Comparison of projections of the dorsal and median raphe nuclei, with some functional considerations

Vertes, Robert P.; Linley, Stephanie B.

doi:10.1016/j.ics.2007.07.046

Cited by 30 publications

(20 citation statements)

References 111 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DR volume of interest used to spatially sort the signal component maps is shown in red hypothesis, we found that the strength of these signal intensity fluctuations was significantly correlated with HA in a number of regions, including the bilateral basal amygdala, ventral hippocampus, insula, and nucleus accumbens, as well as the medial prefrontal cortex. These results are interesting when considering potential roles of the serotonergic system in the expression of HA behaviors, because the networks identified are based not only on activity within and between the DR, but are also consistent with the well-known ascending serotonergic system (Vertes & Linley, 2007).…”

Section: Discussionsupporting

confidence: 62%

“…Recent neuroimaging studies support this hypothesis by suggesting that anxiety is regulated by serotonergic activity and that activity within the ascending serotonergic system plays a crucial role in the pathogenesis of anxiety disorders (Vertes & Linley, 2007;Westlye et al, 2011). Furthermore, high HA has been characterized by high levels of serotonin, which in turns underlies the biology of a highly anxious individual (Montag et al, 2013).…”

Section: Robertmentioning

confidence: 95%

“…We hypothesized that the DR would be functionally connected to regions of the welldescribed ascending serotonergic system, including the hippocampus and amygdala (Vertes & Linley, 2007). Furthermore, we hypothesized that the strength of the functional coupling within some of these regions would be significantly correlated with an individual's HA.…”

Section: Robertmentioning

confidence: 99%

See 2 more Smart Citations

Dorsal raphe nucleus and harm avoidance: A resting-state investigation

Meylakh

Henderson

2016

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

The temperament dimension of harm avoidance defines an individual's biological tendency to exhibit altering levels of anxious, inhibiting, and cautious behavior. High harm avoidance and anxiety are highly comorbid, likely due to activity in similar neural circuitries involving the dorsal raphe nucleus. Despite the many investigations that have explored personality factors and brain function, none have determined the influence of ongoing activity within dorsal raphe networks on harm avoidance. The aim of this study was to explore such a relationship. In 62 healthy subjects, a series of 180 functional magnetic resonance images covering the entire brain were collected, and each subject completed the 240-item TCI-R questionnaire. Independent component analyses were performed to define the dorsal raphe network and then to determine the regions significantly correlated with harm avoidance. The independent component analyses revealed three signal intensity fluctuation maps encompassing the dorsal raphe nucleus, showing interactions with regions of the amygdala, hippocampus, nucleus accumbens, and prefrontal, insular, and cingulate cortices. Within these systems, the resting signal intensity was significantly coupled to harm avoidance in the bilateral basal amygdala, bilateral ventral hippocampus, bilateral insula, bilateral nucleus accumbens, and medial prefrontal cortex. Note that we could not measure serotonergic output, but instead measured signal changes in the dorsal raphe that likely reflect synaptic activity. These data provide evidence that at rest, signal intensity fluctuations within the dorsal raphe networks are related to harm avoidance. Given the strong relationship between harm avoidance and anxiety-like behaviors, it is possible that ongoing activity within this identified neural circuitry can contribute to an individual developing anxiety disorders.

show abstract

Section: Discussionsupporting

confidence: 62%

Section: Robertmentioning

confidence: 95%

Section: Robertmentioning

confidence: 99%

See 1 more Smart Citation

Dorsal raphe nucleus and harm avoidance: A resting-state investigation

Meylakh

Henderson

2016

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

show abstract

“…PAG receives projections from both dorsal raphe nuclei [81] and MNR [82,83] . Anatomically, it consists of distinct, longitudinal functional columns [84] .…”

Section: Discussionmentioning

confidence: 99%

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov¹,

Vonk

Herm

et al. 2011

Neuropsychobiology

View full text Add to dashboard Cite

Background/Aims: Rats display persistent behavioural phenotypes of low (LE) versus high (HE) exploratory activity in the exploration box paradigm. LE rats that prefer passive coping strategies show differential dopaminergic activity in the striatum. The main hypothesis of this study was that chronic variable stress (CVS) would have a higher impact on LE rats. Methods: Animals were submitted to a CVS regimen lasting 32 days that was followed by a behavioural test battery. The functional states of their dopamine D₁ and D₂ receptors were measured in the striatum and nucleus accumbens (NAcc). Cerebral oxidative metabolism was assessed via cytochrome c oxidase histochemistry in 65 brain regions. Results: CVS decreased weight gain, to a higher extent in LE rats, and lowered the sucrose preference after the first week, but habituation to the anhedonic effect had developed by the end of the experiment. CVS did not change the behavioural phenotypes initially assigned. No effect of stress on D₂ receptor function was found. Chronically stressed animals exhibited higher levels of social interaction and D₁ receptor-mediated cAMP accumulation in the NAcc, but not in the striatum. CVS was associated with higher oxidative metabolism levels in the anteroventral thalamus, median raphe nuclei and central periaqueductal grey matter. These changes after stress did not depend upon the exploratory phenotype. Conclusion: This study revealed changes in brain biochemistry after habituation to CVS that might be implicated in successful adaptation to chronic stress.

show abstract

“…The median raphe nucleus (MRN), similar to the dorsal raphe nucleus, is known to be a major source of serotonin (5-hydroxytryptamine; 5-HT) innervation that sends serotonergic efferents predominantly to the hippocampus and, less extensively, to the amygdala (Vertes et al, 1999;Vertes and Linley, 2007), regions that have been implicated in anxiety and fear (Inoue et al, 2011). Moreover, the serotonergic pathway that goes from the MRN has been proposed to play an important role in contextual conditioned fear (i.e., re-exposure to an environment paired previously with inescapable electric footshock), an animal model of anxiety (Andrade et al, 2013).…”

Section: Introductionmentioning

confidence: 99%