Comparison of prolonged low volume milk and routine volume milk on incidence of necrotizing enterocolitis in very low birth weight neonates

Armanian, Amir‐Mohammad; Kazemipour, Samira; Mirbod, Sayyedeh-Mahnaz; Hassanzade, Akbar

doi:10.12669/pjms.291(suppl).3523

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…In addition, little evidence exists regarding on what day of life MEN should be initiated. Armanian et al19 found that infants who received 7 days of MEN took longer to reach full feeds than those whose feedings were advanced by 20 mL/kg/d (18.4 days vs 13.4 days; P < .001). Infants receiving MEN experienced fewer episodes of NEC (8.57% vs 25.5%; P = .02) and feeding intolerance—defined as the presence of an undetermined gastric residual volume (26.5% vs 51.1%; P = 0.01).…”

Section: Resultsmentioning

confidence: 99%

Section: Timing Of Feeding Initiation Following Deliverymentioning

confidence: 99%

“…• MEN may prolong the time to attainment of full feeds. 18,19 • Optimal time to initiate feedings within the first 3 d of life.…”

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confidence: 99%

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Feeding Strategies in Preterm Very Low Birth-Weight Infants

Parker

Desorcy-Scherer

Magalhães

2021

Advances in Neonatal Care

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Management of enteral feeding in very low birth-weight ([VLBW] ≤1500 g) infants who are 32 weeks' gestational age or less is extremely challenging for clinicians in the neonatal intensive care unit (NICU). Yet, optimizing nutrition in these vulnerable infants is critical to enhance their growth and prevent prematurityrelated complications. 1 Preterm infants' structurally and functionally immature gastrointestinal (GI) system places them at increased risk for feeding intolerance and necrotizing enterocolitis (NEC), which complicates enteral nutrition decisions. 2 Efforts to reduce the risk of these morbidities often lead to significant variation in feeding strategies among clinicians and hospitals. 3,4 Such

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Section: Resultsmentioning

confidence: 99%

Section: Timing Of Feeding Initiation Following Deliverymentioning

confidence: 99%

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Feeding Strategies in Preterm Very Low Birth-Weight Infants

Parker

Desorcy-Scherer

Magalhães

2021

Advances in Neonatal Care

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“…A total of 2,199 title and abstracts were screened after removing the duplicates, and 102 full texts were retrieved for assessing their eligibility for inclusion. Thirty-nine studies enrolling 6,982 neonates were included in the final synthesis [8, 19‒56] (Table 2). The PRISMA flow is given in online suppl.…”

Section: Resultsmentioning

confidence: 99%

“…While nineteen studies were classified as having a low risk of bias [8,[19][20][21][22][23][24][25]27,28,31,33,36,37,40,41,45,47,48], nineteen studies were categorised as having a variable risk of bias for random sequence generation and allocation concealment. [26,29,30,32,34,35,38,39,[42][43][44]46,[49][50][51][52][53][54][55] None of the RCTs had blinded the intervention to the care providers due to the nature of the intervention. Ten trials had blinded the assessment of NEC.…”

Section: Risk Of Biasmentioning

confidence: 99%

Enteral Feeding Strategies in Preterm Neonates ≤32 weeks Gestational Age: A Systematic Review and Network Meta-Analysis

et al. 2021

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Introduction: Critical aspects of time of feed initiation, advancement, and volume of feed increment in preterm neonates remain largely unanswered. Methods: Medline , Embase, CENTRAL and CINAHL were searched from inception until 25th September 2020. Network meta-analysis with the Bayesian approach was used. Randomized controlled trials (RCTs) evaluating preterm neonates ≤32 weeks were included. Feeding regimens were divided based on the following categories: initiation day: early (<72 h), moderately early (72 h–7 days), and late (>7 days); advancement day: early (<72 h), moderately early (72 h–7 days), and late (>7 days); increment volume: small volume (SV) (<20 mL/kg/day), moderate volume (MoV) (20–< 30 mL/kg/day), and large volume (≥30 mL/kg/day); and full enteral feeding from the first day. Sixteen regimens were evaluated. Combined outcome of necrotizing enterocolitis (NEC) stage ≥ II or mortality before discharge was the primary outcome. Results: A total of 39 studies enrolled around 6,982 neonates. Early initiation (EI) with moderately early or late advancement using MoV increment enteral feeding regimens appeared to be most efficacious in decreasing the risk of NEC or mortality when compared to EI and early advancement with SV increment (risk ratio [95% credible interval]: 0.39 [0.12, 0.95]; 0.34 [0.10, 0.86]) (GRADE–very low). Conclusions: Early initiated, moderately early, or late advanced with MoV increment feeding regimens might be most appropriate in decreasing the risk of NEC stage ≥II or mortality. In view of the certainty of evidence being very low, adequately powered RCTs evaluating these 2 strategies are warranted.

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