Comparison of postoperative lymphocytes and interleukins between laparoscopy-assisted and open radical gastrectomy for early gastric cancer

Xia, Xiang; Zhang, Zizhen; Xu, Jia; Zhao, Gang; Yu, Fengrong

doi:10.1177/0300060518800909

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…These results were in consistent with previous studies, which described lower immune response and inflammatory factors after laparoscopy compared with laparotomy. 12,20 Although pre-and postoperative PLRs were not significantly different in the laparoscopy group, PLRs were significantly increased in the laparotomy group at POD1 and again decreased at POD3. Therefore, in comparison with laparoscopy, laparotomy has a significant effect on PLR enhancement after surgery.…”

Section: Discussionmentioning

confidence: 89%

The pre‐ and postoperative neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios: The comparison of laparoscopy and laparotomy in colorectal cancer patients

Hosseini

Maleknejad

Salem

et al. 2021

Asian J Endoscop Surgery

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Introduction:The management of inflammation after colorectal surgery is important to decrease the susceptibility to postoperative complications. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood are known as two important inflammatory markers. In this study we evaluated and compared colorectal laparoscopy and laparotomy based on the PLR and NLR.Methods: Totally, 76 patients were divided into two groups including patients who underwent laparoscopy (45 cases) or laparotomy (31 cases). The PLR and NLR were calculated based on cell blood count analysis of preoperative and postoperative day (POD) one and three in both groups. Statistical analysis was performed using SPSS software version 22. Results:The PLR and NLR have no significant association with age, gender and tumor site (p > 0.05). However, both ratios were significantly increased in laparotomy patients at POD1 compared with the laparoscopy patients (p < 0.05). According to the two by two comparisons, the preoperative and postoperative PLR were significantly different in the laparotomy group (p < 0.05) but not in the laparoscopy group (p > 0.05). However, the preoperative and postoperative NLR were significantly different in both laparoscopy and laparotomy groups (p < 0.05). Conclusion:The NLR and PLR markers indicated that laparoscopy can be a better choice for colorectal surgery due to lower induction of inflammation compared with laparotomy.

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Section: Discussionmentioning

confidence: 89%

The pre‐ and postoperative neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios: The comparison of laparoscopy and laparotomy in colorectal cancer patients

Hosseini

Maleknejad

Salem

et al. 2021

Asian J Endoscop Surgery

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“…[ 3 ] LG, as a feasible surgical method, has become an effective method for the treatment of gastric cancer. Despite the advantages of LG over open surgery in gastric cancer[ 4 5 ] there are some limitations, for example, the natural tremor of the hand, lack of flexibility, the two-dimensional surgical field of vision and decreased sense of touch. [ 6 7 8 ] In addition, LG has a longer learning curve and causes more fatigue for surgeons.…”

Section: Introductionmentioning

confidence: 99%

Pooled analysis of the oncological outcomes in robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer

Lin

Yang

et al. 2021

Journal of Minimal Access Surgery

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Aim: Robotic gastrectomy (RG) is more and more widely used in the treatment of gastric cancer. However, the long-term oncological outcomes of RG have not been well evaluated. The aim of this study was to evaluate the long-term oncological outcomes of RG and laparoscopic gastrectomy (LG) in the treatment of gastric cancer. Materials and Methods: PubMed, China National Knowledge Infrastructure, Cochrane Library and EMBASE electronic databases were searched until August 2019. Eligible studies were analysed for comparison of oncological outcomes between RG and LG in patients with gastric cancer. Results: Eleven retrospective comparative studies, which included 1347 (32.52%) patients in the RG group and 2795 (67.48%) patients in the LG group, were selected for the analysis. Meta-analysis of the 11 included studies showed that there was no statistically significant difference in the OS between the RG and LG groups (hazard ratios [HRs] = 0.97, 95% confidence intervals [CIs] = 0.80–1.19, P = 0.80). Six studies evaluated disease-free survival (DFS), and pooled analysis showed that there was no statistically significant difference in DFS between RG group and LG group (HR = 0.94, 95% CIs = 0.72–1.23, P = 0.65). According to the odds ratio (OR) analysis, there was no significant difference in 3-year OS, 5-year OS, 3-year DFS and 5-year DFS between the RG and LG groups. Nine articles reported the recurrence rate, and the meta-analysis showed that there was no statistically significant difference between the RG and LG groups (OR = 0.88, 95% CIs = 0.69–1.12, P = 0.31). Conclusions: This meta-analysis indicated that the long-term oncological outcomes in the RG group were similar to that in the LG group.

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“…Chemotherapy is a common auxiliary method for patients with gastric cancer after surgery, which can inhibit the subclinical disease in patients to a certain extent, reduce the activity of tumor cells, minimize the chance of tumor cell proliferation after surgery, and reduce the possibility of recurrence. In addition, chemotherapy can also reduce the adhesion of tumor tissue, decrease the clinical tumor stages, and improve the success rate of surgical resection [ 13 – 15 ]. However, chemotherapy will have severe strong gastrointestinal reactions, myelosuppression, alopecia, and other complications, increasing the pain of treatment and seriously affecting the life quality [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy

Wang

Zhao

et al. 2022

Journal of Healthcare Engineering

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Objective. The purpose was to analyze the effect of early enteral nutrition (EEN) support combined with chemotherapy on related complications and immune function in patients after radical gastrectomy. Methods. 80 patients with gastric cancer treated in our hospital from March 2019 to March 2020 were selected as the research objects and divided into the experimental group and control group according to the random number table, with 40 cases in each group. The control group received chemotherapy only after surgery, while the experimental group received EEN on this basis. The total protein (TP), transferrin (TF), albumin (ALB), immune cells, and other indexes were measured in the two groups before and after treatment to analyze the effect of different treatment methods on the complications and immune function of patients after radical gastrectomy. Results. There were no significant differences in gender ratio, average age, average BMI, pathological types, disease staging, and residence between the two groups ( P > 0.05). The exhaust recovery time, total gastric tube drainage, fluid intake time, and hospitalization time in the experimental group were significantly lower than those in the control group ( P < 0.05). There were no significant differences in the TP, TF, and ALB levels between the two groups before treatment ( P > 0.05), and the TP, TF, and ALB levels in the experimental group were significantly higher than those in the control group after treatment ( P < 0.05). The CD4+/CD8+, CD3+, and CD4+ levels in the experimental group after treatment were significantly higher than those in the control group ( P < 0.001). After treatment, the growth hormone levels in both groups significantly increased ( P < 0.001), and the growth hormone level in the experimental group was significantly higher than that in the control group ( P < 0.001). There was no significant difference in the KPS scores between the two groups before treatment ( P > 0.05), and the KPS score in the experimental group was significantly higher than that in the control group after treatment ( P < 0.001). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group ( P < 0.05). Conclusion. EEN combined with chemotherapy is a reliable method to improve the immune function of patients after radical gastrectomy for gastric cancer, which plays an important role in improving the physical state of patients and reducing the incidence of complications. Therefore, its further research will help to establish a better treatment plan for such patients.

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Comparison of postoperative lymphocytes and interleukins between laparoscopy-assisted and open radical gastrectomy for early gastric cancer

Cited by 11 publications

References 23 publications

The pre‐ and postoperative neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios: The comparison of laparoscopy and laparotomy in colorectal cancer patients

The pre‐ and postoperative neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios: The comparison of laparoscopy and laparotomy in colorectal cancer patients

Pooled analysis of the oncological outcomes in robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer

Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy

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