Comparison of pregabalin with gabapentin as preemptive analgesic in lumbar spine surgery

Routray, Sidharth Sraban; Pani, Nibedita; Mishra, Debasis; Nayak, Sunita

doi:10.4103/joacp.joacp_12_17

Cited by 17 publications

(19 citation statements)

References 24 publications

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“…Pregabalin is a gamma-aminobutyric acid structural analog with a better pharmacodynamic and pharmacokinetic profile. Peripheral neuropathic pain, postherpetic neuralgia, partial seizures, and generalized anxiety disorder can all be treated with it (4). Pregabalin binding to the presynaptic alpha-2-delta (α2-δ) subunits of the voltage-activated calcium channels is significant and necessary for analgesic and anti-epileptic activities, affecting neurological pain reduction be explained by its anticonvulsant modes of action (5).…”

Section: Introductionmentioning

confidence: 99%

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Mohammed¹,

Albadrany²

2022

IJVS

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The study aimed to reveal pregabalin's median effective analgesic dose (ED50) and determine the type of analgesic interaction with tramadol, diclofenac, and paracetamol in chicks. The electrical stimulator device was used to detect pain before and after treatment, and through ascending and descending in doses and depending on the up and down method, the median effective analgesic doses were determined for all drugs used in the study, and then the interaction experiment was conducted at a fixed ratio 0.5:0.5 of pregabalin with each of tramadol, diclofenac and paracetamol of their individual ED50 values, the results were subjected to the isobolographic analysis to determine the type of interaction. Results showed that ED50s for pregabalin, tramadol, diclofenac, and paracetamol in chicks were 156.5, 0.82, 5.65, and 10.74 mg/kg, respectively. Concomitant administration of drugs pregabalin: tramadol, pregabalin: diclofenac and pregabalin: paracetamol at a fixed ratio 0.5:0.5 of their individual ED50 values reduced their ED50s to 36.2:0.18, 64.3:2.3 and 64.3:4.3 mg/kg respectively. Isobolographic analysis showed synergistic analgesic effects of both drugs interaction. The calculated interaction indexes were 0.45, 0.81, and 0.81, respectively. We conclude from the outcomes that the analgesic interaction was synergistic between pregabalin and tramadol significantly, while the analgesic interaction of pregabalin with both diclofenac and paracetamol was also synergistic, but to a lesser extent.

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Section: Introductionmentioning

confidence: 99%

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Mohammed¹,

Albadrany²

2022

IJVS

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“…Sidharth S. Routray, Nibedita Pani, Debasis Mishra, and Sunita Nayak compared placebo, gabapentin and pregablin as preemptive analgesic for lumbar spine surgery and found that gabapentin and pregablin, both have better profile for providing longer post-operative analgesia when compared to placebo 13 . So far only one study did not concur with our finding which might be due to the different kind of surgery i.e.…”

Section: Discussionmentioning

confidence: 99%

To compare the efficacy of Gabapentin with Paracetamol for Preemptive Analgesia in children undergoing Tonsillectomy.

Zeb¹,

Butt²,

Ahmad³

et al. 2022

PJMHS

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Aim: To compare the mean time for first rescue analgesia after preemptive gabapentin versus paracetamol for pain control after tonsillectomy in children. Method: This random controlled trial was conducted by Anesthesia team in ENT OT in Jinnah Hospital, Lahore from January 1, 2018 to June 30, 2018. After taking informed consent, 60 patients fulfilling the selection criteria were recruited and after obtaining demographic information, two groups were formed using lottery method Group G and Group P each having 30 patients. Patients were given oral Paracetamol 20 mg/kg and oral Gabapentin 10 mg/kg 120 minutes before induction of anesthesia in Group P and Group G respectively. Post-operatively, patients’ pain was monitored with VAS after every 30 minutes. When VAS exceeded 3, it marked the demand of first post-operative rescue analgesia was given and time was noted. Injection Ketorolac 0.5mg/kg was given as rescue analgesia. Mean time of first rescue analgesia was compared in between 2 groups via SPSS 19 Results: There were no significant differences for variables such as age and BMI in between two groups. The main result of study is that mean time for first rescue analgesia in group G and group P found to be 468.00± 57.14 & 377.00±51.47 minutes respectively. The calculated p-value was P < 0.0001 proving significant difference in duration for first analgesia in between two groups. Conclusion: There is significant difference in mean time for first rescue analgesia after preemptive gabapentin versus paracetamol for pain control after tonsillectomy in children. Keywords: Preemptive Analgesia, Gabapentine, Paracetamol, Post-operative pain control

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“…Pregabalin has better tolerability, is more efficacious, and has a superior safety profile than gabapentin. Routray et al 9 used pregabalin 300 mg as a preemptive analgesic in lumbar spine surgery. In clinical practice, pregabalin can be used in doses ranging from 150 to 300 mg, often in combination with cyclooxygenase (COX)-2 inhibitors or nonsteroidal antiinflammatory drugs (NSAIDs).…”

Section: Gabapentin and Pregabalinmentioning

confidence: 99%

Opioid Alternatives in Spine Surgery: A Narrative Review

Rajan

Devarajan

Krishnaney

et al. 2020

Journal of Neurosurgical Anesthesiology

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Adequate analgesia is known to improve outcomes after spine surgery. Despite recent attention highlighting the negative effects of narcotics and their addiction potential, opioids have been the mainstay of management for providing analgesia following spine surgeries. However, side effects including hyperalgesia, tolerance, and subsequent dependence restrict the generous usage of opioids. Multimodal analgesia regimens acting through different mechanisms offer significant opioid sparing and minimize the side effects of individual drugs. Hence, they are being increasingly incorporated into enhanced recovery protocols. Multimodal analgesia includes drugs such as N-methyl-D-aspartate antagonists, nonsteroidal antiinflammatory drugs and membrane-stabilizing agents, neuraxial opioids, local anesthetic infiltration, and fascial compartment blocks. Analgesia started before the painful stimulus, termed preemptive analgesia, facilitates subsequent pain management. Both nonsteroidal anti-inflammatory drugs and neuraxial analgesia have been conclusively shown to reduce opioid requirements after spine surgery, and there is a resurgence of interest in the use of low-dose ketamine or methadone. Neuraxial narcotics offer enhanced analgesia for a longer duration with lower dosage and side effect profiles compared with systemic opioid administration. Fascial compartment blocks are increasingly used as they provide effective analgesia with fewer adverse effects. In this narrative review, we will discuss multimodality analgesic regimens incorporating opioid-sparing adjuvants to manage pain after spine surgery.

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Comparison of pregabalin with gabapentin as preemptive analgesic in lumbar spine surgery

Cited by 17 publications

References 24 publications

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

To compare the efficacy of Gabapentin with Paracetamol for Preemptive Analgesia in children undergoing Tonsillectomy.

Opioid Alternatives in Spine Surgery: A Narrative Review

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