninvasive blood pressure were recorded before induction of anesthesia (t0); immediately following induction (t1); immediately after LTS II insertion (t2); and 3 minutes (t3), 5 minutes (t4), and 10 (t5) minutes after LTS II insertion. Conditions of insertion of LTS II were assessed and scored 1 to 3 using 6 variables as follows: mouth opening, swallowing, coughing, head and body movements, laryngospasm, and ease of LTS II insertion by the same experienced anesthesiologist who did not know the agents. LTS II insertion summed score was prepared depending upon these variables.ResultsIn regard to LTS II insertion summed score, Group K was more favorable than Group P (P < 0.05). Apnea duration was longer in Group P (385.0 seconds [range = 195.0–840.0 seconds]) compared with Group K (325.50 seconds [range = 60.0–840.0 seconds]) but this was not statically significant. The heart rate values were significantly lower at all measurement intervals in both groups compared with the baseline values (P < 0.05). There was no difference in heart rate between Group P and Group K. The mean arterial pressure values were significantly lower at all measurement intervals in Group P compared with baseline values (P < 0.05). In Group K, the mean arterial pressure values were significantly lower at all measurement intervals compared with the baseline values, except t2 (P < 0.05). There was a significant difference between Group P and Group K in terms of mean arterial pressure at t3 (P < 0.05).ConclusionsWe found that ketofol provided better insertion summed score for LTS II than propofol, with minimal hemodynamic changes.

show abstract

“…Using ketamine for maintenance sedation has been shown to have favorable hemodynamic and respiratory effects in adult intensive care unit (ICU) patients . The most frequently observed adverse effects associated with ketamine when used for maintenance sedation include arrhythmias (6.7%), hypertension (6%), paradoxical agitation (up to 20%), hypersalivation (12%), and nystagmus (up to 63%) . Although limited literature is available in adults, as many as 57% of pediatric patients who receive ketamine for continuous sedation experience emergence phenomenon, where they experience vivid hallucinations and delirium during or after ketamine use .…”

mentioning

confidence: 99%

Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients

et al. 2017

View full text Add to dashboard Cite

Although the use of ketamine in critically ill mechanically ventilated adult trauma patients was associated with decreased opioid use, it was also associated with increased use of dexmedetomidine and ziprasidone to achieve and maintain sedation. Further examination of clinical outcomes associated with these differences in drug use in a larger population of trauma patients is warranted before routine use of ketamine for analgesia and sedation can be recommended.

show abstract

Comparison of propofol‐fentanyl with propofol‐fentanyl‐ketamine combination in pediatric patients undergoing interventional radiology procedures

Abstract: In conclusion, addition of low dose ketamine to propofol-fentanyl combination decreased the risk of desaturation and it also decreased the need for supplemental propofol dosage in pediatric patients at interventional radiology procedures.

Cited by 50 publications

References 26 publications

Comparison of ketamine with fentanyl as co-induction in propofol anesthesia for short surgical procedures

Comparison of ketamine with fentanyl as co-induction in propofol anesthesia for short surgical procedures

Comparison of Propofol and Ketamine-Propofol Mixture (Ketofol) on Laryngeal Tube-Suction II Conditions and Hemodynamics: A Randomized, Prospective, Double-Blind Trial

Impact of Ketamine Use on Adjunctive Analgesic and Sedative Medications in Critically Ill Trauma Patients

Contact Info

Product

Resources

About