Comparison of Population data using 3 AMPFLP systems

Skowasch, K.; Schürenkamp, M.; Rand, S.

doi:10.1007/978-3-642-77324-2_20

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…We compared the allele frequency distribution observed in the Emirati population with those obtained in other studies that have been reported in the literature. We used a four-allele system, 27,33 by which APOB 3' HVR alleles are registered into four classes: HVE<35, HVE35, HVE37 and HVE>37 (Table 2). Whenever all four classes of alleles were available, allele frequency distribution differences were assessed by chi-squared tests with 3 degrees of freedom, and we considered that statistical significance was achieved at P<0.05.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the Apolipoprotein B Gene 3' Hypervariable Region Among Nationals of the Abu Dhabi Emirate and Comparisons with Other Populations

Frossard

Lestringant

1999

Ann Saudi Med

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Background: Among all the polymorphic markers available to date, a hypervariable region located in the 3' of the human apolipoprotein B gene has been extensively studied in global populations throughout the world. Patients and Methods: Using a polymerase chain reaction-based assay, we investigated the allele and genotype frequency distributions of the alleles (corresponding to repeats of a 30 base-pair core DNA sequence) of this hypervariable region in a group of 367 unrelated nationals (201 males, 166 females) from the United Arab Emirates. Results: We found 18 different alleles, ranging from 21 to 55 repeats, making up 51 genotypes that occurred in Hardy-Weinberg proportions and were associated with a heterozygosity index of 80.9%. The allele frequency distribution was different from that of other populations in that it was trimodal, with peaks at 31, 37 and 47 repeats, with corresponding relative frequencies of 16.1%, 25.1% and 6.0%. A four-allele model, which allowed comparisons with other reports, revealed distribution differences with all other ethnic groups except South Asians and Serbs. Conclusion: This marker is very informative for the Emirati population, and will be very useful for UAE-specific DNA fingerprinting. It will also be a valuable tool for assessing the role of apolipoprotein B in cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Analysis of the Apolipoprotein B Gene 3' Hypervariable Region Among Nationals of the Abu Dhabi Emirate and Comparisons with Other Populations

Frossard

Lestringant

1999

Ann Saudi Med

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“…The distribution of the D1S80 alleles was determined by AMP-FLP analysis in the Singapore population (784). Population data have been published for three different AMP-FLP systems in a German population (785). Frequency data for D1S80 amplified by PCR and analyzed by AMP-FLP have been reported for the Danish population (786).…”

Section: Forensic Biochemistrymentioning

confidence: 99%

Forensic Science

Brettell¹,

Saferstein²

1995

Anal. Chem.

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“…allele frequencies were compared with those in other stud ies (table 1). For this purpose a four-allele model was used as suggested by Skowasch et al [11]. The allele frequency distributions in populations from Italy (Bologna) and South Asia were found to be the most similar to the Ser bian population.…”

Section: Introductionmentioning

confidence: 99%