Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov, Denis; Vonk, Argo; Herm, Laura; Rinken, Ago; Harro, Jaanus

doi:10.1159/000325224

Cited by 12 publications

(6 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some specific stressors are unpredictable; however, stress itself is not, thus, an adaptive response to chronic variable stress is expected (Matrov et al . 2011). The potential role of the daily exposure to different stressors in the dynamics of body systemic regulation remains to be elucidated, as this hypothesis was beyond the scope of this work.…”

Section: Discussionmentioning

confidence: 99%

Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats

et al. 2021

View full text Add to dashboard Cite

Aim To establish an experimental model combining chronic stress and apical periodontitis by assessing the development of periapical lesions in rats in three different time points. Methodology Forty‐eight male Wistar rats were randomly assigned into two equal groups: Apical periodontitis (AP) and AP + Stress (AP + S). The animals of the AP group were not exposed to stressful conditions whereas the AP + S group were exposed to a variety of stressors on a daily basis until the end of the experiment. After three weeks of chronic unpredictable stress, apical periodontitis was induced in both groups by exposing the pulpal tissue of the mandibular first molar to the oral environment. Each group was further subdivided into three subgroups according to the euthanasia period: 14, 21 and 28 days after pulp exposure. The animals were weighed, and the blood was collected for corticosterone serum dosage by radioimmunoassay. The mandibles were removed and submitted to histopathological and microtomography analyses to assess the inflammatory response and the progression of periapical lesions. Comparisons between the AP and AP + S groups were performed using Student’s t‐test and Mann–Whitney U‐test for parametric and nonparametric data, respectively. The one‐way anova test followed by Tukey’s test (parametric data) and Kruskal–Wallis followed by Dunn’s test (nonparametric data) were used for comparisons between the three time points within the same group (P < 0.05). Results The AP + S group had a significantly lower average percentage of weight gain at 14 days and 21 days after AP induction (P < 0.05). Significantly higher levels of corticosterone were found in the AP + S group at 21 days (P < 0.05). The AP + S group had a significantly greater intensity and extension of inflammatory infiltrate with larger areas of bone loss compared to the AP groups at 21 days (P < 0.05). The volume of the periapical lesions in the AP + S group was significantly larger than that of the AP group 21 days following pulp exposure (P < 0.05). Conclusions The chronic unpredictable stress model applied for 6 weeks exacerbated the inflammatory response and increased bone loss associated with AP, especially 21 days after its induction. This model appears to be suitable for investigating the bidirectional relationship between apical periodontitis and chronic stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Importantly, relationships between D1 mRNA expression and RDT performance were likely not attributable to differences in shock experience in the task. Although there is some evidence that chronic uncontrollable stress can alter D1 receptors (Rasheed et al, 2010; Matrov et al, 2011) it seems unlikely that shock experience in the RDT was experienced as stressful in the same manner, as it was easily avoidable and freely chosen (Maier et al, 2006). Additionally, no relationships were observed between shock experience and several measures of anxiety (Experiment 2), indicating that even high levels of shock experience in the RDT caused no lasting changes in stress- or anxiety-related behavior.…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic Modulation of Risky Decision-Making

Simon¹,

Montgomery²,

Beas³

et al. 2011

J. Neurosci.

150

194

View full text Add to dashboard Cite

Many psychiatric disorders are characterized by abnormal risky decision-making and dysregulated dopamine receptor expression. The current study was designed to determine how different dopamine receptor subtypes modulate risk-taking in young adult rats, using a “Risky Decision-making Task” that involves choices between small “safe” rewards and large “risky” rewards accompanied by adverse consequences. Rats showed considerable, stable individual differences in risk preference in the task, which were not related to multiple measures of reward motivation, anxiety, or pain sensitivity. Systemic activation of D2-like receptors robustly attenuated risk-taking, whereas drugs acting on D1-like receptors had no effect. Systemic amphetamine also reduced risk-taking, an effect which was attenuated by D2-like (but not D1-like) receptor blockade. Dopamine receptor mRNA expression was evaluated in a separate cohort of drug-naive rats characterized in the task. D1 mRNA expression in both nucleus accumbens shell and insular cortex was positively associated with risk-taking, while D2 mRNA expression in orbitofrontal and medial prefrontal cortex predicted risk preference in opposing nonlinear patterns. Additionally, lower levels of D2 mRNA in dorsal striatum were associated with greater risk-taking. These data strongly implicate dopamine signaling in prefrontal corticalstriatal circuitry in modulating decision-making processes involving integration of reward information with risks of adverse consequences.

show abstract

“…As DA turnover in the nucleus accumbens and striatum was found to be affected by stress and/or amphetamine, next we examined the protein levels of D1R and TH, the rate-limiting enzyme in the synthesis of DA. Indeed, previous research by our group (Matrov et al, 2011) had revealed that chronic stress could increase the D 1 receptor-mediated cyclic adenosine monophosphate (cAMP) accumulation in the nucleus accumbens in the rat. However, neither the sucrose preference, nor CVS regimen and repeated amphetamine treatment affected the expression level of the TH and D1R receptor protein levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of chronic variable stress on sensitization to amphetamine in high and low sucrose-consuming rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background: Individual vulnerability to stress manifests in the interaction of innate properties and environment. There is a growing interest in the individual variability in vulnerability to stress and how it contributes to the development of psychiatric disorders. Intake of palatable substances is often measured in animal models. We have previously demonstrated that the consumption of sucrose solution is a stable trait in rats. Aims: The present study aimed to compare the sensitivity of rats with high vs low liquid sucrose consumption to chronic variable stress and the stress effect on behavioural sensitization to amphetamine. Methods: Male Wistar rats were subjected to a chronic stress regimen and subsequent repeated treatment with amphetamine (1 mg/kg, intraperitoneally). Fifty-kHz ultrasonic vocalizations, locomotor activity and stereotypies were measured. Results: In no-stress baseline conditions, the behavioural response to acute amphetamine was similar in rats with high vs low sucrose consumption. Prior chronic stress potentiated the effect of amphetamine only in rats with high sucrose consumption. Behavioural sensitization to repeated administration of amphetamine was observed in non-stressed rats with lower sucrose preference, but not in the respective stressed group that had increased monoamine turnover in the nucleus accumbens. In contrast, in rats with high sucrose preference the amphetamine sensitization effect was prevalent in stressed rats, but not in non-stressed animals. Interpretation: Chronic stress can change the psychostimulant effect but this depends on the inherent reward sensitivity of the animal. Trait-wise, sucrose intake reflects vulnerability to chronic stress and may interact with the development of addiction.

show abstract

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Cited by 12 publications

References 186 publications

Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats

Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats

Dopaminergic Modulation of Risky Decision-Making

Effect of chronic variable stress on sensitization to amphetamine in high and low sucrose-consuming rats

Contact Info

Product

Resources

About