2014
DOI: 10.1111/clr.12326
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Comparison of pro‐inflammatory cytokines and bone metabolism mediators around titanium and zirconia dental implant abutments following a minimum of 6 months of clinical function

Abstract: Objectives Dental implant abutments are fundamental prosthetic components within dentistry that require optimal biocompatibility. The primary aim of this cross-sectional study was to preliminarily assess differences in the pro-inflammatory cytokine and bone metabolism mediator protein expression in the peri-implant crevicular fluid adjacent to transmucosal abutments. Material and Methods Abutments were fabricated from either titanium or zirconia in patients previously receiving single-tooth implant therapy. … Show more

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Cited by 42 publications
(32 citation statements)
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“…The molecular findings of GCF around implants, too, showed that both abutments were clinically biocompatible. 20 It should be pointed out that in that study of the cytokines evaluated, similar to that in the present study, the concentrations of IL-1β and IL-6 around titanium implants were significantly higher than those around ceramic abutments. In another study, too, long-term comparison of cytokines in the fluids and GCF around implants showed that the concentrations of IL-6, IL-4, IL-10, tumor necrosis factor-α, and interferon-δ in the GCF around implants and teeth were not significantly different, with no significant changes over time.…”
Section: Discussionsupporting
confidence: 87%
“…The molecular findings of GCF around implants, too, showed that both abutments were clinically biocompatible. 20 It should be pointed out that in that study of the cytokines evaluated, similar to that in the present study, the concentrations of IL-1β and IL-6 around titanium implants were significantly higher than those around ceramic abutments. In another study, too, long-term comparison of cytokines in the fluids and GCF around implants showed that the concentrations of IL-6, IL-4, IL-10, tumor necrosis factor-α, and interferon-δ in the GCF around implants and teeth were not significantly different, with no significant changes over time.…”
Section: Discussionsupporting
confidence: 87%
“…Similarly, long‐term biocompatibility of the implant materials requires further research especially in relation to dental implants. Although some recent work report no difference in how soft tissue response to abutments made in Ti and in Zi, fatigue, wear, and related microleakage may negatively affect tissue integrity and health.…”
Section: Discussionmentioning
confidence: 95%
“…In addition, these abutments are generally placed with closing torque values lower than what manufacturer recommends due to high risk of abutment fracture . Currently, there is very limited data available on possible microleakage problems related to Zi abutments although the clinical biocompatibility, measured through peri‐implant crevicular fluid content following 6 months of loading, was reported as similar to titanium (Ti) abutments . Thus, the purpose of this study was to investigate microleakage through the implant‐abutment interface using the same implant fixture with two different abutments of the same design.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, a recent study showed zirconia abutments presented a smaller microgap . Also, no significant difference was observed between zirconia and titanium abutments in the amount of oral pathological bacteria, pro‐inflammatory cytokine, and bone metabolism mediator profiles …”
mentioning
confidence: 90%