Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy

Wang, Jing; Wang, Lei; Zhao, Min; Zuo, Xiangsheng; Zhu, Weiming; Cui, Keying; Yan, Xu; Liu, Xiaofei

doi:10.1155/2022/1531738

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Consequently, when refeeding, these patients are more prone to electrolyte disturbances and sodium and water retention as the electrolytes are further displaced ( 27 ). In addition, the lack of food and gastrin stimulation of the intestinal mucosa causes a decrease in the secretion of gastric acid, bile, and other digestive juices, resulting in weakened bactericidal capacities of the intestines, as well as a proliferation and displacement of intestinal toxins, causing an intestinal or systemic inflammatory response that affects the digestive and absorption functions of the intestine ( 31 ). These factors are ultimately detrimental to the implementation of EN.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of risk prediction model for refeeding syndrome in neurocritical patients

Zhang

Zhang²,

Chen³

et al. 2023

Front. Nutr.

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BackgroundThe incidence of refeeding syndrome (RFS) in critically ill patients is high, which is detrimental to their prognoses. However, the current status and risk factors for the occurrence of RFS in neurocritical patients remain unclear. Elucidating these aspects may provide a theoretical basis for screening populations at high risk of RFS.MethodsA total of 357 patients from January 2021 to May 2022 in a neurosurgery ICU of a tertiary hospital in China were included using convenience sampling. Patients were divided into RFS and non-RFS groups, based on the occurrence of refeeding-associated hypophosphatemia. Risk factors for RFS were determined using univariate and logistic regression analyses, and a risk prediction model for RFS in neurocritical patients was developed. The Hosmer-Lemeshow test was used to determine the goodness of fit of the model, and the receiver operator characteristic curve was used to examine its discriminant validity.ResultsThe incidence of RFS in neurocritical patients receiving enteral nutrition was 28.57%. Logistic regression analyses showed that history of alcoholism, fasting hours, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, Sequential Organ Failure Assessment (SOFA) scores, low serum albumin, and low baseline serum potassium were risk factors of RFS in neurocritical patients (p < 0.05). The Hosmer-Lemeshow test showed p = 0.616, and the area under the ROC curve was 0.791 (95% confidence interval: 0.745–0.832). The optimal critical value was 0.299, the sensitivity was 74.4%, the specificity was 77.7%, and the Youden index was 0.492.ConclusionThe incidence of RFS in neurocritical patients was high, and the risk factors were diverse. The risk prediction model in this study had good predictive effects and clinical utility, which may provide a reference for assessing and screening for RFS risk in neurocritical patients.

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Section: Discussionmentioning

confidence: 99%

Development and validation of risk prediction model for refeeding syndrome in neurocritical patients

Zhang

Zhang²,

Chen³

et al. 2023

Front. Nutr.

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“…Previously, in a study by Wang et al [ 26 ], early enteral nutritional support was found to improve immune function in patients after radical chemotherapy gastric cancer to reduce the occurrence of postoperative complications. This is largely consistent with our study.…”

Section: Discussionmentioning

confidence: 99%

Examining the impact of early enteral nutritional support on postoperative recovery in patients undergoing surgical treatment for gastrointestinal neoplasms

Chen,

Hong,

et al. 2023

World J Gastrointest Surg

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Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.

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“…Fifteen studies examined oral or enteral nutrition support before or after cancer surgery; the studies varied in the route and contents of nutrition support delivered and the timing of the intervention and comparison groups. Thirteen studies examined oral or enteral nutrition support before or after chemotherapy and/or radiation; however, they also considerably varied in the route and contents of nutrition support delivered, populations, and timing of the intervention and comparison groups ( 72 , 89 , 174 , 179 , 181 , 184 , 186 , 195 , 205 , 208 , 210 , 213 , 218 ). Finally, 4 studies examined TPN across cancer and treatment types ( 173 , 185 , 209 , 211 ).…”

Section: Effect Of Nutrition Interventions On Symptomsmentioning

confidence: 99%

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

Parsons,

Forte,

Abdi

et al. 2023

JNCI Cancer Spectrum

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Background Among adults with cancer, malnutrition is associated with decreased treatment completion, more treatment harms and use of healthcare, and worse short-term survival. To inform the National Institutes of Health Pathways to Prevention (P2P) workshop, Nutrition as Prevention for Improved Cancer Health Outcomes, this systematic review examined the evidence for the effectiveness of providing nutritional interventions before or during cancer therapy to improve outcomes of cancer treatment. Methods We identified randomized controlled trials (RCT) enrolling ≥50 participants published from 2000 through July 2022. We provide a detailed evidence map for included studies and grouped studies by broad intervention and cancer types. We conducted risk of bias and qualitative descriptions of outcomes for intervention and cancer types with a larger volume of literature. Results From 9,798 unique references, 206 RCT from 219 publications met inclusion criteria. Studies primarily focused on non-vitamin/mineral dietary supplements, nutrition support, and route or timing of inpatient nutrition interventions for gastrointestinal or head and neck cancers. Most studies evaluated changes in body weight/composition, adverse events from cancer treatment, length of hospital stay, or quality of life. Few studies were conducted within the U.S. Among intervention and cancer types with a high volume of literature (n = 114), 49% (n = 56) were assessed as high risk of bias. Higher quality studies (low- or medium risk-of-bias) reported mixed results on the effect of nutritional interventions across cancer and treatment-related outcomes. Conclusions Methodological limitations of nutritional intervention studies surrounding cancer treatment impair translation of findings into clinical practice or guidelines.

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Effect of Early Enteral Nutrition Support Combined with Chemotherapy on Related Complications and Immune Function of Patients after Radical Gastrectomy

Cited by 3 publications

References 23 publications

Development and validation of risk prediction model for refeeding syndrome in neurocritical patients

Development and validation of risk prediction model for refeeding syndrome in neurocritical patients

Examining the impact of early enteral nutritional support on postoperative recovery in patients undergoing surgical treatment for gastrointestinal neoplasms

Nutrition as prevention for improved cancer health outcomes: a systematic literature review

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