Comparison of propofol and fentanyl anaesthesia in coronary artery versus valve surgery

Bell, J.; Sartain, J.; Wilkinson, G.A.L.; Sherry, K.M.

doi:10.1111/j.1365-2044.1995.tb15122.x

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…When propofol was used as the sole agent for total intravenous anesthesia in humans it proved unsatisfactory for many surgical procedures because the doses required to prevent physical responses to major surgery induced car‐diovascular and respiratory depression 5 . Consequently, when a balanced anesthetic technique was used, propofol was often administered concurrently with short‐acting opioid analgesics such as fentanyl, 6,7 alfentanil, 8,9 or more recently, remifentanil 10 …”

Section: Mean Pharmacokinetic Parameters For Propofol Administered Tomentioning

confidence: 99%

Total Intravenous Anesthesia in Greyhounds: Pharmacokinetics of Propofol and Fentanyl—MA Preliminary Study

Hughes

Nolan

1999

Veterinary Surgery

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Section: Mean Pharmacokinetic Parameters For Propofol Administered Tomentioning

confidence: 99%

Total Intravenous Anesthesia in Greyhounds: Pharmacokinetics of Propofol and Fentanyl—MA Preliminary Study

Hughes

Nolan

1999

Veterinary Surgery

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“…(1) When combined with an opioid like fentanyl, it can provide balanced anaesthesia. (10) There is no evidence of a pharmacokinetic interaction between propofol and fentanyl and their combination provides excellent clinical conditions. (11) Short-acting drugs allow better induction of anaesthesia and may therefore reduce the incidence of respiratory depression and permit rapid recovery which is especially desirable for day care surgery.…”

mentioning

confidence: 99%

A Comparative Evaluation of Two Tiva Techniques for Day Care Surgical Procedures– Midazolam and Ketamine Versus Fentanyl and Propofol

Sharma¹,

Sharma²,

Mohindra³

et al. 2017

jemds

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BACKGROUND TIVA has gained popularity recently partly in order to reduce pollution by volatile agents. The present study was designed to evaluate the comparison of Total intravenous anaesthesia (TIVA) techniques: Midazolam-Ketamine and Propofol-Fentanyl for their cardiovascular effects, intraoperative and postoperative complications and recovery profile. MATERIALS AND METHODSThe study was a non-randomised clinical trial. After approval of the hospital ethical committee, hundred patients from either sex ranging from 20-60 years of age, undergoing short surgical procedures less than an hour of ASA grade I and II were included in this study. The patients were randomly allocated into two Groups of 50 patients each. Group A received injection midazolam 0.05 mg/kg IV and injection glycopyrrolate 0.2 mg IV one minute before injection Ketamine 2 mg/kg IV given over 60 seconds. Thereafter ketamine infusion was started at 50 mcg/kg/min. Group B received injection fentanyl 2 mcg/kg IV. and injection glycopyrrolate 0.2 mg IV one minute before the injection propofol 2.5 mg/kg IV given over 60 seconds. Thereafter, propofol infusion was started at 200 mcg/kg/min. The various parameters studied were induction time, pain on injection, heart rate, respiratory rate, SpO2, recovery time by using Modified Steward Coma Score. RESULTSIn Group A, there was statistically significant rise in heart rate (HR) and mean arterial pressure (MAP) 15 minutes (T15) after induction whereas in Group B there was non-significant fall in HR 25 minutes after induction (T25) but statistically significant fall in MAP at T5. Recovery profile was assessed by Modified Steward Coma Score. In Group A, maximum number of patients i.e. 25 patients have score of 6, 15 minutes after stopping ketamine infusion whereas in Group B 30 patients had score of 6, 5 minutes after stopping propofol infusion. CONCLUSION

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Effects of the propofol combination anesthesia on the intrinsic blood-clotting system

et al. 1999

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Comparison of propofol and fentanyl anaesthesia in coronary artery versus valve surgery

Abstract: Summary Total intravenous anaesthesia with propofol and fentanyl

Cited by 7 publications

References 17 publications

Total Intravenous Anesthesia in Greyhounds: Pharmacokinetics of Propofol and Fentanyl—MA Preliminary Study

Total Intravenous Anesthesia in Greyhounds: Pharmacokinetics of Propofol and Fentanyl—MA Preliminary Study

A Comparative Evaluation of Two Tiva Techniques for Day Care Surgical Procedures– Midazolam and Ketamine Versus Fentanyl and Propofol

Effects of the propofol combination anesthesia on the intrinsic blood-clotting system

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